Biomedical Sciences

Pills

Our research programme in Translational and Experimental Medicine integrates laboratory-based biologists, chemists, engineers and clinicians with computer-based mathematicians, statisticians and data analysts to exploit knowledge derived from fundamental discovery science to develop novel or innovative drugs, devices, techniques and treatments and to provide public health advice for improving the clinical outcomes for patients. The work of the unit is particularly focused on reproductive medicine, metabolic disease and on novel cancer therapy and delivery systems.

Principal Investigators

Events and seminars

This calendar's schedule is empty.

Biomedical Sciences News

Mon 10 Jun '24

Structural characterization and inhibition of the interaction between ch-TOG and TACC3

In this paper we describe the structure of the interaction between TACC3 and ch-TOG. A single helix from ch-TOG, normally bound to two hairpins, pops out and binds to the coiled-coil of TACC3. We then isolated Affimers (non-antibody binders) that inhibit this interaction in vitro. Moving into cells, we could express the Affimers to inhibit the ch-TOG–TACC3 interaction and found a new function for these two proteins in stabilizing the pericentriolar material.
Read the paper here.Link opens in a new window

Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor

Tue 28 May '24

Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: the BAMBINI multicentre, open-label, randomised controlled trial

Dr Erin Greaves explains her lab's research into endometriosis and how she hopes her work could help millions of women worldwide.