RNAi Tissue plasticity Cancer Biology Lipid metabolism Diabetes Head of Molecular Medicine @ Warwick and Director of Postgraduate Course in Cardiovascular risk and Organiser of MSc modules in CV risk
Executive Director Silence Therapeutics PLC 2013-present, CMO from 2012-2014, Head of Translational Medicine 2015-present: 3 years of board-level experience in Industry. Head hunted to join this RNAi therapeutics company, initially as an NED and advisor in 2012 and invited to become CMO and Executive Director later that year. Formulated company strategy for R and D, planning and initiating preclinical and translational projects. Managing relationships with CROs and academic collaborators. Active across many thematic areas of drug development from preclinical through regulatory and planning, initiation and running of Clinical Trials. Contributed to three successful fund-raising efforts and took part in all road-shows/funder presentations, raising over £80,000,000 since 2013. Invited speaker at several industry events/conferences. Have been the public face of the company at conferences. Over 30 years of clinical experience, including 17 years as a senior NHS consultant physician and clinical academic, in general medicine, diabetes and endocrinology: Run county coronary prevention and diabetes clinical services. General medical take and in-patient care. Strong track record in service development, research and high-level senior management both in the NHS and University. Have held numerous senior roles at national and international level, including with the EC and NICE. Much of this past expertise and experience is directly relevant to translational research, decision making and strategic planning in industry. Given, the emphasis on partnerships between academia and industry now in drug development, my experience of both sectors at high-level will be very useful. Maintained Clinical and research position at 1 day a week. This was deemed to be advantageous for Silence Therapeutics PLC and was accepted by UHCW and University of Warwick for the same reasons, namely helping to build academic-private sector partnerships. Has facilitated development of new clinical trials in HNSCC, a preclinical programme in preeclampsia and a drug delivery programme for ODN using conjugation chemistry. Other Relevant experience Expert advisor to NICE. Expert advisor and panel member Clinical Guidelines Development Group (CGDG) and NICE for Cardiovascular risk and lipid-lowering drugs 2012-2014. Made a substantial contribution, over 2 years, to developing and writing the new NICE guideline (CG181) on Lipid-lowering drugs and assessment of cardiovascular risk. Overall extended access to statins to over 5 million more adults in England by reducing the risk threshold for intervention from 20% to a 10% predicted risk of CVD over 10 years. Highly cited researcher, over 100 publications across basic science and clinical medicine including in Cell, Nature, BMJ and Lancet. Just under 3000 citations, H-factor 18. Published the second edition of the popular Molecular Biology of Cancer- Willey-Blackwell. Grants and awards, 2 active grants and over 2 million pounds funding from BBSRC and QNRF, looking at pregnancy-associated diabetes and colon cancer biomarkers respectively. Elected to FRCS and Association of Physicians. EC advisor. 2002- present. Senior administrative roles. Head of Molecular Medicine at University of Warwick from 2002-2006 (completed 5 year period). Member of Senior Management group for Department of Biological Sciences, 2002-2006. One of the pioneers of Warwick Systems Biology. Chair of the exam boards for Cardiovascular risk and Cancer biology MSc courses and Postgraduate awards. 2010- 2015: Member of the trust resuscitation committee and am senior member on the local ethics committee. Founder member and board for MLSRF charity (Chair- Sir Paul Nurse). Founder member and advisory board for the Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM). In 2011 and 2014, Organiser, scientific committee member and local host for HEART UK. Grant reviewer and research analyst Extensive experience reviewing large multi-million euro grants for the EC; Marie Curie, ITNs, STREPS, NoEs, IPs, from FP5 through to Horizon 2020. Also for the BBSRC, EPSRC and MRC in the UK. Also grants aimed specifically at private sector funding, including Eurostars. Experience in applying for Innovate UK grants. Acted as advisor on infrastructure funding to the Government of Cyprus on behalf of the EC. Frequent reviewer for scientific journals.
