Biomedical Sciences
Our research programme in Translational and Experimental Medicine integrates laboratory-based biologists, chemists, engineers and clinicians with computer-based mathematicians, statisticians and data analysts to exploit knowledge derived from fundamental discovery science to develop novel or innovative drugs, devices, techniques and treatments and to provide public health advice for improving the clinical outcomes for patients. The work of the unit is particularly focused on reproductive medicine, metabolic disease and on novel cancer therapy and delivery systems.
Events and seminars
WMS and SLS Microbiology and Infectious Diseases Seminar: Steve Wu and Elliot Vincent, Warwick Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research (SBIDER)
BMS Seminar: Gene Processing using DonorGuide, GeneWeld and MitoFUSX Base Editors, Professor Steve Ekker, Department of Pediatrics, Dell Medical School, University of Texas Austin
WMS and SLS Microbiology and Infectious Diseases Seminar: A single-molecule view on bacterial nucleoid organization, Dr Christoph Spahn, University of Würzburg
Biomedical Sciences News
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion was published in the Journal of Biological Chemistry last week by a team of scientists from the groups of Mohan Balasubramanian (WMS), Masanori Mishima (WMS), Allister Crow (SLS), Falk Schneider (WMS), Abhishek Kumar (Marine Biological Laboratory) and Lijiang Song (Warwick Chemistry), funded by a collaborative Wellcome Trust bioimaging grant.
This work was led by first author Dr Will Smith, who completed his PhD as part of the MRC DTP.
The work presents a new fluorescent protein named StayRose, which is the first red version of the photobleaching-resistant green protein StayGold. These photostable proteins can be tagged to proteins of interest for microscopy and overcome the previous issue of fluorescence loss during prolonged imaging. StayRose contains an unnatural amino acid, 3-aminotyrosine, which underpins its red colour. Tests showed that StayRose maintains the extreme photostability of StayGold. The work presents a StayRose crystal structure, the first of a 3-aminotyrosine-incorporating fluorescent protein, and demonstrates use of StayRose in bacteria and zebrafish embryos.
Read the paper here.Link opens in a new window
Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN-38 in Treatment of Colorectal Cancer Model
New Dual-Action Antimicrobial Polymers with Anti-Inflammatory Properties
Dr Erin Greaves explains her lab's research into endometriosis and how she hopes her work could help millions of women worldwide.