Phage therapy is the use of bacteriophages for therapeutic purposes. Bacteriophages are viruses that infect bacteria with high specificity. Phage therapy was introduced in the early 1900s, but nowadays, with the increase of bacterial resistance to antibiotics, phage therapy has proven to be of great importance and a potential alternative to antibiotics, not only in the field of medicine, but also in veterinary science and agriculture. In our lab, we are interested in understanding the underlying cellular and molecular mechanisms of phage therapy inside human cells infected with different pathogens of interest, and we also aim to engineer recombinant bacteriophages with improved properties to be used for future therapy or as rapid diagnostics for bacterial infections. For our research, we use human cell culture and human cell biology methods, microbiology, biochemistry, molecular & synthetic biology and advanced microscopy.
Current group members:
Robert Ramirez Garcia
Sagona lab news
New publication from Sagona lab in collaboration with the University of Loughborough: https://www.mdpi.com/1999-4923/11/9/475
New publication from Sagona lab funded by Newton British Council award: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235909/
New publication from Sagona lab funded by BBSRC Future Leader Fellowship: https://www.nature.com/articles/s41598-020-65867-4
The first PhD student from Sagona lab, Christian Moller-Olsen, defended his PhD thesis successfully! Well done Christian!
New publication from Sagona lab funded by BBSRC Future Leader Fellowship: https://www.mdpi.com/2079-7737/10/6/556/pdf
New review article in collaboration with Dr Aidan Brown from the University of Edinburgh: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490754/pdf/fmicb-12-724767.pdf
New publication in collaboration with Professor Matthew I. Gibson (Chemistry and WMS), University of Warwick: https://pubs.acs.org/doi/10.1021/acs.biomac.1c01187
New publication from the lab in collaboration with Dr Lauren Cowley, University of Bath and Dr Aidan Brown, University of Edinburgh: Transposable Element Insertions into the Escherichia coli Polysialic Acid Gene Cluster Result in Resistance to the K1F Bacteriophage (asm.org)
Gurneet from Sagona lab published her work! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372555/
New publication in collaboration with Professor Matthew I. Gibson (Chemistry and WMS), University of Warwick, press release: https://warwick.ac.uk/newsandevents/pressreleases/?newsItem=8a1785d787473fef01878ff393227309
Josh from Sagona lab published his work! https://pubmed.ncbi.nlm.nih.gov/37318278/
Gurneet defended her PhD thesis successfully! Well done Gurneet!!!