· A hallmark of Parkinson's disease is the degeneration of a group of neurons in the brain that release the neurotransmitter dopamine (dopaminergic neurons). By introducing low concentrations of structurally-defined aggregates of alpha synuclein, a key toxic species in Parkinson’s disease, into single dopaminergic neurons, researchers from the University of Warwick have shown these protein aggregates open a specific channel in the cell membrane, reducing neuronal excitability. Furthermore they’ve shown that this can be partially prevented by pre-application of the commonly used anti-diabetic drug, glibenclamide.
Naturally occurring compounds in ash leaves could be linked to susceptibility of individual trees to the fungal disease ash dieback (ADB). But selecting trees with lower levels of these compounds and breeding for resistance could leave the UK ash tree population open to attack from invading insect pests in the future, according to scientists at the University of Warwick.
An International group of researchers, including the University of Warwick, have developed a new process to harness multiple disease models for outbreak management, meaning public health agency can understand the merits of different management options in testing times such as these currently experienced with Covid-19.
Infectious diseases could be detected, prevented and controlled thanks to a new £4m grant from the NIHR to the University of Warwick. Researchers will work with partners to develop the use of cutting edge genomics to protect public health.
The tropical disease Leishmaniasis is being tackled by catching female sand flies who carry the parasite that causes the disease.
There are now plans to commercialise the research which involves using male pheromones to attract female sand flies towards insecticide-treated areas.