Research Interests
My current work aims to (i) investigate and model the function of gene networks underlying circadian oscillators and photoperiodic flowering, and (ii) decipher the regulatory logic within gene promoters that underlies specific temporal patterns of transcription.
Biography
As part of my PhD degree at Stony Brook University (New York)1992, I demonstrated the role of cyclic AMP in the circadian control of cell division in Euglena, a unicellular alga. Frustrated by the lack of genetics in this system, I chose during my post-doctoral training to work on Arabidopsis thaliana, then an emerging system for plant molecular genetics. As part of the NSF centre for Biological Timing at The University of Virginia, I studied the control of rhythmic transcription by the plant circadian clock. In 1996 I took up an independent position as a Warwick Research Fellow. My early work investigated the role of the circadian clock in the seasonal control of flowering, and led to the identification of some of the key components of the clock mechanism. This led to a lectureship in 2002 and an associate professorship in 2005.
- 'Achom, Mingkee, 'Roy, Proyash, 'Lagunas, Beatriz, 'Picot, Emma, 'Richards, L., 'Bonyadi-Pour, Roxanna, 'Pardal , Alonso Javier, 'Baxter, Laura, 'Richmond, Bethany L., 'Aschauer, N., 'Fletcher, E., 'Rowson, M., 'Blackwell, J., 'Rich-Griffin, C., 'Mysore, K. S., 'Wen, J., 'Ott, Sascha, 'Carr?, Isabelle A., 'Gifford, Miriam L., 2022. 'Plant circadian clock control of Medicago truncatula nodulation via regulation of Nodule Cysteine-Rich peptides. Journal of Experimental Botany, 73 (5), pp. 2142-2156
- Martí Ruiz, María Carmen, Hubbard, Katharine E., Gardner, Michael J., Jung, Hyun Ju, Aubry, Sylvain, Hotta, Carlos T., Mohd-Noh, Nur Izzati, Robertson, Fiona C., Hearn, Timothy J., Tsai, Yu-Chang, Dodd, Antony N., Hannah, Matthew, Carré, Isabelle A., Davies, Julia M., Braam, Janet, Webb, Alex A. R., 2018. Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock. Nature Plants, 4 (9), pp. 690-698
- Adams, Sally, Grundy, Jack, Veflingstad, Siren R., Dyer, Nigel, Hannah, Matthew, Ott, Sascha, Carré, Isabelle A., 2018. Circadian control of abscisic acid biosynthesis and signalling pathways revealed by genome-wide analysis of LHY binding targets. New Phytologist, 220 (3), pp. 893-907
- Adams, Sally, Manfield, Ian, Stockley, Peter, Carré, Isabelle A., 2015. Revised morning loops of the Arabidopsis circadian clock based on analyses of direct regulatory interactions. PLoS One, 10 (12)
- Grundy, Jack, Stoker, Claire, Carré, Isabelle A., 2015. Circadian regulation of abiotic stress tolerance in plants. Frontiers in Plant Science, 6
- Lozano, Jean-Claude, Schatt, Philippe, Botebol, Hugo, Verge, Valerie, Lesuisse, Emmanuel, Blain, Stephane, Carré, Isabelle A., Bouget, Francois-Yves, 2014. Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus. Plant Journal, 78 (6), pp. 1073-1083
- Blanc-Mathieu, Romain, Verhelst, Bram, Derelle, Evelyne, Rombauts, Stephane, Bouget, François-Yves, Carré, Isabelle A., Château, Annie, Eyre-Walker, Adam, Grimsley, Nigel, Moreau, Hervé, Piégu, Benoit, Rivals, Eric, Schackwitz, Wendy, Peer, Yves van de, Piganeau, Gwenaël, 2014. An improved genome of the model marine alga Ostreococcus tauri unfolds by assessing Illumina de novo assemblies. BMC Genomics, 15, pp. 1-11
- Carré, Isabelle A., Veflingstad, Siren R., 2013. Emerging design principles in the Arabidopsis circadian clock. Seminars in Cell & Developmental Biology, 24 (5), pp. 393-398
- Adams, Sally, Carré, Isabelle A., 2011. Downstream of the plant circadian clock : output pathways for the control of physiology and development. Essays in Biochemistry, Vol.49, pp. 53-69
