Professor Christopher Dowson
Professor of Microbiology
Email: C.G.Dowson@warwick.ac.uk
Phone: 024 765 23534
Office: IBRB2.24
Dowson webpage
Research Clusters
Warwick Centres and GRPs
Health GRP (AMR theme co-lead)
Warwick Antimicrobial Interdisciplinary Centre (WAMIC)
Warwick Antimicrobial Screening Facility
Sir Howard Dalton Centre for Translational Mechanistic Enzymology (Co-Director)
Vacancies and Opportunities
For postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.
Research Interests
Professor Chris G Dowson has, for many years, examined the emergence and evolution of antibiotic resistance across a wide range of bacteria. His recent focus has been to better understand how penicillin targets bacteria. This began during his postdoctoral time at the University of Sussex, in the laboratory of Professor Spratt (1986-1990) and subsequently with his Lister Institute Centenary Fellowship (1991-1996). He currently holds a personal chair at Warwick University and is a past member of the Medical Research Council Infections and Immunity Board. He has established the Sir Howard Dalton Centre HDC for Translational Mechanistic Enzymology, the Warwick Antimicrobial Interdisciplinary Centre WAMIC, location of the Medicines Discovery Catapult MDC Laboratory facility at Warwick and has been involved with philanthropic research fundraising regionally across Warwickshire for the past 16 years with the Medical and Life Sciences Research Fund MLSRF and the national antibiotic discovery charity Antibiotic Research UK ANTRUK.
Chris' research has been funded by BBSRC, EPSRC, MRC, NIH, Wellcome Trust, smaller charities and industry. It is highly collaborative, involving teams of biologists, chemists, engineers and physicists across universities in the UK SWON Alliance CA, CHN Accelerate CHUNK US, SA H3D, EU, AUS to help drive innovations from this research forward to a commercial outcome, which includes the development and use of high throughput biochemical assays and structural determination using the XChem platform at Diamond Light source and virtual reality to visualise antibiotic: target protein interactions. Industry partners past and present include AstraZeneca, Basilea, BicycleTx, Cubist, LifeArc, Merck, Novartis, Novobiotic, GSK and supported recently in AMR SME engagement with the Medicines Discovery Catapult MDC at Warwick and currently the Antimicrobial Screening Facility at Warwick. He is currently engaged in the open source antibiotics discovery program and helping to develop and influence global AMR discovery policy and training for the next generation of AMR leaders. This has leapt forward with a £1.5M donation from the GB Sasakawa Foundation to drive UK-Japan collaboration to tackle AMR. This award will support two policy fellows, one from UKHSA the 'Dame Sally Davies Fellowship' and another NCGM, Tokyo the 'Mr Yasuhisa Shinozaki Fellowship' plus four science programs arising from the GBSF/HDC Tokyo workshop March 2024
Research: Technical Summary
The development of new reagents and new assays are crucial underpinning technologies enabling a multi-target focus to antibiotic discovery, with priorities in peptidoglycan biosynthesis and protein biosynthesis (aminoacyl tRNA synthetases, aaRS). The focus of my research is peptidoglycan biosynthesis as an enduringly attractive target or antibiotic discovery, including the multi-targeting of penicillin-binding proteins and Mur ligases.
I am a Co-Director of the Sir Howard Dalton Centre for Translational Mechanistic Enzymology. The Centre brings takes an interdisciplinary approach to drive innovative solutions for antimicrobial discovery, and build research and training capacity to address the global challenge of antimicrobial resistance:
- Enzymology: Protein production, substrate synthesis, kinetic characterisation, developing probe compounds, assay development, High-throughput screening and inhibitor discovery
- Structural Biology: X-Ray Crystallography, NMR, High Resolution Imaging (Electron Microscopy, Cryo-Electron Microscopy, Light Microscopy
- Computational Modelling: Systems modelling and structure-based modelling to develop mechanistic insights
- Professor in Microbiology, Warwick University 2000-
- Reader in Microbiology, Warwick University 1996-1999
- Lister Institute (Centenary) Research Fellow, Sussex University 1991-1996
- Postdoctoral Research Fellow, Sussex University 1986- 1990
- PhD Microbiology, Bath University 1987
- BSc (hons) Applied Biology, Bath University 1982
Micelli, Carmina, Dai, Yunfei, Raustad, Nicole, Isberg, Ralph R., Dowson, Christopher G., Lloyd, Adrian J., Geisinger, Edward, Crow, Allister and Roper, David I. (2023) A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape. Proceedings of the National Academy of Sciences of the United States of America, 120 (8). e2215237120. doi:10.1073/pnas.2215237120 ISSN 0027-8424.