- Young, J., Pelengaris, Stella, Chipperfield, Andrew, Heath, William, Khan, Michael. Engineering beta cell mass regulation in diabetes. Current Topics in Biochemical Research, Vol.10 (No.1), pp. 47-78
- Raza, Shan-e-Ahmed, Cheung, Linda, Shaban, Muhammad, Graham, Simon, Epstein, D. B. A., Pelengaris, Stella, Khan, Michael, Rajpoot, Nasir M., 2019. Micro-Net : a unified model for segmentation of various objects in microscopy images. Medical Image Analysis, 52, pp. 160-173
- Khan, Adnan M., Raza, Shan-e-Ahmed, Khan, Michael, Rajpoot, Nasir M., 2014. Cell phenotyping in multi-tag fluorescent bioimages. Neurocomputing, 134, pp. 254-261
- Kovacheva, Violeta N., Khan, Adnan M., Khan, Michael, Epstein, D. B. A., Rajpoot, Nasir M. (Nasir Mahmood), 2014. DiSWOP : a novel measure for cell-level protein network analysis in localized proteomics image data. Bioinformatics, 30 (3), pp. 420-427
- Khan, Michael, Taibjee, S. M., Poole, C. J., Gach, J. E., 2014. Bullous reaction at docetaxel infusion site. Clinical and Experimental Dermatology, 39 (1), pp. 58-60
- Schultheis, B., Strumberg, D., Santel, A., Vank, C., Gebhardt, F., Keil, O., Lange, C., Giese, K., Kaufmann, J., Khan, Michael, Drevs, J., 2014. First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors. Journal of Clinical Oncology, 32 (36), pp. 4141-4148
- Tarabra, Elena, Pelengaris, Stella, Khan, Michael, 2012. A simple matter of life and death : the trials of postnatal beta-cell mass regulation. International Journal of Endocrinology, Vol.2012
- Kolling, J., Langenkamper, D., Abouna, S., Khan, Michael, Nattkemper, Tim W., 2012. WHIDE--a web tool for visual data mining colocation patterns in multivariate bioimages. Bioinformatics, Vol.28 (No.8), pp. 1143-1150
- Zhou, Luxian, Pelengaris, Stella, Abouna, Sylvie, Young, James, Epstein, D. B. A., Herold, Julia, Nattkemper, Tim W., Nakhai, Hassan, Khan, Michael, 2012. Re-expression of IGF-II is important for beta cell regeneration in adult mice. PLoS ONE, Vol.7 (No.9)
- Raza, Shan-e-Ahmed, Humayun, Ahmad, Abouna, Sylvie, Nattkemper, Tim W., Epstein, D. B. A., Khan, Michael, Rajpoot, Nasir M. (Nasir Mahmood), 2012. RAMTaB : robust alignment of multi-tag bioimages. PLoS One, Vol.7 (No.2)
- Wang, Yi-Fang, Khan, Michael, Berg, Hugo van den, 2012. Interaction of fast and slow dynamics in endocrine control systems with an application to ß-cell dynamics. Mathematical Biosciences, Vol.235 (No.1), pp. 8-18
- Kolling, J., Langenkamper, D., Abouna, Sylvie, Khan, Michael, Nattkemper, T. W., 2012. WHIDE - a web tool for visual data mining colocation patterns in multivariate bioimages. Bioinformatics, 28 (8), pp. 1143-1150
- Kuse, Manohar, Wang, Yi-Fang, Kalasannavar, V, Khan, Michael, Rajpoot, Nasir M. (Nasir Mahmood), 2012. Local isotropic phase symmetry measure for detection of beta cells and lymphocytes. Journal of Pathology Informatics, Vol.2 (No.2)
- Hattersley, John G., Möhlig, Matthias, Roden, Michael, Dr., Arafat, Ayman M., Loeffelholz, Christian von, Nowotny, Peter, Machann, Jürgen, Hierholzer, Johannes, Osterhoff, Martin, Khan, Michael, Pfeiffer, Andreas F. H., Weickert, Martin O., 2012. Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques. PLoS ONE, Vol.7 (No.6)
- Robson, Samuel Charles, Ward, Lesley (Lesley A.), Brown, Helen (Helen E.), Turner, Heather, Hunter, Ewan, Pelengaris, Stella, Khan, Michael, 2011. Deciphering c-MYC-regulated genes in two distinct tissues. BMC Genomics, Vol.12(No.9 (Sept))
- Loyek, Christian, Rajpoot, Nasir M. (Nasir Mahmood), Khan, Michael, Nattkemper, Tim W., 2011. BioIMAX : a web 2.0 approach for easy exploratory and collaborative access to multivariate bioimage data. BMC Bioinformatics, Vol.12 (No.1)
- Bhattacharya, Sayantan, Mathew, George, Ruban, Ernie, Epstein, D. B. A., Krusche, Andreas, Hillert, Reyk, Schubert, Walter, Khan, Michael, 2010. Toponome imaging system in situ protein network mapping in normal and cancerous colon from the same patient reveals more than five-thousand cancer specific protein clusters and their subcellular annotation by using a three symbol code. Journal of Proteome Research, Vol.9 (No.12), pp. 6112-6125
