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Professor Elizabeth Wellington

Job Title
Professor
Department
Life Sciences
Phone
76523184
Research Interests

Professor Liz Wellington is an active member of the Environment theme within the School of Life Sciences at the University of Warwick. She holds a personal chair and, with her research group, is involved in the study of bacteria in soil and survival of pathogenic bacteria in the environment. Research work focuses on understanding the ecological roles for specific bacterial activities including antibiotic production, resistance and exoenzyme production and analysing the impact of lateral gene transfer. During the past decade expertise has been developed in the detection, quantification and analysis of soil microbial communities, including the identification of pathogen reservoirs outside of their hosts. Her group was one of the first to report the molecular detection of antibiotic biosynthesis in soil and co-evolution of resistance in non-producers. Subsequent work indicated that waste disposal practices further disseminate antibiotic resistance gene into the environment. Studying the fate of introduced bacteria in the environment has focused on the survival of pathogens such as Salmonella species, MRSA, Dichelobacter nodosus and slow growing mycobacteria including the M. tuberculosis complex. Recent research produced the first non-invasive methods for monitoring shedding in wild life and cattle infected with bTB in order to elucidate the impact of control measures on transmission.

Research Interests:

  • Antibiotic resistance dissemination, aim to identify reservoirs of drug resistance in the environment
  • Defining environmental reservoirs of pathogenic bacteria in soil and water
  • Biodegradation of recalcitrant compounds and biopolymers in the environment
  • Microbial community analysis and specific expertise in the development of environmental proteomics for extraction and analysis of enzymes from soils and wastes, and in the processing of biopolymers
  • Metagenomics and analyses of microbial gene pools in soil; discovery of novel antibiotic gene clusters
Biography