Stefanini, Irene, Stoakes, Emily, Wu, Houdini H. T., Xu-McCrae, Li, Hussain, Abid, Moat, John, Dowson, Christopher G., David, Miruna D. and Constantinidou, Chrystala (2022) Genomic assembly of clinical Candida glabrata (Nakaseomyces glabrata) isolates reveals within-species structural plasticity and association with In Vitro antifungal susceptibility. Microbiology Spectrum, 10 (6). e01827-22. doi:10.1128/spectrum.01827-22 ISSN 2165-0497.
Dowson, Amanda J., Lloyd, Adrian J., Cuming, Andrew C., Roper, David I., Frigerio, Lorenzo and Dowson, Christopher G. (2022) Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1). pp. 165-179. doi:10.1093/plphys/kiac176 ISSN 1532-2548.
Ghionis, A., Barker, T. and Dowson, Christopher G. (2022) AMR policy dialogue : driving innovative solutions for antimicrobial discovery. Coventry: University of Warwick.
Cama, J., Leszczynski, R., Tang, P. K., Khalid, A., Lok, V., Dowson, Christopher G. and Ebata, A. (2021) To push or to pull? In a post-COVID world, supporting and incentivizing antimicrobial drug development must become a governmental priority. ACS Infectious Diseases, 7 (8). pp. 2029-2042. doi:10.1021/acsinfecdis.0c00681 ISSN 2373-8227.
Newman, Hector, Krajnc, Alen, Bellini, Dom, Eyermann, Charles J., Boyle, Grant A., Paterson, Neil G., McAuley, Katherine E., Lesniak, Robert, Gangar, Mukesh, von Delft, Frank, Brem, Jürgen, Chibale, Kelly, Schofield, Christopher J. and Dowson, Christopher G. (2021) High-throughput crystallography reveals boron-containing inhibitors of a Penicillin-binding protein with di- and tricovalent binding modes. Journal of Medicinal Chemistry, 64 (15). pp. 11379-11394. doi:10.1021/acs.jmedchem.1c00717 ISSN 0022-2623.
York, Anna, Lloyd, Adrian J., del Genio, Charo I., Shearer, Jonathan, Hinxman, Karen, Fritz, Konstantin, Fülöp, Vilmos, Dowson, Christopher G., Khalid, Syma and Roper, David I. (2021) Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane. Structure, 29 (7). pp. 731-742. doi:10.1016/j.str.2021.03.001 ISSN 0969-2126.
Klug, Dana M., Idiris, Fahima I. M., Blaskovich, Mark A. T., von Delft, Frank, Dowson, Christopher G., Kirchhelle, Claas, Roberts, Adam P., Singer, Andrew C. and Todd, Matthew H. (2021) There is no market for new antibiotics : this allows an open approach to research and development. Wellcome Open Research, 6 . 146. doi:10.12688/wellcomeopenres.16847.1 ISSN 2398-502X.
Aggarwal, Surya D. , Lloyd, Adrian J., Yerneni, Saigopalakrishna S., Narciso, Ana Rita, Shepherd, Jennifer, Roper, David I., Dowson, Christopher G., Filipe, Sergio R and Hiller, N Luisa (2021) A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae. Proceedings of the National Academy of Sciences of the United States of America, 118 (14). e2018089118. doi:10.1073/pnas.2018089118 ISSN 0027-8424.
Styles, Kathryn, Thummeepak, Rapee, Leungtongkam, Udomluk, Smith, Sophie, Christie, Gabrielle S., Millard, Andrew D., Moat, John, Dowson, Christopher G., Wellington, Elizabeth M. H., Sitthisak, Sutthirat and Sagona, Antonia P. (2020) Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii. Antibiotics, 9 (4). 200. doi:10.3390/antibiotics9040200 ISSN 2079-6382.
Jacques, Laura C., Panagiotou, Stavros, Baltazar, Murielle, Senghore, Madikay, Khandaker, Shadia, Xu, Rong, Bricio-Moreno, Laura, Yang, Marie, Dowson, Christopher G., Everett, Dean B., Neill, Daniel R. and Kadioglu, Aras (2020) Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin. Nature Communications, 11 (1). 1892 . doi:10.1038/s41467-020-15751-6 ISSN 2041-1723.
Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I. and Dowson, Christopher G. (2020) Substrate and stereochemical control of peptidoglycan cross-linking by transpeptidation by Escherichia coli PBP1B. Journal of the American Chemical Society, 142 (11). pp. 5034-5048. doi:10.1021/jacs.9b08822 ISSN 0002-7863.
Cain, Ricky, Salimraj, Ramya, Punekar, Avinash S., Bellini, Dom, Fishwick, Colin W. G., Czaplewski, Lloyd, Scott, David J., Harris, Gemma, Dowson, Christopher G., Lloyd, Adrian J. and Roper, David I. (2019) Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase. Journal of Medicinal Chemistry, 62 (21). pp. 9703-9717. doi:10.1021/acs.jmedchem.9b01131 ISSN 0022-2623.
Bellini, Dom, Koekemoer, Lizbé, Newman, Hector and Dowson, Christopher G. (2019) Novel and improved crystal structures of H. influenzae, E. coli and P. aeruginosa penicillin-binding protein 3 (PBP3) and N. gonorrhoeae PBP2 : toward a better understanding of β-Lactam target-mediated resistance. Journal of Molecular Biology, 431 (18). pp. 3501-3519. doi:10.1016/j.jmb.2019.07.010 ISSN 0022-2836.
Hind, Charlotte K., Dowson, Christopher G., Sutton, J. Mark, Jackson, Thomas, Clifford, Melanie, Garner, R. Colin and Czaplewski, Lloyd (2019) Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens. Antimicrobial Agents and Chemotherapy, 63 . e00769. doi:10.1128/AAC.00769-19 ISSN 0066-4804.
Hu, Qingfeng, Yu, Yan, Gu, Dongshi, Xie, Li, Chen, Xingrou, Xu, Ning, Ruan, Jennifer Jin, Dowson, Christopher G. and Ruan, Benfang Helen (2019) Precise Measurement of Time Dependent Cell Growth and Detection of Partial Drug Resistance in Infectious Microbial. ACS Infectious Diseases, 5 (7). pp. 1252-1263. doi:10.1021/acsinfecdis.9b00132 ISSN 2373-8227.
Massarweh, Ahmad, Bosco, Michael, Chantret, Isabelle, Léger, Thibaut, Jamal, Layla, Roper, David I., Dowson, Christopher G., Busca, Patricia, Bouhss, Ahmed, Gravier-Pelletier, Christine and Moore, Stuart E. H. (2019) Bacterial lipid II analogs : novel in vitro substrates for mammalian oligosaccharyl diphosphodolichol diphosphatase (DLODP) activities. Molecules, 24 (11). 2135. doi:10.3390/molecules24112135 ISSN 1420-3049.
Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J. and Brem, Jürgen (2019) Profiling interactions of vaborbactam with metallo-β-lactamases. Bioorganic & Medicinal Chemistry Letters, 29 (15). pp. 1981-1984. doi:10.1016/j.bmcl.2019.05.031 ISSN 0960-894X.
Dougan, Gordon, Dowson, Chris and Overington, John (2019) Meeting the discovery challenge of drug-resistant infections : progress and focusing resources. In: Next Generation Antibiotic Discovery Symposium, Jan 2018. Published in: Drug Discovery Today, 24 (2). pp. 452-461. doi:10.1016/j.drudis.2018.11.015 ISSN 1359-6446.
Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G. and Lewandowski, Józef R. (2018) Structural studies suggest aggregation as one of the modes of action for teixobactin. Chemical Science, 9 (47). pp. 8850-8859. doi:10.1039/c8sc03655a ISSN 2041-6520.
Öster, Carl, Walkowiak, Grzegorz P., Hughes, Dallas E., Spoering, Amy L., Peoples, Aaron J., Catherwood, Anita C., Tod, Julie A., Lloyd, Adrian J., Herrmann, Torsten, Lewis, Kim, Dowson, Christopher G. and Lewandowski, Józef R. (2018) Data for Structural studies suggest aggregation as one of the modes of action for teixobactin. [Dataset]
Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian J., Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Biguanide iridium(III) complexes with potent antimicrobial activity. Journal of Medicinal Chemistry, 61 (16). pp. 7330-7344. doi:10.1021/acs.jmedchem.8b00906 ISSN 1520-4804.
Chen, Feng, Moat, John, McFeely, Daniel, Clarkson, Guy J., Hands-Portman, Ian, Furner-Pardoe, Jessica P., Harrison, Freya, Dowson, Christopher G. and Sadler, P. J. (2018) Data for Biguanide iridium(III) complexes with potent antimicrobial activity. [Dataset]
Punekar, Avinash S., Samsudin, Firdaus, Lloyd, Adrian J., Dowson, Christopher G., Scott, David J., Khalid, Syma and Roper, David I. (2018) The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization. The Cell Surface, 2 . pp. 54-66. doi:10.1016/j.tcsw.2018.06.002 ISSN 2468-2330.
