Department of Computer Science
Room MB5.30, Mathematical Sciences Building
University of Warwick, CV4 7AL, United Kingdom
Tel: +44 (0) 24 761 50252
My main research interest is to understand principles of self-organisation in animal cell motion and cellular signalling. We combine quantitative image analysis with computational modelling to address problems ranging from the multicellular to the molecular level.
Examples of current projects are blebbing in Dictyostelium, cell movements during early chick development, and validation of mathematical models for cell orientation. Software we develop include our widely-used QuimP software for correlating cortical cell fluorescence with membrane movements, and LineageTracker, a multi feature cell tracker which allows to incorporate time-varying features to detect cell divisions. CellTracker is specifically dedicated to measuring periodic nuclear-cytoplasmic translocations of transcription factors. Current focus is on extending these methods to 3D and most recently we started to develop novel methods for GPU based real-time processing of light sheet microscopy data.
Current Research Projects
BB/R004579/1: Reconstructing cell surface dynamics from lightsheet microscopy data
BB/M01150X/1: QuimP software for quantifying cellular morphodynamics
BB/K003097/1: Systems Biology analysis of biological timers and inflammation
The Software Sustainability Institute cultivates world-class research with software. The Institute is based at the Universities of Edinburgh, Manchester, Southampton and Oxford.
SSI support development of our QuimP software.