| Title | Funder | Award start | Award end |
|---|---|---|---|
| Conditions of use agreement with University of Tubingen for bacterial strain | Universitat Tübingen | 01 Jul 2021 | 30 Jun 2024 |
| SIMBA: signal Propagation and Information in Microscale Biological Applications | EPSRC | 01 May 2021 | 31 Oct 2023 |
| BBSRC Mid-range Equipment ALERT 2021 Application - November 2021 | BBSRC | 01 Aug 2022 | 31 Jul 2023 |
| Terahertz skinometer for improved cancer prevention and treatment | EPSRC | 01 Apr 2019 | 31 Dec 2022 |
| Early Career Fellowship costed extension for Dr Fabrizio Alberti (linked to Ideate 58035 Engineering a yeast cell factory for production of valuable meroterpenoids) | Leverhulme Trust | 01 Nov 2021 | 31 Jan 2022 |
| Combatting Antimicrobial Resistance Training Network | European Commission | 01 Jan 2018 | 31 Dec 2021 |
| Developing a Cell Free Transcription-Translation Engineering Platform for Natural Product Research. iCASE studentship with Syngenta under Synbio CDT | Syngenta Ltd | 25 Nov 2018 | 24 Nov 2021 |
| Engineering a yeast cell factory for production of valuable meroterpenoids. Early Career Fellowship for Dr Fabrizio Alberti | Leverhulme Trust | 01 Nov 2018 | 31 Oct 2021 |
| 19 Alert mid-range Equipment Initiative: equipment to upgrade the 600 NMR console at the NMR facility. | BBSRC | 01 Nov 2020 | 31 Mar 2021 |
| Warwick Integrative Synthetic Biology Centre (WISB) | BBSRC | 14 Nov 2014 | 31 May 2020 |
| Novel inducible gene expression systems based on furan inducers and the MmfR transcriptional rerpessor | BBSRC | 01 Jun 2015 | 30 Apr 2019 |
| Genome mining of marine bacteria for novel bioactive natural products 2016 China NSFC Costshare | Royal Society | 01 Mar 2017 | 30 Mar 2019 |
| 16ALERT: Mid-Range Equipment Initiative: A high sensitivity triple quadruple mass spectrometer coupled to an ultra-high pressure liquid chromatograph system for quantitative analysis | BBSRC | 01 Jul 2017 | 30 Jun 2018 |
| Discovery of antimicrobials active against Clostridium difficile from actinomycete gene clusters. MLSRF bursary for Dr Fabrizio Alberti | Medical and Life Sciences Research Fund | 01 Jun 2017 | 30 Nov 2017 |
| Developing World Scholarship for Attah Francis Alfred Unuagbe: Characterising and exploiting putative antimicrobial cyclotides from Rinorea dentata used in Nigerian ethnomedicine | Royal Society of Chemistry | 01 Oct 2016 | 31 Dec 2016 |
| Characterising and exploiting cyclotides from Nigerian ethnomedicinal plants | EPSRC | 01 Aug 2016 | 01 Dec 2016 |
| Establishing the potential of biosynthetic urea-synthetases as industrial biocatalysts | BBSRC | 01 May 2016 | 31 Oct 2016 |
| Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics | BBSRC | 01 Sep 2013 | 30 Sep 2016 |
| New Chemical Keys to unlock microbial antibiotics- University Research Fellowship (supplement) | Royal Society | 10 Apr 2014 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- URF (Supplemental) | Royal Society | 22 Feb 2013 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- URF (Supplemental) | Royal Society | 25 Jan 2012 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- University Research Fellowship | Royal Society | 01 Oct 2010 | 30 Sep 2015 |
| New Chemical Keys to unlock microbial antibiotics- University Research Fellowship | Royal Society | 01 Oct 2010 | 30 Sep 2015 |
| Co-crystallisation of transcriptional repressors and synthetic oligonucleotides | Royal Society | 01 Apr 2012 | 31 Mar 2014 |
| New Chemical Keys to unlock microbial antibiotics- URF (Supplemental) | Royal Society | 21 Nov 2011 | 30 Sep 2012 |
| International travel grant- Chemistry and Health | Royal Society | 04 Jun 2011 | 10 Jun 2011 |
| Elucidation of the Unusual Methylenomycin Biosynthetic Pathway in Streptomyces Coelicolor. | BBSRC | 01 Jul 2006 | 30 Jun 2009 |
Professor Christophe Corre
Professor
Email: c.corre@warwick.ac.uk
Phone: 024 765 23557
Office: D026Link opens in a new window
Twitter: @CorreLabo
Corre lab
Research Clusters
Quantitative, Systems & Engineering Biology
Warwick Centres and GRPs
Warwick Integrative Synthetic Biology Centre (WISB)
Warwick Antimicrobial Interdisciplinary Centre (WAMIC)
Warwick Environmental Systems Interdisciplinary Centre (WESIC)
Vacancies and Opportunities
For PhD and postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.