- Picot, Emma, Krusche, Peter, Tiskin, Alexander, Carré, Isabelle A., Ott, Sascha, 2010. Evolutionary analysis of regulatory sequences (EARS) in plants. Plant Journal, Vol.64 (No.1), pp. 165-176
- Spensley, Mark, Kim, Jae-Yean, Picot, Emma, Reid, John, Ott, Sascha, Helliwell, Chris, Carré, Isabelle A., 2009. Evolutionarily conserved regulatory motifs in the promoter of the Arabidopsis clock gene LATE ELONGATED HYPOCOTYL. Plant Cell, Vol.21 (No.9), pp. 2606-2623
- Salazar, Jose Domingo, Saithong, Treenut, Brown, Paul E., Foreman, Julia, Locke, James C. W., Halliday, Karen J., Carré, Isabelle A., Rand, D. A. (David A.), Millar, A. J. (Andrew J.), 2009. Prediction of photoperiodic regulators from quantitative gene circuit models. Cell, Vol.139 (No.6), pp. 1170-1179
- Akman, Ozgur E., Locke, James C. W., Tang, Sanyi, Carré, Isabelle A., Millar, A. J. (Andrew J.), Rand, D. A. (David A.), 2008. Isoform switching facilitates period control in the Neurospora crassa circadian clock. Molecular Systems Biology, 4
- Pouteau, Sylvie, Carré, Isabelle A., Gaudin, Valerie, Ferret, Valerie, Lefebvre, Delphine, Wilson, Melanie, 2008. Diversification of photoperiodic response patterns in a collection of early-flowering mutants of arabidopsis. Plant Physiology, 148 (3), pp. 1465-1473
- Morris, Karl, Holmes, James, Codrai, Lesley, Huttly, Alison, Carré, Isabelle A., Jackson, Stephen D., 2003. Regulator of constans (roco), a novel component of the photoperiodic flowering pathway. Flowering Newsletter, pp. 43-46
- Pettya, Lisa M., Harberdb, Nicholas P., Carré, Isabelle A., Thomas, Brian, Jackson, Stephen D., 2003. Expression of the Arabidopsis gai gene under its own promoter causes a reduction in plant height in chrysanthemum by attenuation of the gibberellin response. Plant Science, 164 (2), pp. 175-182
- Thomas, Brian, Carré, Isabelle A., Jackson, Stephen D., 2006. Photoperiodism and flowering. Jordan, B. (ed.), The Molecular Biology and Biotechnology of Flowering, CAB International
- Carré, Isabelle A., Spensley, Mark, Kim, J., 2008. Dual oscillator control of LHY transcription in Arabidopsis. Annual Meeting of the Society-for-Experimental-Biology, Marseille, France, Jul 06-10, 2008, Published in Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, pp. S152-S152
| Title | Funder | Award start | Award end |
|---|---|---|---|
| An N-fix in time (Responsive Mode) | BBSRC | 01 Jun 2020 | 30 Nov 2023 |
| UK-Brazil International Partnering Award: Development of novel strategies to address plant-microbes interactions in planta | BBSRC | 01 Apr 2022 | 31 Mar 2023 |
| Keeping time for better nitrogen fixation MLSRF application for Emma Picot | Medical and Life Sciences Research Fund | 01 May 2021 | 30 Apr 2022 |
| Access agreement at Observatoire Oceanologique de Banyuls-sur-Mer | Sorbonne Universite | 02 Apr 2019 | 26 Apr 2019 |
| International Exchanges Scheme - Cost Share Programme (China) - GABA-regulation of circadian rhythms in Arabidopsis | Royal Society | 01 Jun 2014 | 31 Oct 2016 |
| Biosciences KTN Studentship - Control of environmental stress responses by the circadian clock and abscisic acid | Bayer Crop Science | 01 Oct 2012 | 30 Jun 2015 |
| Global control of rythmic gene expression by transcription factor LHY | BBSRC | 01 Jun 2008 | 31 May 2012 |
| A Novel, membrane-bound regulator of circadian rhythms in plant cells | Genetics Society | 04 Jul 2011 | 11 Sep 2011 |
| Probing the transcriptional network underlying circadian rhythms in Ostreococcus | BBSRC | 01 Oct 2009 | 31 May 2010 |
| Genetics Society Summer Studentship for Harriet Hurdle. | Genetics Society | 26 Jun 2006 | 25 Aug 2006 |
| Conference Grant - Biannual meeting of the Society for Research on Biological Rhythms. | Royal Society | 22 Jun 2004 | 27 Jun 2004 |
| Automated Luciferase Imaging | Royal Society | 01 May 2003 | 30 Apr 2004 |