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LTP+LTD and Intracellular Dynamics

Working with Zhang XJ and Goldbeter A., we are developing models [1] to account for experimentally observed intracellular signalling pathways. Long term goal is to integrate subcellular, cellular (my colleague, Prof. B. Tirozzi from Rome I University, is working on modelling CA1 neurons), network and behaviour level to study learning and memory (see below).

ltp_ltd.png


Figure: A schematic diagram of the intracellular signalling pathway which leads to LTP and LTD. For details, please refer to the following paper [1].

[1] Zhang XJ, Goldbeter A., and Feng JF, A biophysical model of CREB-modulated synaptic plasticity (in preparation).