Job Title
Associate Professor
Department
Chemistry
Phone
02476 523 557
Email
Web Link
Research Interests
Characterisation of microbial transcriptional regulators that control antibiotic biosynthesis in actinomycetes
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for antibiotic drug discovery: activating silent biosynthetic pathways via genetic manipulations or using elicitors of antibiotic productions in Streptomyces and Rhodococcus bacteria
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for developing new tools for synthetic biology: orthogonal inducible expression systems
Biography
Associate Professor, University of Warwick (2015 - present)
Assistant Professor, University of Warwick (2013 - 2015)
Royal Society University Research Fellowship (2010 - present)
Wellcome Trust, Value in People Research Fellowship (2009-2010)
PDRA, University of Warwick (2004-2009)
PhD in Chemical Biology, University of Exeter (2000 - 2004)
- Alberti, Fabrizio, Leng, Daniel J., Wilkening, Ina, Song, Lijiang, Tosin, Manuela, Corre, Christophe, 2019. Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery. Chemical Science, 10 (2), pp. 453-463
- Alberti, Fabrizio, Corre, Christophe, 2019. Editing streptomycete genomes in the CRISPR/Cas9 age. Natural Product Reports, 36 (9), pp. 1237-1248
- Li, Xiao, Wang, Juan, Shi, Mingxin, Wang, Weishan, Corre, Christophe, Yang, Keqian, 2017. Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. Applied Microbiology and Biotechnology, 101 (13), pp. 5333-5340
- Bowyer, Jack E., LC. de los Santos, Emmanuel, Styles, Kathryn, Fullwood, Alex, Corre, Christophe, Bates, Declan, 2017. Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor. Journal of Biological Engineering, 11 (1)
- Wang, Weishan, Yang, Tongjian, Li, Yihong, Li, Shanshan, Yin, Shouliang, Styles, Kathryn, Corre, Christophe, Yang, Keqian, 2016. Development of a synthetic oxytetracycline-inducible expression system for streptomycetes using de novo characterized genetic parts. ACS Synthetic Biology, 5 (7), pp. 765-773
- Sidda, John D., Poon, Vincent, Song, Lijiang, Wang, Weishan, Yang, Keqian, Corre, Christophe, 2016. Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. Organic and Biomolecular Chemistry, 14, pp. 6390-6393
- Tang, Kunkun, Beccantini, Alberto, Corre, Christophe, 2014. Combining discrete equations method and upwind downwind-controlled splitting for non-reacting and reacting two-fluid computations : one dimensional case. Computers & Fluids, 93, pp. 74-90
- Song, Lijiang, Laureti, Luisa, Corre, Christophe, Leblond, Pierre, Aigle, Bertrand, Challis, Gregory L., 2014. Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis. The Journal of Antibiotics, 67 (1), pp. 71-76
- Sidda, John D., Song, Lijiang, Poon, Vincent, Al-Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L., Corre, Christophe, 2014. Discovery of a family of ?-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Science, 5, pp. 86-89
- Sidda, John D., Song, Lijiang, Poon, Vincent, Al Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L., Corre, Christophe, 2013. Discovery of a family of ?-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Sciences, 5 (1), pp. 86-89
- Song, Lijiang, Laureti, L., Gomez-Escribano, J. P., Fox, David J., Yeo, V., Corre, Christophe, Huang, S., Leblond, P., Aigle, B., Bibb, M., Challis, Gregory L., 2012. Bacterial genome mining for novel natural product discovery. Planta Medica, 78 (11)
- Sidda, John D., Corre, Christophe, 2012. Gamma-butyrolactone and furan signaling systems in streptomyces. Methods in Enzymology, Vol.517, pp. 71-87
- Aigle, Bertrand, Corre, Christophe, 2012. Waking up streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors. Methods in Enzymology, Vol.517, pp. 343-366