- Cheung, Linda, Zervou, Sevasti I., Mattsson, Göran, Abouna, Sylvie, Zhou, Luxian, Ifandi, Vasiliki, Pelengaris, Stella, Khan, Michael, 2010. c-Myc directly induces both impaired insulin secretion and loss of ß-cell mass, independently of hyperglycemia in vivo. Islets, 2 (1), pp. 37-45
- Abouna, Sylvie, Old, R. W., Pelengaris, Stella, Epstein, D. B. A., Ifandi, Vasiliki, Sweeney, Ian, Khan, Michael, 2010. Non-ß-cell progenitors of ß-cells in pregnant mice. Organogenesis, 6 (2), pp. 125-133
- Zervou, S., Wang, Y. -F., Laiho, A., Gyenesei, A., Kytomaki, L., Hermann, R., Abouna, Sylvie, Epstein, D., Pelengaris, Stella, Khan, Michael, 2010. Short-term hyperglycaemia causes non-reversible changes in arterial gene expression in a fully 'switchable' in vivo mouse model of diabetes. Diabetologia, Vol.53 (No.12), pp. 2676-2687
- Pascal, Severine M. A., Guiot, Yves, Pelengaris, Stella, Khan, Michael, Jonas, Jean-Christophe, 2008. Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets. American Journal of Physiology: Endocrinology and Metabolism, Vol.295 (No.1), pp. E92-E102
- Pelengaris, Stella, Abouna, Sylvie, Cheung, Linda, Ifandi, Vasiliki, Zervou, Sevasti I., Khan, Michael, 2004. Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis. BMC Biology, Vol.2 (No.26)
- Robson, Sam, Pukonen, Inga, Abouna, Sylvie, Pelengaris, Stella, Khan, Michael, 2010. c-Myc and Downstream Targets in the Pathogenesis and Treatment of Cancer. In Frontiers in Anti-Cancer Drug Discovery, Netherlands, Bentham Science Publishers Ltd, pp. 340-379
- Langenkamper, D., Kolling, J., Humayun, A., Abouna, Sylvie, Epstein, D. B. A., Khan, Michael, Rajpoot, Nasir M. (Nasir Mahmood), Nattkemper, Tim W.. Towards Protein Network Analyis using TIS Imaging and Exploratory Data Analysis. 8th International Workshop on Computational Systems Biology, Zürich, Switzerland, June 6-8, 201, Published in Proceeding of the 8th International Workshop on Computational Systems Biology, pp. 109-113
- Humayun, A., Raza, Shan-e-Ahmed, Waddington, C., Abouna, Sylvie, Khan, Michael, Rajpoot, Nasir M. (Nasir Mahmood), 2011. A novel framework for molecular co-expression pattern analysis in multi-channel toponome fluorescence images. MIAAB 2011 (Microscopic Image Analysis with Applications in Biology), Heidelberg, Germany, 2 Sep 2011, Published in Proceedings of the 2011 Microscopic Image Analysis with Applications in Biology
- Langenkämper, Daniel, Kölling, Jan, Abouna, Sylvie, Khan, Michael, Niehaus, Karsten, Nattkemper, Tim W., 2011. TICAL - a web-tool for multivariate image clustering and data topology preserving visualization. MIAAB 2011 (Microscopic Image Analysis with Applications in Biology), Heidelberg, Germany, 2 Sep 2011, Published in Proceedings of the 2011 Microscopic Image Analysis with Applications in Biology, pp. 1-5
- Herold, Julia, Zhou, Luxian, Abouna, Sylvie, Pelengaris, Stella, Epstein, D. B. A., Khan, Michael, Nattkemper, Tim W., 2010. Integrating semantic annotation and information visualization for the analysis of multichannel fluorescence micrographs from pancreatic tissue. 8th IEEE International Conference on Bioinformatics and Bioengineering, Athens, Greece, October 08-10, 2008, Published in Computerized Medical Imaging and Graphics, pp. 446-452
- Abouna, Sylvie, Old, R. W., Pelengaris, Stella, Epstein, D. B. A., Ifandi, V., Sweeney, I., Khan, Michael, 2009. Non beta cell progenitors of beta cells in pregnant mice. 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, Austria, SEP 30-OCT 02, 2009, Published in Diabetologia, pp. S185-S185
- Zhou, Luxian, Pelengaris, Stella, Abouna, Sylvie, Young, J., Epstein, D. B. A., Khan, Michael, 2009. IGF-II reexpression in adult mice is essential for beta cell regeneration in vivo. 45th Annual Meeting of the European Association for the Study of Diabetes, Vienna, Austria, September 30-October 02, 2009, Published in Diabetologia, pp. S23-S23
- Pascal, S. M. A., Pelengaris, Stella, Khan, Michael, Jonas, J. C., 2008. Effets d'une activation contrôlée du facteur de transcription c-MYC sur la fonction et la survie des cellules pancréatiques de souris. Congrès annuel de l'Alfediam Bruxelles, Brussels, Belgium, 25-28 Mar, 2008, Published in Diabetes & Metabolism
