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Marine microbiology

Research Leader: Professor David Scanlan

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A major research theme in the group is to use molecular biological techniques to assess the genotype and nutrient status of marine photosynthetic microbes so that the specific factors controlling marine photosynthesis in single cells can be identified. In addition, we are using molecular genetic tools and molecular ecological approaches to investigate the way these organisms perceive and adapt to changes in their environment, and particularly how certain strains have adapted to occupy a specific niche. Thus, we are using fine-scale genetic markers and high throughput sequencing to assess the community structure of photosynthetic microbes over large spatial scales, and coupling this with meta-‘omic approaches to decipher the functional potential and in situ activity of these organisms. We focus on both the role of abiotic (light, nutrients) and biotic (virus infection, protistan grazing) factors in controlling the abundance of these organisms. Moreover, functional identification of genes implicated as playing a specific role in the adaptation of marine (and freshwater) cyanobacteria to their environment is being pursued by mutant construction and analysis. This latter work is being greatly aided by the recent completion of various Prochlorococcus and marine Synechococcus genomes see http://abims.sb-roscoff.fr/cyanorak/. This is paving the way for detailed comparative genomic (transcriptomic and proteomic) analyses in these organisms and the viruses that infect them.

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Work focuses on the following key groups of picophotoautotrophs, organisms which are widespread and abundant in marine ecosystems, and contribute significantly to global primary production. Hence, these are environmentally relevant organisms and all contain cultured counterparts. The cyanobacterial component are also capable of growth at a wide range of irradiance and in waters with low or undetectable levels of inorganic nutrients:

  • Prochlorococcus
  • Synechococcus
  • Picoeukaryotes

Other recent research avenues in the Scanlan lab include projects on i) marine heterotrophic bacterioplankton, particularly focusing on lipid remodeling, degradation of N osmolytes, and phototroph-heterotroph interactions and ii) P acquisition mechanisms in the plant-rhizosphere.

 

Current Group Members

Dr Rich Puxty (Postdoctoral research assistant), Dr Branko Rihtman (Postdoctoral Research Assistant), Dr Michaela Mausz (Postdoctoral research assistant), Dr Richard Guilloneau (Postdoctoral research assistant), Slawek Michniewski (Final Year PhD student), Betty Sands (Final Year PhD student), Rebekah Jones (Final Year PhD student), Linda Westermann (3rd year PhD student), Alberto Torcello (2nd Year PhD student), Holly Shropshire (2nd Year PhD student), Rachel Stirrup (2nd Year PhD student) and Julie Scanlan (Research Technician).

People and projects

Dr Rich Puxty, Postdoctoral researcher

We have recently shown that viruses of abundant marine cyanobacteria shut down CO2 fixation during infection. Rich’s project builds on this, focusing on assessing how marine Synechococcus CO2 fixation varies during cyanophage infection under a range of environmental conditions, particularly under conditions of host nutrient limitation. The project also aims to provide a mechanistic understanding of the process.

Dr Branko Rihtman, Postdoctoral Researcher

Branko Rihtman Postdoctoral Research Fellow Branko’s research focuses on an ERC funded EcoLipid project with PI Dr Yin Chen.

Dr Michaela Mausz, Postdoctoral Researcher

michaelamausz.jpgMichaela’s research focuses on an ERC funded EcoLipid project with PI Dr Yin Chen.

Dr Richard Guilloneau, Postdoctoral Researcher

Richard Guilloneau Postdoctoral ResearcherRichard’s research focuses on an ERC funded EcoLipid project with PI Dr Yin Chen.

 
Sands_Photo_Jul17Betty Sands, Final Year PhD student

Funded through the NERC CENTA DTP and supervised by Dr Isabelle Carré and Prof Dave Scanlan, Betty’s project is investigating the genetics and physiological consequences of light quality responses in Ostreococcus, a eukaryotic picophytoplankton abundant in the coastal ocean. Surface and deep ecotypes of Ostreococcus are being compared and the role light quality plays in adaptation to these specific niches assessed.

jones_photo_jul17.jpgRebekah Jones, Final Year PhD student

Rebekah is investigating the role of lipid remodelling in pathogenic bacteria and the implications of this for antimicrobial resistance and host-pathogen interactions. Rebekah is supervised by Dr Yin Chen and Prof Dave Scanlan and funded by the Medical Research Council Interdisciplinary Biomedical Research doctoral training programme.

