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Electrical polarization enables integrative quality control during bacterial differentiation into spores

iScience jun19Teja Sirec, Jonatan M. Benarroch, Pauline Buffard, Jordi Garcia-Ojalvo, Munehiro Asally

Quality control of offspring is important for the survival of cells. However, the mechanisms by which quality of offspring cells may be checked while running genetic programs of cellular differentiation remain unclear. Here we investigated quality control during sporulating in Bacillus subtilis by combining single-cell time-lapse microscopy, molecular biology and mathematical modelling. Our results revealed that the quality control via premature germination is coupled with the electrical polarization of outer membranes of developing forespores.

iScience. June 2019

Mon 24 Jun 2019, 08:32 | Tags: Biotechnology Biomedical Science