Students interested in studying novel strategies to improve recovery after brain injury are particularly welcome to apply. Please see this recent review for more details of the exciting and innovative approach to brain injury that we have developed.
Funded PhD Project
Developing novel purine-based compounds to treat pain (in collaboration with Neurosolutions)
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Pain is a common condition that can be extremely debilitating for chronic sufferers. While a wide range of analgesics (compounds that provide pain relief) are available, not all analgesics are suitable for all types of pain and opioid analgesics can cause dependence. New analgesics are therefore needed.
Adenosine is a neurotransmitter in the central and peripheral nervous systems that has analgesic properties. In collaboration with leading pain specialists at Neurosolutions Ltd and colleagues at the Universities of Bern (Switzerland) and Cambridge (UK) this project will explore novel compounds targeting adenosine receptors for their potential as new classes of analgesics.
Through this project the successful student will gain excellent academic, technical and transferable skills in neuroscience, pain physiology and pharmaceutical drug discovery.
This Industrial Collaborative Awards in Science and Engineering (iCASE) studentship is offered by the MRC Funded Doctoral Training Partnership (DTP) in Interdisciplinary Biomedical Research. The successful candidate will be part of the DTP community throughout the four years of study.
Other PhD Projects in the Frenguelli & collaborator labs at Warwick:
- Helping the brain help itself: the purine salvage pathway and the restoration of ATP in neurones and glial cells after brain injury
- Novel pharmacological approaches to the control of neural circuits
- Molecular mechanisms of cellular and behavioural adaptations to environmental enrichment in mammals
- Regulation of circadian behaviour by MSK1