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Single Neuron Dynamics

We have worked in the area for many years: abstract model such as the integrate and fire model and biophysically realistic model. Early work included a biophysical model for the mitral cell [1], a biophysical model for CGC cell [2] etc. Recent work is on modelling Purkinje cell in cerebellum with a few thousand compartments (M. Forrest, M. Wall et al.) [3].

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Figure: Spontaneous activity of a Purkinje cell with ionic pumps.

Voltage-dependent gating of the tandem pore potassium channel TASK-3


[1] Davison A.P., Feng J.F., and Brown D (2003) Dendrodendritic inhibition and odour-induced synchronization in a detailed olfactory bulb model, J. Neurophysiology vol. 90, 1921-193.

[2] ES Nikitin, DV Vavoulis, Feng J.F., M O’Shea, PR Benjamin & G Kemenes(2008) Persistent sodium current is a non-synaptic substrate for long-term memory Current Biology vol. 18: 1221-1226

[3] M Forrest, M Wall, D Press, J Feng (2010) The sodium-potassium pump controls the spontaneous firing of the cerebellar Purkinje neuron (in preparation).

[4] Ashmole I, Vavoulis DV, Stansfeld PJ, Mehta PR, Feng JF, Sutcliffe MJ, Stanfield PR (2009) The response of the tandem pore potassium channel TASK-3 (K(2P)9.1) to voltage: gating at the cytoplasmic mouth, J Physiol. 2009 Oct 15;587(Pt 20):4769-83. Epub 2009 Aug 24.

[5] Vavoulis DV, Nikitin ES, Kemenes I, Marra V, Feng J, Benjamin PR, Kemenes G. (2010) Balanced plasticity and stability of the electrical properties of a molluscan modulatory interneuron after classical conditioning: a computational study, Front Behav Neurosci. 2010 May 5; 4:19.