Current research in the lab is particularly focused on Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).
TB remains the single most important bacterial cause of morbidity and mortality in the world. Almost one-third of the world's population is infected with the TB bacillus and almost 2 million people die from TB each year. Treatment for TB is complicated and requires that at least three drugs be taken concomitantly for six to nine months, often with unpleasant side effects. Consequently a number of multi-drug and extensively-drug resistant strains for TB have emerged, which further complicates and prolongs treatment. In some cases no successful chemotherapy regimens remain. TB, in combination with immuno-compromised individuals, particularly individuals with HIV, represents a serious health problem. Therefore there is an urgent need to understand how Mtb is able to survive and cause infection.
My research is currently focused on understanding how Mtb uses and metabolises sugars using a multidisciplinary approach encompassing biochemistry, structural biology, chemistry and microbiology techniques. We are also interested in the development of novel antimicrobial agents and detection of infectious agents.
Sir Henry Dale Fellow, School of Life Sciences, University of Warwick,
Leverhulme Trust Early Career Fellow, School of Life Sciences, University of Warwick, UK
Postdoctoral Research Fellow, School of Biosciences, University of Birmingham, UK,
Postdoctoral Research Fellow, Global Health Institute, EPFL, Switzerland.
DPhil, Departments of Pharmacology and Chemistry, University of Oxford, UK,
MSc Pharmacology, Department of Pharmacology, University of Oxford, UK
MChem Chemistry, University of Oxford, UK
- Parker, Hadyn, Tomás, Ruben M. F., Furze, Christopher M., Guy, Collette S., Fullam, Elizabeth, 2020. Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria. Organic & Biomolecular Chemistry, pp. 3607-3612
- Guy, Collette S., Gibson, Matthew I., Fullam, Elizabeth, 2019. Targeting extracellular glycans : tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis. Chemical Science, 10 (23), pp. 5935-5942
- Guy, Collette S., Murray, Kathryn, Gibson, Matthew I., Fullam, Elizabeth, 2019. Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry, 17 (43), pp. 9524-9528
- Fenn, Jonathan S., Nepravishta, Ridvan, Guy, Collette S., Harrison, James, Angulo, Jesus, Cameron, Alexander, Fullam, Elizabeth, 2019. Structural basis of glycerophosphodiester recognition by the mycobacterium tuberculosis substrate-binding protein UgpB. ACS Chemical Biology, 14 (9), pp. 1879-1887
- Radhakrishnan, Anjana, Furze, Christopher M., Ahangar, Mohd Syed, Fullam, Elizabeth, 2018. A GFP-strategy for efficient recombinant protein overexpression and purification in Mycobacterium smegmatis. RSC Advances, 8 (58), pp. 33087-33095
- Ahangar, Mohd Syed, Furze, Christopher M., Guy, Collette S., Cooper, Charlotte, Maskew, Kathryn S, Graham, Benjamin T., Cameron, Alexander, Fullam, Elizabeth, 2018. Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA). Journal of Biological Chemistry, 293 (25), pp. 9770-9783
- Richards, Sarah-Jane, Isulfi, Klea, Wilkins, Laura E., Lipecki, Julia, Fullam, Elizabeth, Gibson, Matthew I., 2017. Multivalent antimicrobial polymer nanoparticles target mycobacteria and gram-negative bacteria by distinct mechanisms. Biomacromolecules, 19 (1), pp. 256-264
- Phillips, Daniel J., Harrison, James, Richards, Sarah-Jane, Mitchell, Daniel E., Tichauer, Esther, Hubbard, Alasdair T. M., Guy, Collette S., Hands-Portman, Ian, Fullam, Elizabeth, Gibson, Matthew I., 2017. Evaluation of the antimicrobial activity of cationic polymers against mycobacteria : toward antitubercular macromolecules. Biomacromolecules, 18 (5), pp. 1592-1599
- Guy, Collette S., Tichauer, Esther, Kay, Gemma L., Phillips, Daniel J., Bailey, Trisha L., Harrison, James, Furze, Christopher M., Millard, Andrew D., Gibson, Matthew I., Pallen, Mark J., Fullam, Elizabeth, 2017. Identification of the anti-mycobacterial functional properties of piperidinol derivatives. British Journal of Pharmacology, 174 (14), pp. 2183-2193
- Otten, Lucienne, Fullam, Elizabeth, Gibson, Matthew I., 2016. Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile. Molecular BioSystems, 12 (2), pp. 341-344
- Fullam, Elizabeth, Prokes, Ivan, Fütterer, Klaus, Besra, Gurdyal S., 2016. Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars. Open Biology
- Lowery, Richard, Gibson, Matthew I., Thompson, Richard C., Fullam, Elizabeth, 2015. Deuterated carbohydrate probes as ?label-free' substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis. Chemical communications, 51 (23), pp. 4838-4841
- Richards, Sarah-Jane, Fullam, Elizabeth, Besra, Gurdyal S., Gibson, Matthew I., 2014. Discrimination between bacterial phenotypes using glyco-nanoparticles and the impact of polymer coating on detection readouts. Journal of Materials Chemistry B, 2 (11), pp. 1490-1498
- Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, Russell, Angela, Morris, Garrett, Finn, Paul, Sim, Edith, 2014. Exploration of piperidinols as potential antitubercular agents. Molecules, 19 (10), pp. 16274-16290
- Gibson, Matthew I., Neres, João, Fullam, Elizabeth, 2014. Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor. Carbohydrate research, 391, pp. 61-65
- Fullam, Elizabeth, Talbot, James, Abuhammed, Areej, Westwood, Isaac, Davies, Stephen G., Russell, Angela J., Sim, Edith, 2013. Design, synthesis and structure?activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, Vol.23 (No.9), pp. 2759-2764
- Otten, Lucienne, Richards, Sarah-Jane, Fullam, Elizabeth, Besra, Gurdyal S., Gibson, Matthew I., 2013. Gold nanoparticle-linked analysis of carbohydrate?protein interactions, and polymeric inhibitors, using unlabelled proteins; easy measurements using a ?simple' digital camera. Journal of Materials Chemistry B, 1 (20), pp. 2665-2672
- Abuhammad, Areej, Fullam, Elizabeth, Lowe, Edward D., Staunton, David, Kawamura, Akane, Westwood, Isaac, Bhakta, Sanjib, Garner, Alun Christopher, Wilson, David L., Seden, Peter T., Davies, Stephen G., Russell, Angela J., Garman, Elspeth F., Sim, Edith, 2012. Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. PLoS One, 7 (12)
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Neres, J., Pojer, F., Molteni, E., Chiarelli, L. R., Dhar, N., Boy-Rottger, S., Buroni, S., Fullam, Elizabeth, Degiacomi, G., Lucarelli, A. P., Read, R. J., Zanoni, G., Edmondson, D. E., De Rossi, E., Pasca, M. R., McKinney, J. D., Dyson, P. J., Riccardi, G., Mattevi, A., Cole, S. T. et al (Select to open full list), 2012.
- Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Jones, T. Alwyn, Cole, Stewart T., 2012. Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme. Open Biology, 2 (110026)
- Fullam, Elizabeth, Abuhammad, Areej, Wilson, David L., Anderton, Matthew C., Davies, Steve G., Russell, Angela J., Sim, Edith, 2011. Analysis of ß-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, 21 (4), pp. 1185-90
- Westwood, Isaac M., Bhakta, Sanjib, Russell, Angela J., Fullam, Elizabeth, Anderton, Matthew C., Kawamura, Akane, Mulvaney, Andrew W., Vickers, Richard J., Bhowruth, Veemal, Besra, Gurdyal S., Lalvani, Ajit, Davies, Stephen G., Sim, Edith, 2010. Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.. Protein & Cell, 1 (1), pp. 82-95
- Abuhammad, Areej M., Lowe, Edward D., Fullam, Elizabeth, Noble, Martin, Garman, Elspeth F., Sim, Edith, 2010. Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site. Protein & Cell, 1 (4), pp. 384-92
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Makarov, Vadim, Manina, Giulia, Mikusova, Katarina, Möllmann, Ute, Ryabova, Olga, Saint-Joanis, Brigitte, Dhar, Neeraj, Pasca, Maria Rosalia, Buroni, Silvia, Lucarelli, Anna Paola, Milano, Anna, De Rossi, Edda, Belanova, Martina, Bobovska, Adela, Dianiskova, Petronela, Kordulakova, Jana, Sala, Claudia, Fullam, Elizabeth, Schneider, Patricia, McKinney, John D et al (Select to open full list), 2009.
- Sandy, James, Holton, Simon, Fullam, Elizabeth, Sim, Edith, Noble, Martin, 2009. Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein science : a publication of the Protein Society, 14 (3), pp. 775-782
- Fullam, Elizabeth, Kawamura, Akane, Wilkinson, Helen, Abuhammad, Areej, Westwood, Isaac, Sim, Edith, 2009. Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis. The Protein Journal, 28 (6), pp. 281-293
- Sim, Edith, Sandy, James, Evangelopoulos, Dimitrios, Fullam, Elizabeth, Bhakta, Sanjib, Westwood, Isaac, Krylova, Anna, Lack, Nathan, Noble, Martin, 2008. Arylamine N-acetyltransferases in mycobacteria. Current drug metabolism, 9 (6), pp. 510-519
- Sim, Edith, Lack, Nathan, Wang, Chan-Ju, Long, Hilary, Westwood, Isaac, Fullam, Elizabeth, Kawamura, Akane, 2008. Arylamine N-acetyltransferases : structural and functional implications of polymorphisms. Toxicology, 254 (3), pp. 170-83
- Lack, Nathan A, Kawamura, Akane, Fullam, Elizabeth, Laurieri, Nicola, Beard, Stacey, Russell, Angela J, Evangelopoulos, Dimitrios, Westwood, Isaac, Sim, Edith, 2008. Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. The Biochemical journal, 418 (2), pp. 369-78
- Sim, Edith, Westwood, Isaac, Fullam, Elizabeth, 2007. Arylamine N-acetyltransferases. Expert Opinion on Drug Metabolism & Toxicology, 3 (2), pp. 169-84
- Fullam, Elizabeth, Westwood, Isaac M., Anderton, Matthew C., Lowe, Edward D., Sim, Edith, Noble, Martin E. M., 2007. Divergence of cofactor recognition across evolution : coenzyme A binding in a prokaryotic arylamine N-acetyltransferase. Journal of Molecular Biology, 375 (1), pp. 178-91
- Arisandy, Christofer, Fullam, Elizabeth, Barlow, Stephen, 2006. Comparison of the bis(ferrocenylethynyl)phenylmethylium cation with bis(ferrocenylethenyl)methylium analogues. Journal of Organometallic Chemistry, 691 (15), pp. 3285-3292
- Westwood, I. M., Kawamura, A., Fullam, Elizabeth, Russell, A. J., Davies, S. G., Sim, E., 2006. Structure and mechanism of arylamine N-acetyltransferases. Current topics in medicinal chemistry, 6 (15), pp. 1641-1654