Ratamero, Erick Martins, Bellini, Dom, Dowson, Christopher G. and Römer, Rudolf A. (2018) Touching proteins with virtual bare hands : visualizing protein–drug complexes and their dynamics in self-made virtual reality using gaming hardware. Journal of Computer-Aided Molecular Design, 32 (6). pp. 703-709. doi:10.1007/s10822-018-0123-0 ISSN 1573-4951.
Hrast, Martina, Jukič, Marko, Patin, Delphine, Tod, Julie, Dowson, Christopher G., Roper, David I., Barreteau, Hélène and Gobec, Stanislav (2018) In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB. Chemical Biology & Drug Design, 91 (6). pp. 1101-1112. doi:10.1111/cbdd.13172 ISSN 1747-0285.
Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, Fülöp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S. and Roper, David I. (2017) Inhibition of D-Ala : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8 (1). 1939 . doi:10.1038/s41467-017-02118-7 ISSN 2041-1723.
Sychantha, David, Jones, Carys S., Little, Dustin J., Moynihan, Patrick J., Robinson, Howard, Galley, Nicola F., Roper, David I., Dowson, Christopher G., Howell, P. Lynne and Clarke, Anthony J. (2017) In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA). PLOS Pathogens, 13 (10). e1006667. doi:10.1371/journal.ppat.1006667 ISSN 1553-7374.
Kuroki, Agnès, Sangwan, Parveen, Qu, Yue, Peltier, Raoul, Sanchez-Cano, Carlos, Moat, John, Dowson, Christopher G., Williams, Elizabeth G. L., Locock, Katherine E. S., Hartlieb, Matthias and Perrier, Sébastien (2017) Sequence control as a powerful tool for improving the selectivity of antimicrobial polymers. ACS Applied Materials & Interfaces, 9 (46). pp. 40117-40126. doi:10.1021/acsami.7b14996 ISSN 1944-8244.
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng-Ruh, Linington, Roger G., Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017) Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 . 14414 . doi:10.1038/ncomms14414 ISSN 2041-1723.
Vajs, Jure, Proud, Conor, Brozovic, Anamaria, Gazvoda, Martin, Lloyd, Adrian J., Roper, David I., Osmak, Maja, Košmrlj, Janez and Dowson, Christopher G. (2017) Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. European Journal of Medicinal Chemistry, 127 . pp. 223-234. doi:10.1016/j.ejmech.2016.12.060 ISSN 0223-5234.
Nelson, E Andrea, Wright-Hughes, Alexandra, Brown, Sarah, Lipsky, Benjamin A, Backhouse, Michael, Bhogal, Moninder, Ndosi, Mwidimi, Reynolds, Catherine, Sykes, Gill, Dowson, Christopher G., Edmonds, Michael, Vowden, Peter, Jude, Edward B., Dickie, Tom and Nixon, Jane (2016) Concordance in diabetic foot ulceration : a cross-sectional study of agreement between wound swabbing and tissue sampling in infected ulcers. Health Technology Assessment, 20 (82). doi:10.3310/hta20820 ISSN 1366-5278.
Dowson, Christopher G. and O’Reilly, Steven (2016) DNA methylation in fibrosis. European Journal of Cell Biology, 95 (9). pp. 323-330. doi:10.1016/j.ejcb.2016.06.003 ISSN 0171-9335.
Araújo, Carlos Leonardo de A., Dias, Larissa M., Veras, Adonney A. O., Alves, Jorianne T. C., Cavalcante, Ana Lídia Q., Dowson, Christopher G., Azevedo, Vasco, Ramos, Rommel T. J., Silva, Artur and Carneiro, Adriana R. (2016) Whole-genome sequence of Corynebacterium pseudotuberculosis 262 biovar equi isolated from cow milk. Genome Announcements, 4 (2). e00176. doi:10.1128/genomeA.00176-16 ISSN 2169-8287.
Usha, Veeraraghavan, Lloyd, Adrian J., Roper, David I., Dowson, Christopher G., Kozlov, Guennadi, Gehring, Kalle, Chauhan, Smita, Imam, Hasan T., Blindauer, Claudia A. and Besra, Gurdyal S. (2016) Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase. Scientific Reports, 6 . 23191. doi:10.1038/srep23191 ISSN 2045-2322.