Holly ShropshireHolly Shropshire, 2nd Year PhD Student

Holly is supervised by Dr Yin Chen and Professor Dave Scanlan investigating the role of lipid remodelling in pathogenic bacteria of the genera Burkholderia.

Stirrup_PhotoRachel Stirrup, 2nd Year PhD Student

Rachel's research focuses on an ERC funded EcoLipid project with PI Dr Yin Chen.

Alberto TorcelloAlberto Torcello, 2nd Year PhD Student

Alberto's PhD project focuses on investigating the function of known 'unknown' genes in marine cyanobacteria.

Research Facilities

Excellent cyanobacterial and eukaryotic phytoplankton culturing facilities including walk-in temperature controlled growth rooms, supported by department-run media preparation service.

In House MiSeq sequencing and real-time qPCR facilities, high-speed BD Influx flow cytometric sorting capacity, LC-MS facility for metabolite detection, state-of-the-art proteomics facility, and within lab access to molecular biology, biochemistry, analytical flow cytometry and photophysiological (PhytoPAM, light array) facilities.

Collaborators

Dr Gary Bending (University of Warwick, SLS) Phosphorus acquisition in the soil plant-rhizosphere

Dr Claudia Blindauer (University of Warwick, Chemistry) Marine cyanobacterial metalloproteomics

Dr Yin Chen (University of Warwick, SLS) Marine heterotroph phospholipid recycling and N osmolyte degradation

Dr Martha Clokie (University of Leicester, UK) Marine cyanophage

Dr Christophe Corre (University of Warwick, SLS/Chemistry) Structure and function of cyanobacterial metabolites

Dr Laurence Garczarek (Station Biologique, Roscoff, France) Prochlorococcus and Synechococcus molecular ecology and genomics

Dr Mikal Heldal (University of Bergen, Norway) Elemental composition of marine picocyanobacteria

Prof Wolfgang Hess (University of Freiburg, Germany) Marine picocyanobacteria genomics and small RNAs

Dr Wei Huang (University of Oxford) Raman spectroscopy

Dr Martin Ostrowski (Macquarie University, Sydney) Synechococcus metagenomics/biodiversity

Dr Frederic Partensky (Station Biologique, Roscoff, France) Prochlorococcus and Synechococcus molecular ecology and genomics

Prof Anton Post (Florida Atlantic University, USA) Prochlorococcus and Synechococcus molecular ecology and genomics

Dr Christophe Six (Station Biologique, Roscoff, France) Marine cyanobacterial lipids

Prof Paul Taylor University of Leeds - The Evolutionary Origins of Chemical Messengers in Humans

Dr Osvaldo Ulloa (Universidad de Concepción, Chile) Prochlorococcus and Synechococcus community structure in oxygen minimum zones

Dr Daniel Vaulot (Station Biologique, Roscoff, France) Picoeukaryote biodiversity and genomics

Prof Liz Wellington (University of Warwick, SLS) Metaproteomics of phosphorus acquisition in the soil plant-rhizosphere

Dr Mike Zubkov (Scottish Association for Marine Sciences, Oban, Scotland) Flow sorting of photosynthetic microbes/Mixotrophy/Grazing/P acquisition.

 

Prospective Students and postdoctoral researchers

Students interested in pursuing graduate research with Prof. Scanlan are encouraged to contact him directly by email (d.j.scanlan@warwick.ac.uk). For more information about graduate programs at the University of Warwick see http://www2.warwick.ac.uk/fac/sci/lifesci/study/pgr/research/phd

Prospective postdoctoral researchers with interests in the field of marine microbiology, particularly photosynthetic microorganisms are encouraged to contact Prof. Scanlan directly by email (address above) to discuss potential research projects and funding opportunities.