Title

Professor

Contact

Department of Computer Science
Room 344, Senate House
University of Warwick, CV4 7AL, United Kingdom

E-mail: T.Bretschneider@warwick.ac.uk
Tel: +44 (0) 24 761 50252

Research Interests

My main research interest is to understand principles of self-organisation in animal cell motion and cellular signalling. We combine quantitative image analysis with computational modelling to address problems ranging from the multicellular to the molecular level.
Examples of current projects are blebbing in Dictyostelium, cell movements during early chick development, and validation of mathematical models for cell orientation. Software we develop include our widely-used QuimP software for correlating cortical cell fluorescence with membrane movements, and LineageTracker, a multi feature cell tracker which allows to incorporate time-varying features to detect cell divisions. CellTracker is specifically dedicated to measuring periodic nuclear-cytoplasmic translocations of transcription factors. Current focus is on extending these methods to 3D and most recently we started to develop novel methods for GPU based real-time processing of light sheet microscopy data.

Current Research Projects

 

BB/R004579/1: Reconstructing cell surface dynamics from lightsheet microscopy data

BB/M01150X/1: QuimP software for quantifying cellular morphodynamics

BB/K003097/1: Systems Biology analysis of biological timers and inflammation

_{The Software Sustainability Institute cultivates world-class research with software. The Institute is based at the Universities of Edinburgh, Manchester, Southampton and Oxford.}

SSI support development of our QuimP software.

Publications

Full list; Google Scholar; Scopus; orcid.org/0000-0002-5317-603X

Further Affiliations

I am also a member of the Zeeman Institute for Systems Biology & Infectious Disease Epidemiology Research (SBIDER) and the Centre for Mechanochemical Cell Biology.

Office Hours for Personal Tutees and CS126 Students, DCS, Room 331

Tuesday 9:30 – 10:30
Thursday 16:00 – 17:00

PhD positions are available through MIBTP