Research Interests
Bacterial natural products are our main subject of investigation.
We particularly interested in understanding and exploiting the regulatory mechanisms that control the production of bioactive molecules (e.g. antibiotics, agrochemicals, sunscreen agent) in actinobacteria. Our work is at the interface of chemistry and biology, it focuses on three directly related research themes:
- Bacterial Transcriptional Regulators: We investigate the molecular mechanisms by which bacteria control the biosynthesis of natural products. With this aim in mind, we characterise (in vivo and in vitro) and exploit different families of transcription factors that regulate the expression of gene clusters that direct the assembly of these natural products.
- Bioactive Natural Products: Our detailed understanding of such regulatory systems then opens the way to the discovery of new bioactive natural products from gene clusters which are typically silent in the laboratory environment. Indeed, we have been able to rationally inactivate specific transcriptional repressor genes and/or overexpress transcriptional activators to discover novel antibiotic-like molecules.
- Biocatalysts: The structural diversity of such natural products relies on the activity of specialised/unique sets of enzymes able to assemble these complex structures. These proteins can be developed and exploited as biocatalysts for the manufacture of high value chemicals.
Research: Technical Summary
- Professor, University of Warwick (2023 - present)
- Reader, University of Warwick (2021 - 2023)
- Associate Professor, University of Warwick (2015 - 2021)
- Assistant Professor, University of Warwick (2013 - 2015)
- Royal Society, University Research Fellowship (2010 - 2016)
- Wellcome Trust, Value in People Research Fellowship (2009-2010)
- Postdoctoral Researcher, University of Warwick (2004-2009)
- PhD student in Chemical Biology, University of Exeter (2000 - 2004)
Weaver, Jack A., Alkhder, Duha, Prasongpholchai, Panward, Tadesse, Michaël D., de los Santos, Emmanuel L. C., Song, Lijiang, Corre, Christophe and Alberti, Fabrizio (2024) Early steps of the biosynthesis of the anticancer antibiotic pleurotin. ACS Chemical Biology, 19 (11). pp. 2284-2290. doi:10.1021/acschembio.4c00599 ISSN 1554-8929.
Prasongpholchai, Panward, Tucker Harvey, Sam, Burgess, Charles, Jenkins, Robert, Wilkening, Ina, Corre, Christophe, Song, Lijiang and Tosin, Manuela (2024) Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus. Chemical Communications . doi:10.1039/D4CC04963B ISSN 1359-7345. (In Press)
Hymas, Michael, Wongwas, Sopida, Roshan, Simin, Whittock, Abigail L., Corre, Christophe, Omidyan, Reza and Stavros, Vasilios G. (2024) A multipronged bioengineering, spectroscopic and theoretical approach in unravelling the excited-state dynamics of the archetype mycosporine amino acid. The Journal of Physical Chemistry Letters, 15 . pp. 7424-7429. doi:10.1021/acs.jpclett.4c01254 ISSN 1948-7185.
Waschulin, Valentin, Borsetto, Chiara, Corre, Christophe and Wellington, Elizabeth M. H. (2023) Design and validation of a PCR screen for γ-butyrolactone-like regulatory systems in Streptomyces. Access Microbiology, 5 (9). doi:10.1099/acmi.0.000661.v3 ISSN 2516-8290.
