Please read our student and staff community guidance on COVID-19
Skip to main content Skip to navigation

Dr Phill Stansfeld

Job Title
Associate Professor
Department
Chemistry
Phone
02476523864
Web Link
Research Interests

Associate Professor in both School of Life Sciences and Department of Chemistry

One of the fundamental challenges in biological sciences is to visualise biomolecular machines in high-resolution detail. This is notoriously difficult, expensive and time-consuming to achieve by using experimental techniques, especially for proteins that exist in cell membranes, known as Integral membrane proteins (IMPs). These proteins play fundamental roles in cell biology e.g. as processing enzymes, ion channels, drug receptors, and solute transporters.

My group uses computational methods to study IMP structures and currently hosts MemProtMD; a pipeline for inserting experimentally-solved IMP structures into their native bilayer environment and analysing the stability, dynamics and resultant lipid interactions. This resource uses multiscale molecular dynamics (MD) simulations that permit the accurate assembly of an IMP into a membrane at the coarse-grain level, prior to careful assessment of the quality of the IMP structure at atomic resolution.

The MemProtMD pipeline also forms a springboard to studying the dynamics of experimentally solved structures through MD simulations. With the increasing threat of anti-microbial resistance, we are especially interested in bacterial IMPs. Knowledge of the three-dimensional structures of proteins involved in essential processes provides the physical details of potentially viable targets for killing drug-resistant, pathogenic bacteria. By breathing life into these frozen structures we may assess the association of proteins with lipids, drug molecules and other components of the protein complexes.

Biography

2003 Bsc with Hons (1st Class) Biological Sciences, University of Edinburgh
2007 PhD Biochemistry, University of Leicester
2007-2010 Wellcome Trust Postdoc, University of Oxford
2011-2014 BBSRC Researcher Co-Investigator, University of Oxford
2015-2019 Research Fellow, University of Oxford
2019- Associate Professor (Reader) Computational Biochemistry, University of Warwick

Title Funder Award start Award end
Grant Transfer Phill Stansfeld 'The Lipoprotein Biogenesis Pathway: An emerging Structural Target for Novel Antibiotics' BB/P01948/1 BBSRC 30 Sep 2019 07 Jan 2021

Research Themes:

Group Website: