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Introduction

We have expertise in developing and assessing the novel methodology that underpins innovative clinical trials. Our interests include medical and clinical trial ethics, use of qualitative and mixed methods, quantitative methods including clinical trial statistics and development of patient reported outcome measures (PROMs). Our methodological work informs guidelines and we work closely with our colleagues in Warwick Clinical Trials Unit and other institutions to bring novel methodology to practical application. 

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CTU

Clinical Trials Unit

The Warwick Clinical Trials Unit (WCTU) has a strong track record in delivering excellent research. Established in 2005, we received full registration status from the UKCRC in 2007.

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Warwick Primary Care

Warwick Primary Care is engaged in clinical trials. For example, Socwell is a randomised controlled trial which evaluates an internet self-help package for sub-clinical social anxiety and its effect on quality-of-life, mental well-being, depression and general anxiety.

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mhw

Mental Health & Wellbeing

Our Mental Health and Wellbeing academics are involved in clinical trials through the CIRCLE study, which is a randomised controlled trial of the clinical and cost-effectiveness of a psychological intervention incorporating adjunctive contingency management for reduction of cannabis use and of relapse in early psychosis.

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ethics

Warwick Medicine, Ethics and Society

We have a research interest in the ethics of recruitment and consent processes for trials involving participants from vulnerable populations including trials in emergency care and in people with cognitive impairment. Trials that we have recently been involved with include DAPA and PARAMEDIC2.

Understanding how an intervention works, why it does not work and how it is experienced requires a mixed methods design combining data from observation and interviews with data captured as part of the trial and publicly available data. One example is the Chronic Headache Education and Self-management Study (CHESS) to investigate whether a new education and self-management programme will help improve quality of life for people living with chronic headaches.

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clahrc

Collaboration for Leadership in Applied Health Research and Care West Midlands (CLAHRC)

Research teams at CLAHRC West Midlands and W-CAHRD led by Professor Richard Lilford are one of the world’s renowned groups in methodological development and application of stepped wedge cluster randomised trials. Recent and ongoing works include framework for incorporating parallel and multi-level design, the extension of the CONSORT reporting guidelines for stepped wedge cluster randomised trials, and evaluation of the impact of a community health worker programme in Malawi.

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wrn

Warwick Research In Nursing

We bring significant expertise and experience in patient-reported outcomes (PRO) research of relevance to clinical trials including: Core Outcome Set development, and PRO measure (PROM) development, psychometric and qualitative evaluation, reviewing and selection for clinical trials. One of the trials we are involved with include CHESS (psychometric evaluations) and Core Outcome Sets for Headache (COSH), a sub-study of CHESS. Other works include Core Outcome Set for Cardiac Arrest (COSCA) initiative which is a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation.

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he

Centre for Health Economics at Warwick (CHEW)

A core body of our work involves economic evaluations conducted alongside randomised controlled trials coordinated by the Warwick Clinical Trials Unit. Our research involves work on economic aspects of health and disease, economic evaluations of aspects of care, and the design and evaluation of health systems.

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Centre for Health Economics at Warwick (CHEW)

HE

A core body of our work involves economic evaluations conducted alongside randomised controlled trials coordinated by the Warwick Clinical Trials Unit. Our research involves work on economic aspects of health and disease, economic evaluations of aspects of care, and the design and evaluation of health systems.