Our research programme in Translational and Experimental Medicine integrates laboratory-based biologists, chemists, engineers and clinicians with computer-based mathematicians, statisticians and data analysts to exploit knowledge derived from fundamental discovery science to develop novel or innovative drugs, devices, techniques and treatments and to provide public health advice for improving the clinical outcomes for patients. The work of the unit is particularly focused on reproductive medicine, metabolic disease and on novel cancer therapy and delivery systems.
A new paper from the Saunders lab introduces CellMet, an open-source toolkit that extracts 3D cell shape and topology metrics within dense tissue. Going beyond basic measures like volume and surface area, CellMet reveal detailed morphological features - such as twisting shape - and highlights how cells interact and organise themselves. From organoids to Drosophila embryos, CellMet provides a powerful framework to reveal hidden tissue architecture.