Job Title
Professor
Department
Life Sciences
Email
Web Link
Research Interests
My group uses X-ray crystallography as a principal technique to investigate the structural enzymology of
- Oligopeptidases
- Peroxidases and other haem proteins
- Enzymes involved in amino acid biosynthesis
Biography
2015-2018: Member, Life Sciences & Soft Materials Advisory Board of the Science & Technology Facilities Council
2010-2015: Chairman of the Biological Structures Group of the British Crystallographic Association
- 'Mikhaylina, Alevtina, 'Ksibe, Amira Z., 'Wilkinson, Rachael C., 'Smith, Darbi, 'Marks, Eleanor, 'Coverdale, James P. C., 'F?l?p, Vilmos, 'Scanlan, David J., 'Blindauer, Claudia A., 2022. 'A single sensor controls large variations in zinc quotas in a marine cyanobacterium. Nature Chemical Biology, 18, pp. 869-877
- Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J., Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn, Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., Fülöp, Vilmos, Challis, Gregory L., Corre, Christophe, 2021. Molecular basis for control of antibiotic production by a bacterial hormone. Nature, 590 (7846), pp. 463-467
- York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, Fülöp, Vilmos, Dowson, Christopher G., Khalid, Syma, Roper, David I., 2021. Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7), pp. 731-742
- Wilkinson, Rachael C., Rahmanpour, Rahman, Jamshidi, Shirin, Fülöp, Vilmos, Bugg, Timothy D. H., 2020. Extracellular alpha/beta-hydrolase from Paenibacillus species shares structural and functional homology to tobacco salicylic acid binding protein 2. Journal of Structural Biology, 210 (3)
- Wei, Zhen, Wilkinson, Rachael C., Rashid, Goran M. M., Brown, David, Fülöp, Vilmos, Bugg, Tim, 2019. Characterisation of thiamine diphosphate-dependent 4-hydroxybenzoylformate decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5 involved in degradation of aryl-C2 lignin degradation fragments. Biochemistry, 58 (52), pp. 5281-5293
- Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Füllöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L., Lewandowski, Józef R., 2019. Structural basis for chain release from the enacyloxin polyketide synthase. Nature Chemistry, 11, pp. 913-923
- Alkhalaf, Lona M., Barry, Sarah M., Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R., Fülöp, Vilmos, Challis, Gregory L., 2019. Binding of distinct substrate conformations enables hydroxylation of remote sties in thaxtomin D by cytochrome P450 TxtC. Journal of the American Chemical Society, 141 (1), pp. 216-222
- Granja-Travez, R. S., Wilkinson, Rachael C., Persinoti, G. F., Squina, F. M., Fülöp, Vilmos, Bugg, Tim, 2018. Structural and functional characterisation of multi-copper oxidase CueO from lignin-degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate. FEBS Journal, 285 (9), pp. 1684-1700
- Rashid, Goran M. M., Zhang, Xiaoyang, Wilkinson, Rachael C., Fülöp, Vilmos, Cottyn, Betty, Baumberger, Stéphanie, Bugg, Tim, 2018. Sphingobacterium sp. T2 manganese superoxide dismutase catalyses the oxidative demethylation of polymeric lignin via generation of hydroxyl radical. ACS Chemical Biology
- Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, Fülöp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S., Roper, David I., 2017. Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1)
- Rea, Dean, Van Elzen, Roos, De Winter, Hans, Van Goethem, Sebastiaan, Landuyt, Bart, Luyten, Walter, Schoofs, Liliane, Van Der Veken, Pieter, Augustyns, Koen, De Meester, Ingrid, Fülöp, Vilmos, Lambeir, Anne-Marie, 2017. Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling. European Journal of Medicinal Chemistry, 139, pp. 482-491
- Rahmanpour, Rahman, Rea, Dean, Jamshidi, Shirin, Fülöp, Vilmos, Bugg, Tim, 2016. Structure of thermobifida fusca DyP-type peroxidase and activity towards kraft lignin and lignin model compounds. Archives of Biochemistry and Biophysics, 594, pp. 54-60
