Skip to main content Skip to navigation

Professor Kevin Moffat

Job Title
Professor
Department
Life Sciences
Phone
76524591
Research Interests

Tauopathies such as Alzheimer's Disease are one of the most serious diseases facing our ageing population. We are utilising the powerful genetic abilities of the fruitfly, Drosophila, to model tauopathies and discover novel genetic and pharmacological intervention strategies to ameliorate tau mediated neuronal death.
We have a long standing interest also in how identified neural networks are formed within the complexities of a large nervous system. To do this we are using , Drosophila, to study an amenable neural network, the giant fibre system.
The giant fibre system mediates the light-off escape reflex in the fly. (see Buzz)

We have developed enhancer-trap markers to follow the development of this neural network through embryogenesis, larval and pupal life.

In addition we use expression systems to disrupt the neural network and ask the physiological consequences of such manipulations in vivo.

We are currently interested in studying the function of a number of genes we have isolated that are expressed within the circuit.

Biography

B.Sc (Hons) Physiology and Biochemistry 1982 University of Reading
Ph.D. Bacterial Genetics 1986 Cranfield University

  • Moffat, Kevin G., 2008. Drosophila genetics for the analysis of neurobiological disease.. In Drosophila: a toolbox for the study of neurodegenerative disease, New York; Abingdon, Taylor & Francis Group, pp. 9-24
  • Moffat, Kevin G., Patel, S., Hultén, Maj A., 2009. Trisomy21, Down Syndrome and the origin of Alzheimer's disease. British Human Genetics Conference, University of Warwick, England, Aug 31 - Sep 02 2009, Published in Journal of Medical Genetics, pp. S22-S22
  • De, Antara, Baines, Richard A., Moffat, Kevin G., 2006. Pumilio: Role in regulation of neuronal excitability in Drosophila. JOURNAL OF NEUROGENETICS, pp. 109-110
  • Muraro, Nara I., Weston, Andrew, De, Antara, Moffat, Kevin G., Baines, Richard A., 2006. Role of Pumilio, nanos, and brain tumor in the regulation of the sodium channel encoded by paralytic. JOURNAL OF NEUROGENETICS, pp. 183-184
  • Wright, Duncan E., Moffat, Kevin G., Baines, Richard A., 2006. The impact of alternative splicing on the properties of the paralytic voltage-gated sodium channel. JOURNAL OF NEUROGENETICS, pp. 261-262
  • Caudron, Q., Lyn-Adams, Ceri Louise, Aston, John A. D., Frenguelli, Bruno G., Moffat, Kevin G., 2010. Quantitative assessment of ommatidial distortion in Drosophila melanogaster : a tool to investigate genetic interactions. Journal of Neurogenetics, Informa Healthcare
  • Lyn-Adams, Ceri Louise, Frenguelli, Bruno G., Moffat, Kevin G., Sutherland, Calum, 2010. Regulation of tau-dependent toxicity by brain selective/SAD kinases. Journal of Neurogenetics, Informa Healthcare
Title Funder Award start Award end
Alzheimers Research UK Summer Studentship - Sophie Crighton Aston University 01 Jul 2013 09 Aug 2013
Drosophila melanogaster as a model for Alzheimers Disease MRC 01 Feb 2010 31 Jan 2013
Investigating the Role of Drosophilia Ubiquitin Ligases in Alternative Splicing Royal Society 01 Oct 2010 30 Sep 2012
Alzheimers Research Trust 2007 Studentship for Ceri Louise Lynn-Adams Alzheimers Research UK 01 Oct 2007 30 Sep 2010
Cellular Intoxication by Ricin Department of Health 01 Jan 2005 31 Dec 2007
The role of Torp4a in protection from Oxideative Neurodegeneration Nuffield Foundation 18 Jul 2005 09 Sep 2005