Whittock, Abigail, Ding, Xuefei, Ramirez Barker, Xavier, Auckloo, Nazia, Sellers, Rebecca A., Woolley, Jack M., Tamareselvy, Krishnan, Vincendet, Marine, Corre, Christophe, Pickwell-MacPherson, Emma and Stavros, Vasilios G. (2023) Spectroscopic insight on impact of environment on natural photoprotectants. Chemical Science, 14 (24). pp. 6763-6769. doi:10.1039/d3sc01875j ISSN 2041-6539.
Huang, Chuan, Zabala, Daniel, de los Santos, Emmanuel, Song, Lijiang, Corre, Christophe, Alkhalaf, Lona M. and Challis, Gregory L. (2023) Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis. Nucleic Acids Research, 51 (3). pp. 1488-1499. doi:10.1093/nar/gkad009 ISSN 1362-4962.
Legon, Laurence, Corre, Christophe, Bates, Declan G. and Mannan, Ahmad A. (2022) gcFront : a tool for determining a Pareto front of growth-coupled cell factory designs. Bioinformatics, 38 (14). pp. 3657-3659. doi:10.1093/bioinformatics/btac376 ISSN 1460-2059.
Whittock, Abigail L., Woolley, Jack Matthew, Auckloo, Nazia, Corre, Christophe and Stavros, Vasilios G. (2022) Investigating the ultrafast dynamics and long-term photostability of an isomer pair, Usujirene and Palythene, from the Mycosporine-like amino acid family. Molecules, 27 (7). 2272. doi:10.3390/molecules27072272 ISSN 1420-3049.
Waschulin, Valentin, Borsetto, Chiara, James, Robert, Newsham, Kevin K., Donadio, Stefano, Corre, Christophe and Wellington, Elizabeth M. H. (2022) Biosynthetic potential of uncultured Antarctic soil bacteria revealed through long-read metagenomic sequencing. The ISME Journal, 16 . pp. 101-111. doi:10.1038/s41396-021-01052-3 ISSN 1751-7362.
Abiola, Temitope T., Auckloo, Nazia, Woolley, Jack Matthew, Corre, Christophe, Poigny, Stéphane and Stavros, Vasilios G. (2021) Unravelling the photoprotection properties of garden cress sprout extract. Molecules, 26 (24). e7631. doi:10.3390/molecules26247631 ISSN 1420-3049.
Whittock, Abigail L., Auckloo, Nazia, Cowden, Adam M., Turner, Matthew A. P., Woolley, Jack Matthew, Wills, Martin, Corre, Christophe and Stavros, Vasilios G. (2021) Exploring the blueprint of photoprotection in Mycosporine-like Amino Acids. The Journal of Physical Chemistry Letters, 12 (14). pp. 3641-3646. doi:10.1021/acs.jpclett.1c00728 ISSN 1948-7185.
Zhou, Shanshan, Bhukya, Hussain, Malet, Nicolas, Harrison, Peter J. , Rea, Dean, Belousoff, Matthew J., Venugopal, Hariprasad, Sydor, Paulina K., Styles, Kathryn, Song, Lijiang, Cryle, Max J., Alkhalaf, Lona M., Fülöp, Vilmos, Challis, Gregory L. and Corre, Christophe (2021) Molecular basis for control of antibiotic production by a bacterial hormone. Nature, 590 (7846). pp. 463-467. doi:10.1038/s41586-021-03195-x ISSN 0028-0836.
Moore, Simon J., Lai, Hung-En, Chee, Soo-Mei, Toh, Ming, Coode, Seth, Chengan, Kameshwari, Capel, Patrick, Corre, Christophe, de los Santos, Emmanuel L. C. and Freemont, Paul S. (2021) A streptomyces venezuelae cell-free toolkit for synthetic biology. ACS Synthetic Biology, 10 (2). pp. 402-411. doi:10.1021/acssynbio.0c00581 ISSN 2161-5063.
Chhun, Audam, Sousoni, Despoina, Aguilo-Ferretjans, Maria del Mar, Song, Lijiang, Corre, Christophe and Christie-Oleza, Joseph A. (2021) Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica. Microbial Biotechnology, 14 (1). pp. 291-306. doi:10.1111/1751-7915.13722 ISSN 1751-7907.
Zhou, Shanshan, Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2020) MmfL catalyses formation of a phosphorylated butenolide intermediate in methylenomycin furan biosynthesis. Chemical Communications, 56 (92). pp. 14443-14446. doi:10.1039/d0cc05658h ISSN 1364-548X.
