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Judith Klein

Technical Summary

Judith Klein-Seetharaman is Professor of Biomedicine and Systems Biology at the University of Warwick Medical School and the Institute for Digital Healthcare in Coventry, UK. Prior, she was tenured Associate Professor at the Department of Structural Biology at the University of Pittsburgh, USA, Professor in Biological Sciences at Royal Holloway University of London, UK, and held adjunct appointments at the Language Technologies Institute in the School of Computer Science at Carnegie Mellon University, USA, and the Research Centre Juelich, Germany, amongst others. She is currently funded by grants from the NIH, industry, and the Human Frontier Science Program. She was the director of the Erasysbio-funded Salmonella Host Interactions Project European Consortium and was the founding co-director of the NSF-funded Center for Biological Language Modeling ( and the Data Integration and Bioinformatics Core Director of the NIH funded Pittsburgh Centre for HIV Protein Interactions ( She obtained her PhD with late Nobel Laureate Har Gobind Khorana at the Massachusetts Institute of Technology in Cambridge, USA on conformational changes and folding in the G protein coupled receptor, rhodopsin. She holds dual undergraduate degrees in Biology and in Chemistry from the University of Cologne, Germany. She has published over 150 papers and has received a number of awards, including the FP7 People Funded Marie Curie International Incoming Fellowship, the Sofya Kovalevskaya Award of the Humboldt Foundation, a Bill and Melinda Gates Foundation Grand Challenges Award, the NSF CAREER Award and the Margaret Oakley Dayhoff Award of the Biophysical Society for her "remarkable work in computational biology embracing the full spectrum of experimental biophysics".

Selected publications:

Planas-Iglesias J, Dwarakanath H, Mohammadyani D, Yanamala N, Kagan VE, Klein-Seetharaman J. (2015) Cardiolipin Interactions with Proteins. Biophys J. 109(6), 1282-94. PMID: 26300339

Qi, Y., Bar-Joseph, Z. and Klein-Seetharaman, J. (2005) Evaluation of different biological data and computational classification methods for use in protein interaction prediction. Proteins - Structure, Function and Bioinformatics 63, 490-500. (pmid: 16450363; NIHMSID: 345578)

Rader AJ, Anderson G, Isin B, Khorana HG, Bahar I, Klein-Seetharaman J. (2004) Identification of core amino acids stabilizing rhodopsin. Proc Natl Acad Sci U S A. 101(19):7246-51. PMID: 15123809

Klein-Seetharaman, J., Oikawa, M., Wirmer, J., Duchardt, E., Ueda, T., Imoto, T., Smith, L.J., Dobson, C. and Schwalbe, H. (2002) Long-Range Interactions within a Nonnative Protein. Science 295, 1719-1722.