PhD University of Liverpool 1980

  • Ul-Hassan, Atiya, Wellington, E. M. H., 2009. Actinobacteria. In Encyclopedia of Microbiology, Elsevier, pp. 25-44
  • Rossello, M. R., Griffiths, Nathan, Kalvala, Sara, Wellington, E. M. H., Gaze, William H., 2009. Networking strategies in streptomyces coelicolor. 2nd International Conference on Bioinformatics and Systems Biology (BSB 2009), Leipzig, Germany, 23-25 March 2009
  • Edwards, L., Hicks, S., Furman, M., O'Neill, C., Wellington, E. M. H., Torrente, F., Fitzhenry, R., Phillips, A., Murch, Simon, 2007. Seg/I producing Staphylococcus aureus induces intestinal epithelial cytopathy independent of T cell responses. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, Barcelona, Spain, May 9-12, 2007, Published in Journal of Pediatric Gastroenterology and Nutrition, pp. 118-118
Title Funder Award start Award end
CENTA Doctoral Training Partnership (led by Birmingham) NERC 01 Oct 2014 30 Sep 2023
Microbial hitch-hikers of marine plastics: the survival, persistence & ecology of microbial communities in the 'Plastisphere' NERC 14 Jan 2019 13 Jan 2023
HT MTA with Arden Tissue Bank to recieve blood samples University Hospitals Coventry and Warwickshire NHS Trust 14 Mar 2019 13 Mar 2022
Combatting Antimicrobial Resistance Training Network European Commission 01 Jan 2018 31 Dec 2021
Strain resolved metagenomics for medical microbiology MRC 01 Oct 2019 30 Sep 2021
LinkPI: Linking Phenotype function with Identity: a novel integrated single-cell technology and metagenomics approach - Nerc Global Partnership seedcorn fund NERC 01 Nov 2018 31 Aug 2020
FAPIC - Fast Assay for Pathogen Identification and Characterisation (v2) European Commission 01 Jun 2015 31 May 2020
UK Thailand - Overcoming the opportunistic pathogen Acinetobacter baumannii in Thailand? developing bacteriophages as antimicrobial agents British Council 01 Apr 2018 31 Mar 2020
New approaches to resolving community metaproteomes: ComProt NERC 01 Jan 2019 31 Dec 2019
Chicken or the Egg: Is AMR in the Environment Driven by Dissemination of Antibiotics or Antibiotic Resistance Genes? NERC 01 May 2016 31 Dec 2019
Phosphorus cycling in the soil-microbe-plant continuum of agri-ecosystems BBSRC 31 Dec 2014 31 Jul 2019
The farm environment: an overlooked reservoir of Mycobacterium bovis? BBSRC 01 Apr 2016 31 May 2019
MRC-KHIDI UK-KOREA PARTNERING AWARDS -Exploring the relationship between antibiotic persistence and antibiotic resistance in exposed bacteria in environmental locations MRC 31 May 2018 30 Apr 2019
Using next generation sequencing to reveal human impact on aquatic reservoirs of antibiotic resistant bacteria at the catchment scale NERC 04 May 2015 31 Dec 2018
Programme Integration Group (PIG) - Using next generation sequencing to reveal human impact on aquatic reservoirs of antibiotic resistant bacteria at the catchment scale NERC 01 Jul 2017 31 Dec 2018
MRC AMR Development Grant application - AMREPAK: Novel inter-disciplinary approaches for identifying and tackling the spread of AntiMicrobial Resistance through Environmental pathways in PAKistan MRC 01 Oct 2017 31 Mar 2018
Diversity of chlamydia and other bacterial species within amoebae isolated from river sediments - Harry Smith Vacation Studentship Chandara Olgunsoy Microbiology Society 11 Jul 2016 10 Jul 2017
Community Network in metagenomics: The exploitation of metagenomics and meta-omics approaches in life science research BBSRC 01 Feb 2014 31 May 2017
PhD scholarship for Jenny Johnson under the British Council Newton-Mosharafa Fund Title: Metagenomic analysis in gauging the innate microbial community structure and metabolic potential of a contaminated site - A study towards bioremediation British Council 01 Apr 2016 31 Mar 2017
Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics BBSRC 01 Sep 2013 30 Sep 2016
TRAIN-ASAP 2011 European Commission 01 Jan 2012 19 Sep 2016
KTP Partnership with Biome Technologies PLC Technology Strategy Board 01 Jul 2013 30 Jun 2016
KTP Partnership with Biome Technologies PLC - Life Science Component of 36502 Technology Strategy Board 01 Jul 2013 30 Jun 2016
Agreement for the joint funding of a drug development programme NERC 01 Apr 2013 31 Mar 2016
Detection of Mycobacterium bovis in badger faeces: an inter-laboratory comparison study Department for Environment, Food and Rural Affairs 17 Oct 2014 16 Oct 2015
