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Dr Andrew Nelson

 

Title   

Assistant Professor
 

Contact   

Life Sciences
University of Warwick
Coventry
CV4 7AL
Tel: 024 765 74523
Email: A.Nelson.1@warwick.ac.uk

Research Interests

The endoderm, one of the three primary germ layers in the early vertebrate embryo makes direct contributions to several organs including liver, pancreas, and the digestive and respiratory tracts. Correct endodermal gene expression is also required to pattern neighbouring tissues, such as the developing heart and craniofacial structures. The primary goal of my research is to understand how gene regulatory networks control the specification of endoderm and its diversification into a range of different cell types. A secondary objective is to understand how the endoderm acts to pattern surrounding tissues. To address these questions I use both zebrafish embryos and differentiating mouse embryonic stem cells as model systems, combined with genetic, functional genomic and transcriptiomic approaches.

An understanding of endoderm formation and its interactions with neighbouring cell populations will lead to refined regenerative medicine strategies for replacement of faulty hepatic and pancreatic tissues, and facilitate pre-natal diagnosis of cardiac defects.


Biography

PhD, Biology, Wellcome Trust Sanger Institute/University of Cambridge, 2009
BSc (Hons), Applied Biochemistry, University of Liverpool, 2004

Member of the British Society for Developmental Biology

Publications

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Research Themes

Biomedical Science