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Samuel Jefferyes (Warwick Systems Biology)

Modelling the shape manifolds of migrating cells

Cell motility plays a crucial role in many physiological processes. Examples include wound healing and cancer cell metastasis. This motility is powered by intracellular mechanisms, thus analysing cell shapes is fundamental to mapping cellular behaviour. I will present a non-linear model for learning the intrinsic low-dimensional structure of cell shape manifolds. I will also discuss a novel extension of the non-linear embedding for reverse mapping of an arbitrary point in the low-dimensional shape space which can be used to traverse the shape manifold and generate synthetic sequences of migrating cells.

Short Bio

Sam completed his undergraduate degree in Maths at Warwick in July 2010. Since then, he has been studying towards his MSc degree, leading to PhD, in Systems Biology. Presently, he is working with Dr Nasir Rajpoot on his dry project.

Date/Time & Venue

2pm on Tue the 14th of June, 2011 in CS.101