Biomedical Sciences
Inspired minds, inspired places
The Biomedical Sciences Directorate (BMS) has a vision to build world-class Discovery Science and Translational Medicine programmes in partnership with the University Hospital Coventry & Warwickshire (UHCW); deliver interdisciplinary educational programmes; and transmit new knowledge to the wider world through an exciting public engagement interface.
Home to 42 Principal Investigators, including clinical and non-clinical academics, BMS has several joint appointments with other departments to drive interdisciplinary work.
Leading edge research centres and programmes
Our Principal Investigators lead key University-wide research centres, externally supported research programmes and innovative education initiatives:
Events and seminars
WMS and SLS Microbiology and Infectious Diseases Seminar: Dr Georgia Isom, University of Oxford
BMS Insights -Talks from our Principal Investigators: Electric fields and osmotic gradients in cells and tissues, Dr Amit Singh and Limits of Epigenetic Homeostasis, Professor Sascha Ott
Influenza Update Meeting
Biomedical Sciences News
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion was published in the Journal of Biological Chemistry last week by a team of scientists from the groups of Mohan Balasubramanian (WMS), Masanori Mishima (WMS), Allister Crow (SLS), Falk Schneider (WMS), Abhishek Kumar (Marine Biological Laboratory) and Lijiang Song (Warwick Chemistry), funded by a collaborative Wellcome Trust bioimaging grant.
This work was led by first author Dr Will Smith, who completed his PhD as part of the MRC DTP.
The work presents a new fluorescent protein named StayRose, which is the first red version of the photobleaching-resistant green protein StayGold. These photostable proteins can be tagged to proteins of interest for microscopy and overcome the previous issue of fluorescence loss during prolonged imaging. StayRose contains an unnatural amino acid, 3-aminotyrosine, which underpins its red colour. Tests showed that StayRose maintains the extreme photostability of StayGold. The work presents a StayRose crystal structure, the first of a 3-aminotyrosine-incorporating fluorescent protein, and demonstrates use of StayRose in bacteria and zebrafish embryos.
Read the paper here.Link opens in a new window
Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN-38 in Treatment of Colorectal Cancer Model
Meet our Principal Investigators
Find out more about our PIs and the important work they lead on.
Inspired minds, inspired places
The Biomedical Sciences Directorate (BMS) has a vision to build world-class Discovery Science and Translational Medicine programmes in partnership with the University Hospital Coventry & Warwickshire (UHCW); deliver interdisciplinary educational programmes; and transmit new knowledge to the wider world through an exciting public engagement interface.
Home to 42 Principal Investigators, including clinical and non-clinical academics, BMS has several joint appointments with other departments to drive interdisciplinary work.
Leading edge research centres and programmes
Our Principal Investigators lead key University-wide research centres, externally supported research programmes and innovative education initiatives:
Leading edge research centres and programmes
Our Principal Investigators lead key University-wide research centres, externally supported research programmes and innovative education initiatives:
Events and seminars
WMS and SLS Microbiology and Infectious Diseases Seminar: A single-molecule view on bacterial nucleoid organization, Dr Christoph Spahn, University of Würzburg
WMS and SLS Microbiology and Infectious Diseases Seminar: Dr Georgia Isom, University of Oxford
BMS Insights -Talks from our Principal Investigators: Electric fields and osmotic gradients in cells and tissues, Dr Amit Singh and Limits of Epigenetic Homeostasis, Professor Sascha Ott
Influenza Update Meeting
Biomedical Sciences News
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion was published in the Journal of Biological Chemistry last week by a team of scientists from the groups of Mohan Balasubramanian (WMS), Masanori Mishima (WMS), Allister Crow (SLS), Falk Schneider (WMS), Abhishek Kumar (Marine Biological Laboratory) and Lijiang Song (Warwick Chemistry), funded by a collaborative Wellcome Trust bioimaging grant.
This work was led by first author Dr Will Smith, who completed his PhD as part of the MRC DTP.
The work presents a new fluorescent protein named StayRose, which is the first red version of the photobleaching-resistant green protein StayGold. These photostable proteins can be tagged to proteins of interest for microscopy and overcome the previous issue of fluorescence loss during prolonged imaging. StayRose contains an unnatural amino acid, 3-aminotyrosine, which underpins its red colour. Tests showed that StayRose maintains the extreme photostability of StayGold. The work presents a StayRose crystal structure, the first of a 3-aminotyrosine-incorporating fluorescent protein, and demonstrates use of StayRose in bacteria and zebrafish embryos.
Read the paper here.Link opens in a new window
Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN-38 in Treatment of Colorectal Cancer Model
Meet our Principal Investigators
Find out more about our PIs and the important work they lead on.