Stefan Roesner

Assistant Professor (Research Focused)

S.Roesner@warwick.ac.uk
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About Me

Stefan Roesner received his Diploma in chemistry from Philipps-University Marburg, Germany in 2010. He moved to the UK and completed a Ph.D. in organic chemistry with Prof. Varinder Aggarwal at the University of Bristol in 2014. After postdoctoral studies at the Massachusetts Institute of Technology under the supervision of Prof. Stephen Buchwald, he returned in 2016 to the UK to become Senior Research Fellow in the Shipman group. In October 2021 he was promoted to become Assistant Professor.

Biography

since 2021, Fellow of the EUTOPIA Young Leaders Academy
since 2021, Assistant Professor, University of Warwick, UK
2016-2021, Senior Research Fellow, University of Warwick, UK
2015-2016, Postdoctoral Research Associate, Massachusetts Institute of Technology, USA
2014, PhD from University of Bristol, UK
2010, Dipl. Chem. from Philipps-University Marburg, Germany

Current Projects Research interests Publications

• M. Nutter, H. Stone, M. Shipman, S. Roesner, Org. Biomol. Chem. 2024, DOI: 10.1039/d4ob00278d. ‘Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics’. [Abstract]

• G. Saunders, S. Spring, E. Jayawant, I. Wilkening, S. Roesner, G. Clarkson, A. Dixon, R. Notman, M. Shipman, Chem. Eur. J. 2024, e202400308. ‘Synthesis and Functionalization of Azetidine-Containing Small Macrocyclic Peptides’. [Abstract]

• R. Mohanrao, C. S. Pinto, A. Suchenko, G. J. Clarkson, M. Wills, S. Roesner, M. Shipman, M. K. Balasubramanian, ChemRxiv 2024, DOI:10.26434/chemrxiv-2024-s1fzw. ‘Single-benzene-based clickable fluorophores for in vitro and in vivo bioimaging’. [Abstract]

• S. Boswood, S. Roesner, Targets Heterocycl. Syst. 2023, 27, 1. ‘Methodologies for the Synthesis of β-Carbolines’. [Abstract]

• J. Kim, X. Ren, Y. Zhang, D. Fazzi, S. Manikandan, J. W. Andreasen, X. Sun, S. Ursel, H.-I. Un, S. Peralta, M. Xiao, J. Town, A. Marathianos, S. Roesner, T.-T. Bui, S. Ludwigs, H. Sirringhaus, S. Wang, Adv. Sci. 2023, 2303837. ‘Efficient N-type Organic Electrochemical Transistors and Field-effect Transistors based on PNDI-Copolymers Being Fluorinated Selenophene-Vinylene-Selenophenes’. [Abstract]

• G. J. Clarkson, S. Roesner, J. Org. Chem. 2023, 88, 684. ‘Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/S_NAr Reaction Sequence’. [Abstract]

• S. Sathiyalingam, S. Roesner, Adv. Synth. Catal. 2022, 364, 1769. ‘Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/S_NAr Reaction Sequence’. [Abstract]

• C. Dean, S. Roesner, S. Rajkumar, G. J. Clarkson, M. Jones, M.; Shipman, Tetrahedron 2021, 79, 131836. 'Synthesis of sp³-rich Chemical Libraries based upon 1,2-Diazetidines'. [Abstract]

• S. Roesner, J. D. Beadle, L. K. B. Tam, I. Wilkening, G. J. Clarkson, P. Raubo, M. Shipman, Org. Biomol. Chem. 2020, 18, 5400. 'Development of Oxetane Modified Building Blocks for Peptide Synthesis'. [Abstract]

• C. Dean, R. Sundaram, S. Roesner, N. Carson, G. J. Clarkson, M. Wills, M. Jones, M. Shipman, Chem. Sci. 2020, 11, 1636. 'Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality'. [Abstract]

• S. Roesner, G. J. Saunders, I. Wilkening, E. Jayawant, J. V. Geden, P. Kerby, A. M. Dixon, R. Notman, M. Shipman, Chem. Sci. 2019, 10, 2465. ‘Macrocyclisation of Small Peptides Enabled by Oxetane Incorporation’. [Abstract]

• A. Noble, S. Roesner, V. K. Aggarwal, Angew. Chem. Int. Ed. 2016, 55, 15920; Angew. Chem. 2016, 128, 16152. ‘Short Enantioselective Total Synthesis of Tatanan A and 3-epi-Tatanan A Using Assembly-Line Synthesis’. [Abstract]

• S. Roesner, S. L. Buchwald, Angew. Chem. Int. Ed. 2016, 55, 10463; Angew. Chem. 2016, 128, 10619. ‘Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes’. [Abstract]

• S. Roesner, D. J. Blair, V. K. Aggarwal, Chem. Sci. 2015, 6, 3718. ‘Enantioselective Installation of Adjacent Tertiary Benzylic Stereocentres by Using Lithiation–Borylation–Protodeboronation Methodology. Application to the Synthesis of Bifluranol and Fluorohexestrol’. [Abstract]

• S. Roesner, C. A. Brown, M. Mohiti, A. P. Pulis, R. Rasappan, D. J. Blair, S. Essafi, D. Leonori, V. K. Aggarwal, Chem. Commun. 2014, 50, 4053. ‘Stereospecific Conversion of Alcohols into Pinacol Boronic Esters Using Lithiation‒Borylation Methodology with Pinacolborane’. [Abstract]

• S. Roesner, V. K. Aggarwal, Can. J. Chem. 2012, 90, 965. ‘Enantioselective Synthesis of (R)-Tolterodine Using Lithiation/Borylation Methodology’. [Abstract]

• S. Roesner, V. K. Aggarwal, Nature 2012, 487, 48. ‘Organic Chemistry ‒ Reactions at the End of a Tether’. ‘News and Views’ article.

• S. Roesner, J. M. Casatejada, T. G. Elford, R. P. Sonawane, V. K. Aggarwal, Org. Lett. 2011, 13, 5740. ‘Enantioselective Syntheses of (+)-Sertraline and (+)-Indatraline Using Lithiation/Borylation Methodology’. [Abstract]

• S. Roesner, G. Hilt, Synthesis 2011, 662. ‘Substrate-Controlled Regioselective Cobalt(I)-Catalysed 1,4-Hydrovinylation Reactions’. [Abstract]

• L. Kersten, S. Roesner, G. Hilt, Org. Lett. 2010, 12, 4920. ‘Synthesis and Characterization of Polycarbonyl Compounds via their BF2-Adducts’. [Abstract]

Teaching and supervision

I am module leader for the first year course CH161 Introduction to Organic Chemistry. Here, I teach the third part about the chemistry of enols and enolates, alkenes, alkynes and aromatics.

Furthermore, I supervise MChem students (CH401) during their final research project and advise third year students during their Extended Lab exercise (CH3G0).

I am happy to support undergraduate students to apply for the Undergraduate Research Support Scheme (URSS) to conduct an independent research project over the summer months in our research group.