Kaur, Divjot, Alkhder, Duha, Corre, Christophe and Alberti, Fabrizio (2020) Engineering isoprenoid quinone production in yeast. ACS Synthetic Biology, 9 (9). pp. 2239-2245. doi:10.1021/acssynbio.0c00081 ISSN 2161-5063.
Furner-Pardoe, Jessica, Anonye, Blessing O., Cain, Ricky, Moat, John, Ortori, Catherine A., Lee, Christina, Barrett, David A., Corre, Christophe and Harrison, Freya (2020) Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Scientific Reports, 10 (1). 12687. doi:10.1038/s41598-020-69273-8 ISSN 2045-2322.
Alberti, Fabrizio and Corre, Christophe (2019) Editing streptomycete genomes in the CRISPR/Cas9 age. Natural Product Reports, 36 (9). pp. 1237-1248. doi:10.1039/c8np00081f ISSN 0265-0568.
Alberti, Fabrizio, Leng, Daniel J., Wilkening, Ina, Song, Lijiang, Tosin, Manuela and Corre, Christophe (2019) Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery. Chemical Science, 10 (2). pp. 453-463. doi:10.1039/C8SC03814G ISSN 2041-6520.
Bowyer, Jack E., LC. de los Santos, Emmanuel, Styles, Kathryn, Fullwood, Alex, Corre, Christophe and Bates, Declan (2017) Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor. Journal of Biological Engineering, 11 (1). 30. doi:10.1186/s13036-017-0071-6 ISSN 1754-1611.
Li, Xiao, Wang, Juan, Shi, Mingxin, Wang, Weishan, Corre, Christophe and Yang, Keqian (2017) Evidence for the formation of ScbR/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. Applied Microbiology and Biotechnology, 101 (13). pp. 5333-5340. ISSN 0175-7598.
Wang, Weishan, Yang, Tongjian, Li, Yihong, Li, Shanshan, Yin, Shouliang, Styles, Kathryn, Corre, Christophe and Yang, Keqian (2016) Development of a synthetic oxytetracycline-inducible expression system for streptomycetes using de novo characterized genetic parts. ACS Synthetic Biology, 5 (7). pp. 765-773. doi:10.1021/acssynbio.6b00087 ISSN 2161-5063.
Sidda, John D., Poon, Vincent, Song, Lijiang, Wang, Weishan, Yang, Keqian and Corre, Christophe (2016) Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. Organic and Biomolecular Chemistry, 14 . pp. 6390-6393. doi:10.1039/c6ob00840b ISSN 1477-0520.
Sidda, John D., Song, Lijiang, Poon, Vincent, Al-Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2014) Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Science, Volume 5 . pp. 86-89. doi:10.1039/c3sc52536h ISSN 2041-6520.
Tang, Kunkun, Beccantini, Alberto and Corre, Christophe (2014) Combining discrete equations method and upwind downwind-controlled splitting for non-reacting and reacting two-fluid computations : one dimensional case. Computers & Fluids, 93 . pp. 74-90. doi:10.1016/j.compfluid.2014.01.017 ISSN 0045-7930.
Song, Lijiang, Laureti, Luisa, Corre, Christophe, Leblond, Pierre, Aigle, Bertrand and Challis, Gregory L. (2014) Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis. The Journal of Antibiotics, Volume 67 (Number 1). pp. 71-76. doi:10.1038/ja.2013.119 ISSN 0021-8820.
Sidda, John D., Song, Lijiang, Poon, Vincent, Al Bassam, Mahmoud, Lazos, Orestis, Buttner, Mark J., Challis, Gregory L. and Corre, Christophe (2013) Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chemical Sciences, 5 (1). pp. 86-89. doi:10.1039/C3SC52536H ISSN 2041-6539.
Corre, Christophe (2013) In search of the missing ligands for TetR family regulators. Chemistry & Biology, Volume 20 (Number 2). pp. 140-142. ISSN 1074-5521 doi:10.1016/j.chembiol.2013.02.005
Sidda, John D. and Corre, Christophe (2012) Gamma-butyrolactone and furan signaling systems in streptomyces. Methods in Enzymology, 517 . pp. 71-87. doi:10.1016/B978-0-12-404634-4.00004-8 ISSN 0076-6879.
