Research Interests
Our work is concerned with the way that the very first differences arise between the cells of embryos of the anuran amphibian Xenopus . This organism has enormous advantsges for studying embryonic development because it is easy to keep, lays eggs throughout the year, and its externally developing embryos are large and easy to manipulate. Recently we have been focusing on the development of the cells of the yolky half of the embryo, the vegetal pole. These form the endoderm and the primordial germ cells. Our research is concerned with the mechanisms that bring these pathways of development about, and how these pathways are distinguished from that of neighbouring cells which become skin, nervous system, muscles, and so on.
- Nijjar, Sarbjit, Woodland, Hugh R., 2013. Protein interactions in Xenopus germ plasm RNP particles. PLoS ONE, 8 (11)
- Nijjar, Sarbjit, Woodland, Hugh R., 2013. Localisation of RNAs into the germ plasm of vitellogenic xenopus oocytes. PLoS One, 8 (4)
- Venoux, M., Tait, X., Hames, R. S., Straatman, K. R., Woodland, Hugh R., Fry, A. M., 2013. Poc1A and Poc1B act together in human cells to ensure centriole integrity. Journal of Cell Science, 126 (1), pp. 163-175
- Lehtonen, Eero, Woodland, Hugh R., 2012. The 40th anniversary issue of Differentiation?Cilia in development, differentiation and disease. Differentiation, Vol.83 (No.2), pp. S1-S3
- Hames, Rebecca S., Hames, Richard, Prosser, Suzanna L., Euteneuer, Ursula, Lopes, Carla A. M., Moore, Wendy, Woodland, Hugh R., Fry, Andrew M., 2008. Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells. Experimental Cell Research, 314 (3), pp. 574-589
- Woodland, Hugh R., Fry, Andrew M., 2008. Pix proteins and the evolution of centrioles. PLoS One, Vol.3 (No.11)
- Woodland, Hugh R., Zorn, Aaron M., 2008. The core endodermal gene network of vertebrates : combining developmental precision with evolutionary flexibility. BioEssays, 30 (8), pp. 757-765
- Kirilenko, Pavel, Weierud, Frida K., Zorn, Aaron M., Woodland, Hugh R., 2008. The efficiency of Xenopus primordial germ cell migration depends on the germplasm mRNA encoding the PDZ domain protein Grip2. Differentiation, 76 (4), pp. 392-403
- Howard, Laura, Rex, Maria, Clements, Debbie, Woodland, Hugh R., 2007. Regulation of the Xenopus Xsox17 alpha(1) promoter by co-operating VegT and Sox17 sites. Developmental Biology, Vol.310 (No.2), pp. 402-415
- Berekelya, Lyubov A., Mikryukov, Alexander A., Luchinskaya, Natalia N., Ponomarev, Maxim B., Woodland, Hugh R., Belyavsky, Alexander V., 2007. The protein encoded by the germ plasm RNA Germes associates with dynein light chains and functions in Xenopus germline development. Differentiation, Vol.75 (No.6), pp. 546-558
- Woodland, Hugh R., Machado, R., Moore, W., Hames, R., King, M. L., Chang, P., Houliston, E., 2005. Xpat-a protein which functions in the organisation and positioning of Xenopus germ plasm. MECHANISMS OF DEVELOPMENT, pp. S94-S94
| Title | Funder | Award start | Award end |
|---|---|---|---|
| RNA Location in the Xenopus Oocyte | Wellcome Trust | 01 May 2008 | 30 Apr 2011 |
| Investigating Pix protein function | BBSRC | 01 Mar 2008 | 28 Feb 2011 |
| Germes, a novel gene encoding a Xenopus germ plasm associated RNA: Molecular dissection of oocyte and germ plasm formation through identification and characterisation of germes RNA and protein partners | Intas Pharmaceutical | 01 Oct 2006 | 01 Apr 2009 |
| Mechanism of endoderm development in Xenopus. | Wellcome Trust | 01 Jan 2004 | 31 Dec 2006 |
| The function in forming the germ line of the novel gene Xpat | Wellcome Trust | 08 Apr 2005 | 07 Jun 2005 |