Latest Publications
Arc expression regulates long-term potentiation magnitude and metaplasticity in area CA1 of the hippocampus in ArcKR mice
Haley, Maisy, Bertrand, Jeanri, Anderson, Vanessa Torrico, Fuad, Mukattar, Frenguelli, Bruno G., Corrêa, Sônia A. L. and Wall, Mark J.
Expression of the immediate early gene Arc/Arg3.1 (Arc), a key mediator of synaptic plasticity, is enhanced by neural activity and then reduced by proteasome-dependent degradation. We have previously shown that disruption of Arc degradation, in an Arc knock-in mouse (ArcKR), where the predominant Arc ubiquitination sites were mutated, reduced the threshold to induce, and also enhanced, the strength of Group I metabotropic glutamate receptor-mediated long- term depression (DHPG-LTD). Here we have investigated if ArcKR expression changes long- term potentiation (LTP) in CA1 area of the hippocampus. Our findings support the hypothesis that Arc ubiquitination supports the induction and expression of LTP, likely via limiting Arc-dependent removal of AMPA receptors at synapses.