- Herold, Julia, Abouna, Sylvie, Zhou, Luxian, Pelengaris, Stella, Epstein, D. B. A., Khan, Michael, Nattkemper, Tim W., 2008. A machine learning based system for multichannel fluorescence analysis in pancreatic tissue bioimages. 8th IEEE International Conference on Bioinformatics and Bioengineering, Athens, Greece, October 08-10, 2008, Published in Proceedings of the 8th IEEE International Conference on Bioinformatics and Bioengineering, pp. 881-886
- Zervou, S., Pelengaris, Stella, Epstein, D., Khan, Michael, 2007. Reversible and irreversible changes in arterial gene expression after initiation of hyperglycaemia in plus -MYCER mice in vivo. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S90-S90
- Pascal, S. M. A., Pelengaris, Stella, Khan, Michael, Jonas, J.-C., 2007. Effects of controlled c-MYC activation on mouse pancreatic beta cell survival and function. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam, Netherlands, Sep 18-21, 2007, Published in Diabetologia, pp. S183-S183
- Bhattacharya, S., Mathew, G., Jayne, D. G., Pelengaris, Stella, Khan, Michael, 2009. 15-Lipoxygenase-1 in colorectal cancer: a review. Tumor Biology, Karger, pp. 185-199
- Robson, Samuel Charles, Pelengaris, Stella, Khan, Michael, 2006. c-Myc and downstream targets in the pathogenesis and treatment of cancer. Recent Patents on Anti-Cancer Drug Discovery, Bentham Science Publishers Ltd, pp. 305-326
Title | Funder | Award start | Award end |
---|---|---|---|
Taiwan Partnering Award for the Analysis of Digitised Images of Immunohistochemically (IHC) Stained Serial Tissue Sections of Mouse Pancreata | BBSRC | 01 May 2016 | 30 Apr 2018 |
Origin of new beta cells during pregnancy using PCLT and TIS microscopy | BBSRC | 01 May 2013 | 31 Oct 2017 |
Novel Biomarkers for early diagnosis and screening of colorectal cancer via computerized analysis of highly muliplexed protein fluorescence inmage data generated by novel toponome imaging system | Qatar National Research Fund | 01 Oct 2012 | 30 Sep 2015 |
Support for Dr M Khan - (Backdated 01/04/2005) | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2005 | 31 Mar 2013 |
Multichannel Microscopy, Applied to 1) Colon Cancer 2) Beta Cell Regeneration | Royal Society | 16 Mar 2011 | 15 Mar 2013 |
The Role of Adipose Tissue in Obesity: Beta Cell Crosstalk (ADIBET). | European Commission | 01 Jun 2008 | 31 May 2012 |
WPH Charitable Trust Foundation via MRF | WPH Charitable Trust | 01 Jan 2010 | 31 Dec 2010 |
Funding to support Sylvie Abouna (3) - five month extension (clinical trials account UHCW - T8922) | University Hospitals Coventry and Warwickshire NHS Trust | 01 May 2010 | 30 Sep 2010 |
Funding to support Sylvie Abouna (2) - one month extension (clinical trials account UHCW-T8922) | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2010 | 30 Apr 2010 |
Funding to Support Sylvie Abouna in Research Group | University Hospitals Coventry and Warwickshire NHS Trust | 01 Sep 2009 | 28 Feb 2010 |
Training Fellowship for Mr Luxian Zhou | Medical Research Fund of Warwick | 01 Oct 2007 | 30 Sep 2009 |
Transgenic modelling of beta-cell homeostasis | EPSRC | 01 Sep 2007 | 31 Aug 2009 |
Proof concept study for use of topical oral cyclo-oxygenase inhibitors (cox-1) mouthwash. | Cancer Research UK | 01 Apr 2007 | 31 Mar 2009 |
Use of unique animal models to study the reversible effects of hyperglycaemia on the arterial endothelium in vivo | Wellcome Trust | 01 Sep 2005 | 31 Aug 2008 |
Prevention of Beta Cell Apoptosis and Dysfunction by Exenatide in Endoenous and Transplanted Islets in Mouse Diabetes Models in Vivo | Eli Lilly and Co Limited | 01 Oct 2005 | 30 Sep 2007 |
Admin Support - Understanding the spread of cancer (metastasis) | WPH Charitable Trust | 01 Oct 2004 | 30 Sep 2007 |
Donation: Support for L Cheung - Cross reference with 11841 | Sir Samuel Scott of Yews Trust | 01 Oct 2004 | 01 Oct 2005 |
Donation: Support for L Cheung - cross ref with 11842 | General Charities (Coventry) | 01 Oct 2004 | 01 Oct 2005 |
Use of animal models to study regeneration of pancreatic islets in the adult | Leverhulme Trust | 01 Dec 2004 | 31 May 2005 |
Funding of Dr Mike Khan - Senior Clinical Lecturer | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2004 | 31 Mar 2005 |
Unrestricted Gift | Pfizer Limited | 01 Apr 2003 | 31 Mar 2004 |