Smith, Nichola A., Zhang, Pingyu, Greenough, Simon E., Horbury, Michael D., Clarkson, Guy J., McFeely, Daniel, Habtemariam, Abraha, Salassa, Luca, Stavros, Vasilios G., Dowson, Christopher G. and Sadler, P. J. (2016) Combatting AMR : photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity. Chemical Science, 8 (1). pp. 395-404. doi:10.1039/C6SC03028A ISSN 2041-6520.
Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine Tetraphosphoadenosine drives a continuous ATP-release assay for Aminoacyl-tRNA synthetases and other Adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.
Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I. and Dowson, Christopher G. (2013) Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes. ACS Chemical Biology, 8 (10). pp. 2157-2163. doi:10.1021/cb400248f ISSN 1554-8929.
Rushton, Laura, Sass, Andrea, Baldwin, Adam, Dowson, Christopher G., Donoghue, Denise and Mahenthiralingam, Eshwar (2013) Key role for efflux in the preservative susceptibility and adaptive resistance of burkholderia cepacia complex bacteria. Antimicrobial Agents and Chemotherapy, 57 (7). pp. 2972-2980. doi:10.1128/AAC.00140-13 ISSN 0066-4804.
Dobrzanska, Dorota A., Cooper, A. (Amy), Dowson, Christopher G., Evans, Stephen D., Fox, David J., Johnson, Benjamin R., Biggs, Caroline I., Randev, Rajan, Stec, Helena M., Taylor, Paul C. and Marsh, Andrew (2013) Oxidation of tertiary amine-derivatized surfaces to control protein adhesion. Langmuir, Volume 29 (Number 9). pp. 2961-2970. doi:10.1021/la4003719 ISSN 0743-7463.
Castro, Thiago L. P., Seyffert, Nubia, Ramos, Rommel T. J., Barbosa, Silvanira, Carvalho, Rodrigo D. O., Pinto, Anne Cybelle, Carneiro, Adriana Ribeiro, Silva, Wanderson Marques, Pacheco, Luis G. C., Downson, Christopher G., Schneider, Maria P. C., Miyoshi, Anderson, Azevedo, V. (Vasco) and Silva, Artur (2013) Ion torrent-based transcriptional assessment of a Corynebacterium pseudotuberculosis equi strain reveals denaturing high-performance liquid chromatography a promising rRNA depletion method. Microbial Biotechnology, Volume 6 (Number 2). pp. 168-177. doi:10.1111/1751-7915.12020 ISSN 1751-7907.
Ruane, Karen M., Lloyd, Adrian J., Fülöp, Vilmos, Dowson, Christopher G., Barreteau, Hélène, Boniface, Audrey, Dementin, Sébastien, Blanot, Didier, Mengin-Lecreulx, Dominique, Gobec, Stanislav, Dessen, Andréa and Roper, David I. (2013) Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex. Journal of Biological Chemistry, Volume 288 (Number 46). Article number 33439. doi:10.1074/jbc.M113.508135 ISSN 0021-9258.
Viguetti, S. Z., Pacheco, L. G. C., Santos, L. S., Soares, S. C., Bolt, F., Baldwin, Adam, Dowson, Christopher G., Rosso, M. L., Guiso, N., Miyoshi, A., Hirata, R., Mattos-Guaraldi, A. L. and Azevedo, V. (2012) Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil. Epidemiology and Infection, Volume 140 (Number 4). pp. 617-620. doi:10.1017/S0950268811000963 ISSN 0950-2688.
Dobrzanska, Dorota A., Cooper, Amy L., Dowson, Christopher G., Evans, Stephen D., Haynes, Tommy, Johnson, Benjamin R. G., Stec, Helena M., Taylor, Paul C. and Marsh, Andrew (2012) Protein-adhesive and protein-resistant functionalized silicon surfaces. Langmuir . (Submitted)
Pacheco, Luis G. C., Castro, Thiago L. P., Carvalho, Rodrigo D. O., Moraes, Pablo M., Dorella, Fernanda A., Carvalho, Natália B., Slade, Susan E., Scrivens, James H., Feelisch, Martin, Meyer, Roberto, Miyoshi, Anderson, Oliveira, Sérgio C., Dowson, Christopher G. and Azevedo, Vasco (2012) A role for sigma factor σE in corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress. Frontiers in Microbiology, Volume 3 . Article number 126. doi:10.3389/fmicb.2012.00126 ISSN 1664-302X.