Exploitation of novel metabolites from Antarctic metagenomes (MyIP383) - NERC Innovation Fund (Application for part A Funding ) NERC 01 Jul 2014 31 Aug 2015
Tuberculosis epidemiology and novel transmission routes in rural Tanzania (NIH grant via University of California - Year 5) National Institutes of Health 01 Jul 2014 30 Jun 2015
Optimisation of sampling strategies for improving sensitivity of M. bovis detection by PCR (SE3280) - (Extension to RLFEW3011) Department for Environment, Food and Rural Affairs 19 Aug 2014 18 Oct 2014
Continued development of M. bovis detection in badger faeces by PCR (DEFRA extension RLFEW3011) Department for Environment, Food and Rural Affairs 08 Feb 2014 19 Aug 2014
Strategic Environmental Science Capital Call NERC 01 Jan 2014 30 Jun 2014
NIH grant via University of California - Year 4 National Institutes of Health 01 Jul 2013 30 Jun 2014
Development of Metaproteomics for In-situ Investigation of Microbial Activity both in Vivo and in Soil and Faeces BBSRC 01 May 2010 30 Apr 2014
METAEXPLORE- Metagenomics for bioexploration- Tools and application EU 01 May 2009 30 Apr 2014
Proposed extension to RLFEW3011 (30437)Optimisation of sampling strategies for improving sensitivity of M. bovis detection by PCR Department for Environment, Food and Rural Affairs 12 Nov 2013 11 Feb 2014
Unrestricted Research Grant from Biome Bioplastics Ltd Biome Bioplastics Ltd 15 Jul 2013 31 Jan 2014
NIH Grant via University of California: Year 3 National Institutes of Health 01 Jul 2012 30 Jun 2013
Optimisation of sampling strategies for improving sensitivity of M. bovis detection by PCR Department for Environment, Food and Rural Affairs 01 Sep 2011 30 Nov 2012
Studentship Luci Witcomb - In situ analysis of the microbial community associated with footrot of sheep Pfizer Limited 01 Oct 2008 30 Sep 2012
Tuberculosis epidemiology and novel transmission routes in rural Tanzania (Year 2) National Institutes of Health 01 Jul 2011 30 Jun 2012
Supplement to: NIH Grant via University of California: Year 2 National Institutes of Health 01 Jul 2011 30 Jun 2012
The ecology of protist associated human pathogens NERC 01 Mar 2011 31 May 2012
Global Metabolic Switching in Streptomyces Coelicolor. BBSRC 01 Dec 2006 17 Nov 2011
BBSRC India Partnering Award (IndiaPA) 2008 BBSRC 01 Sep 2009 31 Aug 2011
Tuberculosis epidemiology and novel transmission routes in rural Tanzania National Institutes of Health 07 Jul 2010 30 Jun 2011
A Molecular Epidemiological Approach to Combating Footrot, an Endemic Disease of Sheep. BBSRC 01 Apr 2007 31 Mar 2011
Intra- and extra-cellular mechanisms affecting the persistence of Mycobacterium bovis in the environment: towards molecular surveillance of bovine TB. BBSRC 01 May 2007 30 Apr 2010
The impact of pollution on the evolution of antibiotic resistance in rhizobacteria. NERC 01 Jan 2007 31 Dec 2009
ASEM-DUO Fellowship Commission on Higher Education, Ministry of Education Thailand 04 Dec 2009 11 Dec 2009
CASE Studentship (Colette ONeill) Survival and dissemination of MRSA in the environment Lumora Limited 02 Oct 2006 01 Oct 2009
SE3231 - Validation and Epidemiological Application of Molecular Methods for Monitoring M Bovis Survival and Dissemination in the environment Department for Environment, Food and Rural Affairs 21 Jun 2007 20 Jun 2008
Evolution of disease: current patterns and future trends National Institutes of Health 01 Sep 2003 31 Aug 2007
Evolution of disease: current patterns and future trends National Institutes of Health 01 May 2003 01 May 2007
The Biology of Environmental Mycobacterium bovis, and its significance to the epidemiology of Bovine TB BBSRC 01 Feb 2004 31 Jan 2007
INDEX - STREP EU 01 Jan 2004 31 Dec 2006
Vacation Student Lumora Limited 19 Jun 2006 22 Sep 2006
A Multidisciplinary study of Salmonella-protozoa interactions on surfaces, liquid culture and soil:bacterial phenotype dynamics. BBSRC 16 Feb 2006 14 Aug 2006
Dissemination of Bacterial Genes (qc) Encoding Resistance to Quaternary Ammonium Compounds - CASE Award - Aileen Rahilly Wyeth 01 Oct 2002 30 Sep 2005
Real time PCR & high throughput sequencing facilities for biomedical research, microbiology and cell biology BBSRC 01 Oct 2003 30 Jun 2004
Rates and quantities of carbon flow through mycorrhizal mycelium to soil bacteria and fungal-feeders: Effects of micro-arthropod diversity NERC 01 Dec 2003 31 Mar 2004
Royal Society Conference Grant Royal Society 01 Dec 2003 31 Dec 2003