Events
Tuesday, May 28, 2019
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Wellcome VisitWarwick Medical SchoolOn 28th May Wellcome will be visiting Warwick to hear from some of our researchers, and to deliver presentations on funding opportunities and their wider public engagement strategy. |
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SLS/WMS Dev Biol and Stem Cell Seminar Series: Professor Enrique Amaya, Division of Cell Matrix Biology and Regenerative Medicine, University of ManchesterGLT3, Warwick Medical School
Seminar: A conserved role for reactive oxygen species during early embryonic development and appendage regeneration Abstract: Enrique’s team are investigating the molecular & cellular mechanisms responsible for scar free wound healing & tissue regeneration in frog embryos & tadpoles. They have shown that tadpole tail amputation induces a sustained production of reactive oxygen species (ROS), which is necessary for tail regeneration. When ROS production following tail amputation is inhibited, both cell proliferation & growth factor signaling fail to occur normally. Intriguingly, the team have found that fertilization also induces a dramatic increase in ROS production, which is also sustained throughout early embryogenesis. Indeed, if they inhibit or attenuate ROS production following fertilization, cell cycle progression & growth factor signaling are also inhibited or attenuated, respectively. Thus, they have found many remarkable parallels in the induction, maintenance & roles for ROS during tissue regeneration and those following fertilization & during embryogenesis. Indeed, both injury & fertilization seem to set in motion a similar series of events, & as such, they have begun to think of fertilization as an injury, which induces development, in much the same way that injury induces a regenerative response in post-embryonic stages. Thus, Enrique postulates that a successful regenerative response is dependent on a return to an embryonic-like state of cellular oxidation, which facilitates cell cycle progression & growth factor signaling. |