Aigle, Bertrand and Corre, Christophe (2012) Waking up streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors. Methods in Enzymology, Vol.517 . pp. 343-366. doi:10.1016/B978-0-12-404634-4.00017-6 ISSN 0076-6879.
Song, Lijiang, Laureti, L., Gomez-Escribano, J. P., Fox, David J., Yeo, V., Corre, Christophe, Huang, S., Leblond, P., Aigle, B., Bibb, M. and Challis, Gregory L. (2012) Bacterial genome mining for novel natural product discovery. Planta Medica, Volume 78 (Number 11). Article number IL7. doi:10.1055/s-0032-1320194 ISSN 0032-0943.
Sydor, Paulina K., Barry, Sarah M., Odulate, Olanipekun M., Barona-Gomez, Francisco, Haynes, Stuart W., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Regio- and stereodivergent antibiotic oxidative carbocyclizations catalysed by Rieske oxygenase-like enzymes. Nature Chemistry, Vol.3 (No.5). pp. 388-392. doi:10.1038/nchem.1024 ISSN 1755-4330.
Laureti, L., Song, Lijiang, Huang, S., Corre, Christophe, Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proceedings of the National Academy of Sciences of the United States of America, Vol.108 (No.15). pp. 6258-6263. doi:10.1073/pnas.1019077108 ISSN 0027-8424.
Bunet, R., Song, Lijiang, Mendes, M. V., Corre, Christophe, Hotel, L., Rouhier, N., Framboisier, X., Leblond, Pierre, Challis, Gregory L. and Aigle, B. (2011) Characterization and manipulation of the pathway-specific late regulator AlpW reveals streptomyces ambofaciens as a new producer of kinamycins. Journal of Bacteriology, Vol.193 (No.5). pp. 1142-1153. doi:10.1128/JB.01269-10 ISSN 0021-9193.
Malet, Nicolas, Song, Lijiang, Corre, Christophe and Challis, Gregory L. (2011) Structure-activity relationship and biosynthesis of signaling molecules controlling methylenomycin antibiotic production in Streptomyces coelicolor. American Chemical Society. Abstracts of Papers (at the National Meeting), Vol.241 (No.142-BIOL ). ISSN 0065-7727
Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe, Song, Lijiang and Challis, Gregory L. (2011) Stereochemical elucidation of streptorubin B. Journal of the American Chemical Society, Vol.133 (No.6). pp. 1793-1798. doi:10.1021/ja109164t ISSN 0002-7863.
Haynes, Stuart W., Sydor, Paulina K., Corre, Christophe and Challis, Gregory L. (2011) Elucidation of pathways for antibiotic biosynthesis in streptomyces coelicolor A3(2). In: Wrigley, Stephen, (ed.) Functional Molecules from Natural Sources. Special publication (Royal Society of Chemistry (Great Britain)) (No.320). Cambridge: Royal Society of Chemistry, pp. 149-160. ISBN 9781847552594
Aigle, B., Bunet, R., Corre, Christophe, Garenaux, Amélie, Hotel, L., Huang, S., Laureti, L., Lautru, Sylvie, Mendes, V. M., Nezbedová, S., Nguyen, H., Song, Lijiang, Challis, Gregory L., Leblond, Pierre and Pernodet, Jean-Luc (2011) Genome-guided exploration of streptomyces ambofaciens secondary metabolism. In: Streptomyces : molecular biology and biotechnology. [Wymondham]: Caister Academic, pp. 179-194. ISBN 9781904455776
Corre, Christophe, Haynes, Stuart W., Malet, Nicolas, Song, Lijiang and Challis, Gregory L. (2011) A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically C-13-labelled glycerols. Chemical Communications, Vol.46 (No.23). pp. 4079-4081. doi:10.1039/c000496k ISSN 1359-7345.
