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Molecular & Cellular Mechanisms of Phage Therapy

Phage therapy is the use of bacteriophages for therapeutic purposes. Bacteriophages are viruses that infect bacteria with high specificity. Phage therapy was introduced in the early 1900s, but nowadays, with the increase of bacterial resistance to antibiotics, phage therapy has proven to be of great importance and a potential alternative to antibiotics, not only in the field of medicine, but also in veterinary science and agriculture. In our lab, we are interested in understanding the underlying cellular and molecular mechanisms of phage therapy inside human cells infected with different pathogens of interest, and we also aim to engineer recombinant bacteriophages with improved properties to be used for future therapy or as rapid diagnostics for bacterial infections. For our research, we use human cell culture and human cell biology methods, microbiology, biochemistry, molecular & synthetic biology and advanced microscopy.

Current group members: 

Antonia Sagona Dr Antonia Sagona, Group Leader  Wheatley

Joseph Wheatley, PhD student with
Antonia Sagona and Vishwesh Kulkarni

Christian Moller-Olsen Christian Moller-Olsen, PhD student  Richard Amaee

Richard Amaee, Visiting Research

Sahan Bandara

Sahan Bandara, PhD student with
Antonia Sagona and Vishwesh Kulkarni

 Lucy Kelly Lucy Kelly, MSc student
 Joshua Williams Joshua Williams, MRes student  Lindo Nyathi Lindo Nyathi, MBio Student
 Jess Oliver Jess Oliver, MBio student  Kathryn Styles

Kathryn Styles, Post-doctoral
Reserch Fellow

 Sophie Smith Sophie Smith, MRes student    

Previous group members:

Stanley Ho
Aristotelis Charmpas
Toby Ross
Agata Stawicka
Helen Jones
Yanahan Paramalingam
Gabrielle Christie
Matthew Wan
Katherine Winfield
Helen Wrigley
Martina Smith

Sagona lab news

Antimicrobial surfaces applications

New publication in Sagona lab, funded by BBSRC Future Leader Fellowship