- Corre, Christophe, Haynes, Stuart W., Malet, Nicolas, Song, Lijiang, Challis, Gregory L., 2011. A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically C-13-labelled glycerols. Chemical Communications, Vol.46 (No.23), pp. 4079-4081
- Bunet, R., Song, Lijiang, Mendes, M. V., Corre, Christophe, Hotel, L., Rouhier, N., Framboisier, X., Leblond, Pierre, Challis, Gregory L., Aigle, B., 2011. Characterization and manipulation of the pathway-specific late regulator AlpW reveals streptomyces ambofaciens as a new producer of kinamycins. Journal of Bacteriology, Vol.193 (No.5), pp. 1142-1153
- Laureti, L., Song, Lijiang, Huang, S., Corre, Christophe, Leblond, Pierre, Challis, Gregory L., Aigle, B., 2011. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proceedings of the National Academy of Sciences of the United States of America, Vol.108 (No.15), pp. 6258-6263
- Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang, Challis, Gregory L., 2011. Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5), pp. 388-392
- Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe, Song, Lijiang, Challis, Gregory L., 2011. Stereochemical elucidation of streptorubin B. Journal of the American Chemical Society, Vol.133 (No.6), pp. 1793-1798
- O'Rourke, S. (Sean), Wietzorrek, Andreas, Fowler, Kay, Corre, Christophe, Challis, Gregory L., Chater, K. F., 2009. Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Molecular Microbiology, Vol.71 (No.3), pp. 763-778
- Corre, Christophe, Song, Lijiang, O'Rourke, S. (Sean), Chater, K. F., Challis, Gregory L., 2008. 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45), pp. 17510-17515
- Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A., Challis, Gregory L., 2008. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2), pp. 137-148
- Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L., Cole, Richard B., 2008. Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.19 (No.12), pp. 1856-1866
- Stanley, Anna E., Walton, Laura J., Zerikly, Malek Kourdi, Corre, Christophe, Challis, Gregory L., 2006. Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chemical Communications, pp. 3981-3983
- Song, Lijiang, Barona-Gomez, Francisco, Corre, Christophe, Xiang, Longkuan, Udwary, Daniel W., Austin, Michael B., Noel, Joseph P., Moore, Bradley S., Challis, Gregory L., 2006. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society, 128 (46), pp. 14754-14755
- Corre, Christophe, Challis, Gregory L., 2005. Evidence for the unusual condensation of a diketide with a pentulose in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2). Chembiochem, 6 (12), pp. 2166-2170
- Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe, Challis, Gregory L., 2011. Elucidation of pathways for antibiotic biosynthesis in streptomyces coelicolor A3(2). In Wrigley, Stephen (ed.), Functional Molecules from Natural Sources, Cambridge, Royal Society of Chemistry, pp. 149-160
- Aigle, B., Bunet, R., Corre, Christophe, Garenaux, Amélie, Hotel, L., Huang, S., Laureti, L., Lautru, Sylvie, Mendes, V. M., Nezbedová, S., Nguyen, H., Song, Lijiang, Challis, Gregory L., Leblond, Pierre, Pernodet, Jean-Luc, 2011. Genome-guided exploration of streptomyces ambofaciens secondary metabolism. In Streptomyces : molecular biology and biotechnology, Wymondham, Caister Academic, pp. 179-194
- Corre, Christophe, Challis, Gregory L., 2010. Exploiting genomics for new natural product discovery in prokaryotes. In Mander, Lewis N.; Liu, Hung-wen, 1952- (eds.), Comprehensive natural products II : chemistry and biology, Amsterdam ; Boston, Elsevier, pp. 429-453
- Walton, Laura J., Corre, Christophe, Challis, Gregory L., 2006. Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites. Joint 8th Symposium on the Genetics and Molecular Biology of Industrial Microorganisms/8th International Conference on Biotechnology of Microbial Products, San Diego, USA, 14-18 Vov2004, Published in Journal of Industrial Microbiology and Biotechnology, pp. 105-120