- Rashid, Goran M. M., Taylor, Charles R. (Charles Robert), Liu, Yangqingxu, Zhang, Xiaoyang, Rea, Dean, Fülöp, Vilmos, Bugg, Tim, 2015. Identification of manganese superoxide dismutase from Sphingobacterium sp. T2 as a novel bacterial enzyme for lignin oxidation. ACS chemical biology, 10 (10), pp. 2286-2294
- Noda-Garcia, Lianet, Camacho-Zarco, Aldo R., Medina-Ruíz, Sophía, Gaytán, Paul, Carrillo-Tripp, Mauricio, Fülöp, Vilmos, Barona-Gómez, Francisco, 2013. Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer. Molecular Biology and Evolution, 30 (9), pp. 2024-2034
- Marlow, Victoria A., Rea, Dean, Najmudin, Shabir, Wills, Martin, Fülöp, Vilmos, 2013. Structure and mechanism of acetolactate decarboxylase. ACS Chemical Biology, 8 (10), pp. 2339-2344
- Szeltner, Zoltán, Juhász, Tünde, Szamosi, Ilona, Rea, Dean, Fülöp, Vilmos, Módos, Károly, Juliano, Luiz, Polgár, László, 2013. The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol.1834 (No.1), pp. 98-111
- Ruane, Karen M., Lloyd, Adrian J., Fülöp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa, Roper, David I., 2013. Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, 288 (46)
- Canning, Peter, Rea, Dean, Morty, Rory E., Fülöp, Vilmos, 2013. Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes. PLoS One, 8 (11)
- Van der Veken, Pieter, Fülöp, Vilmos, Rea, Dean, Gerard, Melanie, Van Elzen, Roos, Joossens, Jurgen, Cheng, Jonathan D., Baekelandt, Veerle, De Meester, Ingrid, Lambeir, Anne-Marie, Augustyns, Koen, 2012. P2-SubstitutedN-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. Journal of Medicinal Chemistry, Vol. 55 (No.22), pp. 9856-9867
- Kaszuba, Karol, Róg, Tomasz, Danne, Reinis, Canning, Peter, Fülöp, Vilmos, Juhász, Tünde, Szeltner, Zoltán, St. Pierre, J.-F., García-Horsman, Arturo, Männistö, Pekka T., Karttunen, Mikko, Hokkanen, Jyrki, Bunker, Alex, 2012. Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase. Biochimie, Vol.94 (No.6), pp. 1398-1411
- Van der Veken, Pieter, Fülöp, Vilmos, Rea, Dean, Gerard, Melanie, Van Elzen, Roos, Joossens, Jurgen, Cheng, Jonathan D., Baekelandt, Veerle, De Meester, Ingrid, Lambeir, Anne-Marie, Augustyns, Koen, 2012. P2-substitutedN-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase : biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy. Journal of Medicinal Chemistry, Vol.55 (No.22), pp. 9856-9867
- Rea, Dean, Fülöp, Vilmos, 2011. Prolyl oligopeptidase structure and dynamics. CNS & Neurological Disorders - Drug Targets, Vol.10 (No.3), pp. 306-310
- Silver, Barry R., Fülöp, Vilmos, Unwin, Patrick R., 2011. Protein crystallization at oil/water interfaces. New Journal of Chemistry, Vol.35 (No.3), pp. 602-606
- Racys, Daurgidas Tomas, Rea, Dean, Fülöp, Vilmos, Wills, Martin, 2010. Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide. Bioorganic & Medicinal Chemistry, Vol.18 (No.13), pp. 4775-4782
- Batson, Sarah, Rea, Dean, Fülöp, Vilmos, Roper, David I., 2010. Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coli. Journal of Experimental Psychology: Human Perception and Performance, Vol.66 (No.4), pp. 405-408
- Noda-Garcia, Lianet, Camacho-Zarco, Aldo R., Verdel-Aranda, Karina, Wright, H. (Helena), Soberon, Xavier, Fülöp, Vilmos, Barona-Gomez, Francisco, 2010. Identification and analysis of residues contained on ß ? a loops of the dual-substrate (ßa)8 phosphoriblosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activity. Protein Science, Vol.19 (No.3), pp. 535-543
- Fülöp, Vilmos, Sam, Katharine A., Ferguson, Stuart J., Ginger, Michael L., Allen, James W. A., 2009. Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase. FEBS Journal, Vol.276 (No.10), pp. 2822-2832
- Wright, H. (Helena), Noda-Garcia, Lianet, Ochoa-Leyva, Adrian, Hodgson, D. A., Fülöp, Vilmos, Barona-Gomez, Francisco, 2008. The structure/function relationship of a dual-substrate (beta alpha)(8)-isomerase. Biochemical and Biophysical Research Communications, 365 (1), pp. 16-21
- Echalier, Aude, Brittain, Thomas, Wright, Joshua, Boycheva, Svetlana, Mortuza, Gulnahar B., Fülöp, Vilmos, Watmough, Nicholas J., 2008. Redox-linked structural changes associated with the formation of a catalytically competent form of the diheme cytochrome c peroxidase from Pseudomonas aeruginosa. Biochemistry, Vol.47 (No.7), pp. 1947-1956
- Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Tim, Roper, David I., 2008. Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry, Vol.47 (No.38), pp. 9955-9965
- Allen, Stuart C. H., Moore, Katherine A. H., Marsden, Catherine J., Fülöp, Vilmos, Moffat, Kevin G., Lord, Mike, Ladds, Graham, Roberts, L. M. (Lynne M.), 2007. The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae.. FEBS Journal, Vol.274 (No.21), pp. 5586-5599
- Jamshad, Mohammed, Murrell, J. C. (J. Colin), Fülöp, Vilmos, 2007. Purification and crystallization of the hydroxylase component of the methanesulfonate monooxygenase from Methylosulfonomonas methylovora strain M2. Protein Expression and Purification, Vol.52 (No.2), pp. 472-477
- Rea, Dean, Fülöp, Vilmos, Bugg, Tim, Roper, David I., 2007. Structure and mechanism of HpcH : a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli. Journal of Molecular Biology, Vol.373 (No.4), pp. 866-876
- Lee, Sarah C., Stoilova-Mcphie, Svetla, Baxter, Laura, Fülöp, Vilmos, Henderson, Janey, Rodger, Alison, Roper, David I., Scott, David J., Smith, Corinne J., Morgan, J. Alun W., 2007. Structural characterisation of the insecticidal toxin XptA1, reveals a 1.15 MDa tetramer with a cage-like structure. Journal of Molecular Biology, Vol.366 (No.5), pp. 1558-1568
- Allen, Stuart C. H., Moore, Katherine A. H., Marsden, Catherine J., Fülöp, Vilmos, Moffat, Kevin G., Lord, Mike, Ladds, Graham, Roberts, L. M. (Lynne M.), 2007. The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae. FEBS JOURNAL, 274 (21), pp. 5586-5599
- Rea, Dean, Hazell, Carole, Andrews, Norma W., Morty, Rory E., Fülöp, Vilmos, 2006. Expression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei. Acta Crystallographica Section F - Structural Biology and Crystallization Communications, Vol.62 (Part 8), pp. 808-810
- Brittain, Thomas, Boyd, P.D.W., Fülöp, Vilmos, Echalier, Aude, 2008. The mechanism of action of di-heme peroxidases: a theoretical study. In Inorganic biochemistry: research progress, Lancaster, Nova Science, pp. 225-242
- Kosol, Simone, Gallo, Angelo, Griffiths, Daniel, Valentic, Timothy R., Masschelein, Joleen, Jenner, Matthew, de los Santos, Emmanuel L. C., Manzi, Lucio, Sydor, Paulina K., Rea, Dean, Zhou, Shanshan, Fülöp, Vilmos, Oldham, Neil J., Tsai, Shiou-Chuan, Challis, Gregory L., Lewandowski, Józef R., 2019. Data for Structural basis for chain release from the enacyloxin polyketide synthase. Department of Chemistry, University of Warwick
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Mechanistic Enzymology of Bacterial Lignin Degradation | BBSRC | 01 Oct 2014 | 31 Jul 2018 |
| Subproject for Institution # 39462 | BBSRC | 01 Oct 2014 | 31 Jan 2018 |
| NEUROPRO | European Commission | 01 Jul 2008 | 30 Jun 2012 |
| Human African Trypanosomiasis | Advantage West Midlands | 17 Sept 2009 | 19 Sept 2009 |
| Structural Insights into the Convergent Evolution of TIM- barrels | Royal Society | 01 Oct 2006 | 30 Sept 2008 |
| MAR Imaging plate x ray data collection system | Wellcome Trust | 01 Sept 2003 | 31 Aug 2008 |
| Towards a complete structure-function description of an aromatic degradative pathway | BBSRC | 01 Feb 2005 | 31 Jan 2008 |
| Light-regulated gene expression in Myxococcus xanthus: the mechanism of action of anti-repressor CarS on repressor CarA | BBSRC | 01 Jan 2004 | 31 Dec 2006 |
| Structural basis of oligopeptidase regulation and catalysis: acylaminoacyl peptidase | Wellcome Trust | 01 Jan 2002 | 31 Dec 2004 |
| Dr V Fulop - Royal Society Research Fellowship. | Royal Society | 01 Jan 1998 | 30 Sept 2004 |
| Dr V Fulop - Royal Society Research Fellowship. | Royal Society | 01 Jan 1998 | 30 Sept 2004 |
| Dr V Fulop - Royal Society Research Fellowship. | Royal Society | 01 Jan 1998 | 30 Sept 2004 |
| Dr V Fulop - Royal Society Research Fellowship. | Royal Society | 01 Jan 1998 | 30 Sept 2001 |