Job Title
Professor
Department
Life Sciences
Phone
02476 524727
Email
Web Link
Research Interests
Research in the laboratory focuses on the molecular biology of viruses which use a single stranded negative sense RNA molecule as genome. Of particular interest are paramyxoviruses which are responsible acute respiratory infections in their host, though other negative strand viruses are studied for comparison. We have worked for many years on various aspects of the molecular biology of pneumoviruses, which include respiratory syncytial virus, pneumonia virus of mice and avian pneumovirus. Much of our work uses the technique of reverse genetics for analysis of important regulatory sequences controlling virus RNA synthesis and identification of functional domains in proteins involved in virus RNA synthesis. Recently, we have begun work on the protective capacity of specific genome deletions of influenza virus in collaboration with Professor Nigel Dimmock. More details on these viruses and our research interests are available on the Pneumovirus Laboratory website
Biography
BSc (Biochemistry) University of Aberdeen
PhD (Virology) University of Glasgow
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- Smith, C. M., Kulkarni, H., Radhakrishnan, P., Rutman, A., Bankart, M. J., Williams, G., Hirst, R. A., Easton, A. J. (Andrew J.), Andrew, P. W., O'Callaghan, C., 2014. Ciliary dyskinesia is an early feature of respiratory syncytial virus infection. European Respiratory Journal, 43 (2), pp. 485-496
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- Gould, Phillip S., Dyer, Nigel P., Croft, Wayne D., Ott, Sascha, Easton, A. J. (Andrew J.), 2014. Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism. RNA, 20, pp. 373-381
- Behjati, Mohaddeseh, Torktaz, Ibrahim, Mohammadpour, Mehrdad, Ahmadian, Gholamreza, Easton, A. J. (Andrew J.), 2012. Comparative modeling of CCRL1, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein. Bioinformation, Vol.8 (No.7), pp. 336-340
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- Smith, C. M. (Claire M.), Hirst, R. A., Bankart, Michael J. G., Jones, D. W. (David W.), Easton, A. J. (Andrew J.), Andrew, P. W., O'Callaghan, Christopher, 2011. Cooling of cilia allows functional analysis of the beat pattern for diagnostic testing. Chest, Vol.140 (No.1), pp. 186-190
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| Title | Funder | Award start | Award end |
|---|---|---|---|
| Zika virus ? harnessing the powers of molecular and device engineering to counter a global threat | EPSRC | 01 Jun 2016 | 31 Mar 2017 |
| Commercial development of antivirals for bovine respiratory syncytial virus (BBSRC FLIP) | BBSRC | 01 Sept 2014 | 31 Aug 2015 |
| Translation Award: FluPro - a novel flu antiviral | Wellcome Trust | 01 May 2010 | 30 Apr 2015 |
| The Development of Novel Multivalent Vaccines | BBSRC | 17 Jan 2011 | 16 Jan 2015 |
| BBSRC Pathfinder March 2014 - Novel Inhibitors of Bovine Respiratory Syncytial Virus | BBSRC | 01 Jul 2014 | 30 Sept 2014 |
| Phd Studentship Optimisation of current diagnostic capabilities and restrictions to vaccine efficacy for the LyssaviriusesStudents Name: Jenni Evans | Animal Health and Veterinary Laboratories Agency | 01 Nov 2011 | 30 Sept 2014 |
| Analysis of the mechanism for coupled transition in cellular virus mRNAs | BBSRC | 01 Sept 2011 | 31 Aug 2014 |
| Studies of Chromosome Folding in BacteriaResearch Career Development Fellowship for David Grainger | Wellcome Trust | 01 Oct 2008 | 30 Sept 2013 |
| Respiratory Syncytial Virus RNA Helicase Inhibitors | Wellcome Trust | 22 Jul 2013 | 16 Sept 2013 |
| Summer Research Student | NeuroSolutions Limited | 25 Jun 2012 | 19 Aug 2012 |
| Research project to test activity of PTC compounds against respiratory syncytial virus in cell-based assays | PTC Therapeutics, Inc. | 01 Apr 2011 | 31 Mar 2012 |
| Supplement for additional antiviral test work (for summer student) see 30040 RLFAE3005 | PTC Therapeutics, Inc. | 15 Aug 2011 | 30 Sept 2011 |
| Wellcome Trust Value in People Award 2010-11 | Wellcome Trust | 01 Oct 2010 | 30 Sept 2011 |
| Coupled translation | BBSRC | 01 Jan 2008 | 31 Dec 2010 |
| Regulation of Cortical excitability and seizure activity by purines | Epilepsy Research UK | 01 Jan 2008 | 31 Dec 2010 |
| VALUE IN PEOPLE AWARD | Wellcome Trust | 01 Oct 2009 | 30 Sept 2010 |
| Helping the brain itself: D-ribose to promote recovery after stroke | Research into Ageing | 01 Oct 2007 | 30 Sept 2010 |
| Alzheimers Research Trust 2007 Studentship for Ceri Louise Lynn-Adams | Alzheimers Research UK | 01 Oct 2007 | 30 Sept 2010 |
| Properties and in vivo mechanisms of action of cloned influenza virus interfering RNA-a new type of antiviral agent. | MRC | 01 Jan 2007 | 31 Dec 2009 |
| Wellcome Trust VIP Award 2008-2009 | Wellcome Trust | 01 Oct 2008 | 30 Sept 2009 |
| The Application of Reverse genetics to the Study of Pathogenicity in Avian Pneumovirus | BBSRC | 01 Nov 2005 | 30 Oct 2008 |
| Wellcome Trust VIP AwardSplit between BioSCi & WMS - TBC £s | Wellcome Trust | 01 Oct 2007 | 30 Sept 2008 |
| Vacation Bursary for Rosemary Ewans | BBSRC | 19 Jul 2004 | 12 Sept 2004 |
| Real time PCR & high throughput sequencing facilities for biomedical research, microbiology and cell biology | BBSRC | 01 Oct 2003 | 30 Jun 2004 |
| Vacation Studentship for Helena Jane Maier | Society for General Microbiology | 01 Jul 2003 | 20 Aug 2003 |