- Corre, Christophe, 2013. In search of the missing ligands for TetR family regulators. Chemistry & Biology, Cell Press, pp. 140-142
- Malet, Nicolas, Song, Lijiang, Corre, Christophe, Challis, Gregory L., 2011. Structure-activity relationship and biosynthesis of signaling molecules controlling methylenomycin antibiotic production in Streptomyces coelicolor. American Chemical Society. Abstracts of Papers (at the National Meeting), American Chemical Society
- Corre, Christophe, Challis, Gregory L., 2009. New natural product biosynthetic chemistry discovered by genome mining. Natural Product Reports, Royal Society of Chemistry, pp. 977-986
- Corre, Christophe, Challis, Gregory L., 2007. Heavy tools for genome mining. Chemistry & Biology, Cell Press, pp. 7-9
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Terahertz skinometer for improved cancer prevention and treatment | EPSRC | 01 Apr 2019 | 31 Mar 2022 |
| Combatting Antimicrobial Resistance Training Network | European Commission | 01 Jan 2018 | 31 Dec 2021 |
| Engineering a yeast cell factory for production of valuable meroterpenoids. Early Career Fellowship for Dr Fabrizio Alberti | Leverhulme Trust | 01 Nov 2018 | 31 Oct 2021 |
| Warwick Integrative Synthetic Biology Centre (WISB) | BBSRC | 14 Nov 2014 | 31 May 2020 |
| Novel inducible gene expression systems based on furan inducers and the MmfR transcriptional rerpessor | BBSRC | 01 Jun 2015 | 30 Apr 2019 |
| Genome mining of marine bacteria for novel bioactive natural products 2016 China NSFC Costshare | Royal Society | 01 Mar 2017 | 30 Mar 2019 |
| 16ALERT: Mid-Range Equipment Initiative: A high sensitivity triple quadruple mass spectrometer coupled to an ultra-high pressure liquid chromatograph system for quantitative analysis | BBSRC | 01 Jul 2017 | 30 Jun 2018 |
| Discovery of antimicrobials active against Clostridium difficile from actinomycete gene clusters. MLSRF bursary for Dr Fabrizio Alberti | Medical and Life Sciences Research Fund | 01 Jun 2017 | 30 Nov 2017 |
| Developing World Scholarship for Attah Francis Alfred Unuagbe: Characterising and exploiting putative antimicrobial cyclotides from Rinorea dentata used in Nigerian ethnomedicine | Royal Society of Chemistry | 01 Oct 2016 | 31 Dec 2016 |
| Characterising and exploiting cyclotides from Nigerian ethnomedicinal plants | EPSRC | 01 Aug 2016 | 01 Dec 2016 |
| Establishing the potential of biosynthetic urea-synthetases as industrial biocatalysts | BBSRC | 01 May 2016 | 31 Oct 2016 |
| Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics | BBSRC | 01 Sep 2013 | 30 Sep 2016 |
| New Chemical Keys to unlock microbial antibiotics- University Research Fellowship | Royal Society | 01 Oct 2010 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- URF (Supplemental) | Royal Society | 25 Jan 2012 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- University Research Fellowship | Royal Society | 01 Oct 2010 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- URF (Supplemental) | Royal Society | 22 Feb 2013 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- University Research Fellowship (supplement) | Royal Society | 10 Apr 2014 | 30 Sep 2015 |
| Co-crystallisation of transcriptional repressors and synthetic oligonucleotides | Royal Society | 01 Apr 2012 | 31 Mar 2014 |
| New Chemical Keys to unlock microbial antibiotics- URF (Supplemental) | Royal Society | 21 Nov 2011 | 30 Sep 2012 |
| International travel grant- Chemistry and Health | Royal Society | 04 Jun 2011 | 10 Jun 2011 |
| Elucidation of the Unusual Methylenomycin Biosynthetic Pathway in Streptomyces Coelicolor. | BBSRC | 01 Jul 2006 | 30 Jun 2009 |