Corre, Christophe and Challis, Gregory L. (2010) Exploiting genomics for new natural product discovery in prokaryotes. In: Mander, Lewis N. and Liu, Hung-wen, 1952-, (eds.) Comprehensive natural products II : chemistry and biology. Amsterdam ; Boston: Elsevier, pp. 429-453. ISBN 9780080453828
Corre, Christophe and Challis, Gregory L. (2009) New natural product biosynthetic chemistry discovered by genome mining. Natural Product Reports, Vol.26 (No.8). pp. 977-986. ISSN 0265-0568 doi:10.1039/b713024b
O'Rourke, S. (Sean), Wietzorrek, Andreas, Fowler, Kay, Corre, Christophe, Challis, Gregory L. and Chater, K. F. (2009) Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor. Molecular Microbiology, Vol.71 (No.3). pp. 763-778. doi:10.1111/j.1365-2958.2008.06560.x ISSN 0950-382X.
Chen, Kan, Rannulu, Nalaka S., Cai, Yang, Lane, P., Liebl, Andrea L., Rees, Bernard B., Corre, Christophe, Challis, Gregory L. and Cole, Richard B. (2008) Unusual odd-electron fragments from even-electron protonated prodiginine precursors using positive-ion electrospray tandem mass spectrometry. Journal of The American Society for Mass Spectrometry, Vol.19 (No.12). pp. 1856-1866. doi:10.1016/j.jasms.2008.08.002 ISSN 1044-0305.
Corre, Christophe, Song, Lijiang, O'Rourke, S. (Sean), Chater, K. F. and Challis, Gregory L. (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proceedings of the National Academy of Sciences of the United States of America, Vol.105 (No.45). pp. 17510-17515. doi:10.1073/pnas.0805530105 ISSN 0027-8424.
Mo, SangJoon, Sydor, Paulina K., Corre, Christophe, Alhamadsheh, Mamoun M., Stanley, Anna E., Haynes, Stuart W., Song, Lijiang, Reynolds, Kevin A. and Challis, Gregory L. (2008) Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology, Vol.15 (No.2). pp. 137-148. doi:10.1016/j.chembiol.2007.11.015 ISSN 1074-5521.
Corre, Christophe and Challis, Gregory L. (2007) Heavy tools for genome mining. Chemistry & Biology, Volume 14 (Number 1). pp. 7-9. ISSN 1074-5521 doi:10.1016/j.chembiol.2007.01.001
Song, Lijiang, Barona-Gomez, Francisco, Corre, Christophe, Xiang, Longkuan, Udwary, Daniel W., Austin, Michael B., Noel, Joseph P., Moore, Bradley S. and Challis, Gregory L. (2006) Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society, 128 (46). pp. 14754-14755. doi:10.1021/ja065247w ISSN 0002-7863.
Walton, Laura J., Corre, Christophe and Challis, Gregory L. (2006) Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites. In: Joint 8th Symposium on the Genetics and Molecular Biology of Industrial Microorganisms/8th International Conference on Biotechnology of Microbial Products, San Diego, USA, 14-18 Vov2004. Published in: Journal of Industrial Microbiology and Biotechnology, Volume 33 (Number 2). pp. 105-120. doi:10.1007/s10295-005-0026-7 ISSN 1367-5435.
Stanley, Anna E., Walton, Laura J., Zerikly, Malek Kourdi, Corre, Christophe and Challis, Gregory L. (2006) Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2 '-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chemical Communications (Number 38). pp. 3981-3983. doi:10.1039/b609556a ISSN 1359-7345.
Corre, Christophe and Challis, Gregory L. (2005) Evidence for the unusual condensation of a diketide with a pentulose in the methylenomycin biosynthetic pathway of Streptomyces coelicolor A3(2). Chembiochem, Volume 6 (Number 12). pp. 2166-2170. doi:10.1002/cbic.200500243 ISSN 1439-4227.
Chris is the Director of Postgraduate Research in the School of Life Sciences. He teaches on the following modules: Beyond Science: Collaborative Student-Led Challenges (CH169); Enzymology (LF208); Tools for Biochemical Discovery Laboratories (LF219); Advanced Chemical Biology (CH411).
I am happy to receive enquiries about Research projects in my group (at undergraduate, postgraduate or postdoctoral level), please contact me at the above email address.
Y3 UG projects are available to students who want to work in the field of bacterial natural products (e.g. antibiotics, agrochemicals, sunscreen agents), encompassing microbiology and analytical chemistry.