Our research programme in Translational and Experimental Medicine integrates laboratory-based biologists, chemists, engineers and clinicians with computer-based mathematicians, statisticians and data analysts to exploit knowledge derived from fundamental discovery science to develop novel or innovative drugs, devices, techniques and treatments and to provide public health advice for improving the clinical outcomes for patients. The work of the unit is particularly focused on reproductive medicine, metabolic disease and on novel cancer therapy and delivery systems.
WMS and SLS Microbiology and Infectious Diseases Seminar: Evolution and an essential host factor for influenza virus - ostriches, mice and flu-resistant chickens, Dr Daniel Goldhill, Royal Veterinary College, University of London
BMS Seminar: Microbial Communities through a Computational Framework, Dr Sara Kalvala, Department of Computer Science, University of Warwick
BMS Seminar: Professor Steffen Scholpp FRSB, Living System Institute, Biosciences, University of Exeter
Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy
This work is based on the discovery of diurnal variations impacting cancer therapy. Especially, use of chronomodulated treatment with 5-fluorouracil (5-FU) has gained significance. Studies indicate high inter-individual variability in diurnal variations in dihydropyrimidine dehydrogenase (DPD) activity – a key enzyme for 5-FU metabolism. However, the influence of individual chronotypes on chronomodulated therapy was unclear but is needed to optimize precision dosing of chronomodulated 5‑FU. Lead by the Thorsten Lehr's PKPD group at the University of Saarland, this collaborative paper is taking a treasure trove of patient 5-FU PK data amalgamated with DPD enzyme activity data from health people to establish a novel PKPD model of 5-FU that captures the extent of diurnal variations in DPD activity and can help investigate individualized chronomodulated 5-FU therapy through testing alternative personalized dosing strategies. Read the paper here.
Dr Meera Unnikrishnan awarded over £2 million for research into C. difficile infection
Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function
Dr Erin Greaves explains her lab's research into endometriosis and how she hopes her work could help millions of women worldwide.