Skip to main content Skip to navigation

Molecular & Cellular Mechanisms of Phage Therapy

Phage therapy is the use of bacteriophages for therapeutic purposes. Bacteriophages are viruses that infect bacteria with high specificity. Phage therapy was introduced in the early 1900s, but nowadays, with the increase of bacterial resistance to antibiotics, phage therapy has proven to be of great importance and a potential alternative to antibiotics, not only in the field of medicine, but also in veterinary science and agriculture. In our lab, we are interested in understanding the underlying cellular and molecular mechanisms of phage therapy inside human cells infected with different pathogens of interest, and we also aim to engineer recombinant bacteriophages with improved properties to be used for future therapy or as rapid diagnostics for bacterial infections. For our research, we use human cell culture and human cell biology methods, microbiology, biochemistry, molecular & synthetic biology and advanced microscopy.

Current group members: 

Antonia Sagona Dr Antonia Sagona, Group Leader Gurneet Dhanoa

Gurneet Dhanoa, PhD student

Michael Michael Tadesse, PhD student  

Shanthini Thamaraiselvan,

Research Fellow

Joshua Williams Joshua Williams, PhD student

Nathan Burton, PhD student

Veselina Uzunova, Research Fellow

Dan White, PhD student

Joseph Wheatley, PhD student

Joseph is based in Engineering and Antonia is his second supervisor

Robert Ramirez Garcia, PhD student

Previous group members:

Bethany Pearce

Chloe Jade Cooper

Katie Brooks

Panos Tsapras

Kathryn Styles

Inbar Kushnir

Ellie Dorsman

Jaimee Kerven

Maria Czajkowska

Christian Møller-Olsen

Ivan Chan

Rares Chiriac

Sahan Liyanagedera

Richard Amaee

Aristotelis Charmpas

Gabrielle Christie

Stanley Ho

Giz Ibanoglu

Helen Jones

Lucy Kelly

Laurence Legon

Lindo Nyathi

Jess Oliver

Yanahan Paramalingam

Toby Ross

Christina Sheers

Martina Smith

Sophie Smith

Agata Stawicka

Jack Taylor

Matthew Wan

Katherine Winfield

Helen Wrigley

Anna Liuzzi

Ying Tang

Alex Moore

Hannah Vernon-Browne

Sagona lab news

Antimicrobial surfaces applications

New publication in Sagona lab, funded by BBSRC Future Leader Fellowship

New publication from Sagona lab in collaboration with the University of Loughborough:

New publication from Sagona lab funded by Newton British Council award:

New publication from Sagona lab funded by BBSRC Future Leader Fellowship:

The first PhD student from Sagona lab, Christian Moller-Olsen, defended his PhD thesis successfully! Well done Christian!

New publication from Sagona lab funded by BBSRC Future Leader Fellowship:

New review article in collaboration with Dr Aidan Brown from the University of Edinburgh:

New publication in collaboration with Professor Matthew I. Gibson (Chemistry and WMS), University of Warwick:

New publication from the lab in collaboration with Dr Lauren Cowley, University of Bath and Dr Aidan Brown, University of Edinburgh: Transposable Element Insertions into the Escherichia coli Polysialic Acid Gene Cluster Result in Resistance to the K1F Bacteriophage (