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Molecular & Cellular Mechanisms of Phage Therapy

Phage therapy is the use of bacteriophages for therapeutic purposes. Bacteriophages are viruses that infect bacteria with high specificity. Phage therapy was introduced in the early 1900s, but nowadays, with the increase of bacterial resistance to antibiotics, phage therapy has proven to be of great importance and a potential alternative to antibiotics, not only in the field of medicine, but also in veterinary science and agriculture. In our lab, we are interested in understanding the underlying cellular and molecular mechanisms of phage therapy inside human cells infected with different pathogens of interest, and we also aim to engineer recombinant bacteriophages with improved properties to be used for future therapy or as rapid diagnostics for bacterial infections. For our research, we use human cell culture and human cell biology methods, microbiology, biochemistry, molecular & synthetic biology and advanced microscopy.

Current group members: 

Antonia Sagona Dr Antonia Sagona, Group Leader Gurneet Dhanoa

Gurneet Dhanoa, PhD student

Christian Moller-Olsen Christian Moller-Olsen, PhD student Kathyn Styles Dr Kathryn Styles, Post-doctoral
Research Fellow
Joshua Williams Joshua Williams, PhD student

Nathan Burton, PhD student
Maria Czajkowska

Maria Czajkowska, MBio student

Jaimee Kerven, MBio student

Ellie Dorsman, MBio student

Inbar Kushnir, MBio student
Wheatley

Joseph Wheatley, PhD student

Joseph is based in Engineering and Antonia is his second supervisor

Sahan Bandara

Sahan Liyanagedera, PhD student

Sahan is based in Engineering and Antonia is his second supervisor

Previous group members:

Richard Amaee

Aristotelis Charmpas

Gabrielle Christie

Stanley Ho

Giz Ibanoglu

Helen Jones

Lucy Kelly

Laurence Legon

Lindo Nyathi

Jess Oliver

Yanahan Paramalingam

Toby Ross

Christina Sheers

Martina Smith

Sophie Smith

Agata Stawicka

Jack Taylor

Matthew Wan

Katherine Winfield

Helen Wrigley

Anna Liuzzi

Ying Tang

Alex Moore

Hannah Vernon-Browne

Sagona lab news

Antimicrobial surfaces applications

New publication in Sagona lab, funded by BBSRC Future Leader Fellowship

New publication in Sagona lab in collaboration with the University of Loughborough: https://www.mdpi.com/1999-4923/11/9/475

New publication in Sagona lab funded by Newton British Council award: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235909/

New publication in Sagona lab funded by BBSRC Future Leader Fellowship: https://www.nature.com/articles/s41598-020-65867-4