McDowell, A. (Andrew), Gao, Anna, Barnard, E. (Emma), Fink, Colin, Murray, Philip I., Dowson, Christopher G., Nagy, I. (István), Lambert, Peter A. and Patrick, Sheila (2011) A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens. Microbiology, Vol.157 (No.7). pp. 1990-2003. doi:10.1099/mic.0.049676-0 ISSN 1350-0872.
Pacheco, Luis G. C., Slade, Susan E., Seyffert, Núbia, Santos, Anderson R., Castro, Thiago L. P., Silva, Wanderson M., Santos, Agenor V., Santos, Simone G., Farias, Luiz M., Carvalho, Maria A. R., Pimenta, Adriano M. C., Meyer, Roberto, Silva, Artur, Scrivens, James H., Oliveira, Sérgio C., Miyoshi, Anderson, Dowson, Christopher G. and Azevedo, Vasco (2011) A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis. BMC Microbiology, Vol.11 . article no. 12. doi:10.1186/1471-2180-11-12 ISSN 1471-2180.
Bugg, Tim, Braddick, Darren, Dowson, Christopher G. and Roper, David I. (2011) Bacterial cell wall assembly : still an attractive antibacterial target. Trends in Biotechnology, Vol.29 (No.4). pp. 167-173. doi:10.1016/j.tibtech.2010.12.006 ISSN 0167-7799.
Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. (Michael J.), Bearup, Daniel James, Roper, David I., Dowson, Christopher G., Bugg, Tim and Evans, Neil D. (2011) Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis. Computer Methods and Programs in Biomedicine, Vol.104 (No.2). pp. 70-80. doi:10.1016/j.cmpb.2010.07.009 ISSN 01692607.
Aaron, Shawn D., Vandemheen, Katherine L., Ramotar, Karam, Giesbrecht-Lewis, Tracy, Tullis, Elizabeth, Freitag, Andreas, Paterson, Nigel, Jackson, Mary, Lougheed, M. Diane, Dowson, Christopher G., Kumar, Vijay, Ferris, Wendy, Chan, Francis, Doucette, Steve and Fergusson, Dean (2010) Infection with transmissible strains of pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis. JAMA: The Journal of the American Medical Association, Vol.304 (No.19). pp. 2145-2153. doi:10.1001/jama.2010.1665 ISSN 0098-7484.
Bolt, Frances, Cassiday, Pamela, Tondella, Maria Lucia, DeZoysa, Aruni, Efstratiou, Androulla, Sing, Andreas, Zasada, Aleksandra, Bernard, Kathryn, Guiso, Nicole, Badell, Edgar, Rosso, Marie-Laure, Baldwin, Adam and Dowson, Christopher G. (2010) Multilocus sequence typing identifies evidence for recombination and two distinct lineages of corynebacterium diphtheriae. Journal of Clinical Microbiology, Vol.48 (No.11). pp. 4177-4185. doi:10.1128/JCM.00274-10 ISSN 0095-1137.
Hall, Aron J., Cassiday, Pamela K., Bernard, Kathryn A., Bolt, Frances, Steigerwalt, Arnold G., Bixler, Danae, Pawloski, Lucia C., Whitney, Anne M., Iwaki, M., Baldwin, Adam, Dowson, Christopher G., Komiya, Takako, Takahashi, Motohide, Hinrikson, Hans P. and Tondella, Maria L. (2010) Novel Corynebacterium diphtheriae in domestic cats. Emerging Infectious Diseases , Vol.16 (No.4). doi:10.3201/eid1604.091107 ISSN 1080-6059.
Drevinek, Pavel, Baldwin, Adam, Lindenburg, Laurens, Joshi, Lovleen Tina, Marchbank, Angela, Vosahlikova, Sarka, Dowson, Christopher G. and Mahenthiralingam, Eshwar (2010) Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping. Journal of Clinical Microbiology, Vol.48 (No.1). pp. 34-40. doi:10.1128/JCM.01433-09 ISSN 0095-1137.
Waine, David J., Honeybourne, David, Smith, E. Grace, Whitehouse, Joanna L. and Dowson, Christopher G. (2009) Cross-sectional and longitudinal multilocus sequence typing of Pseudomonas aeruginosa in cystic fibrosis sputum samples. Journal of Clinical Microbiology, Vol.47 (No.11). pp. 3444-3448. doi:10.1128/JCM.00459-09 ISSN 0095-1137.
Dumville, J. C., Worthy, G., Soares, M. O., Bland, J. M., Cullum, N., Dowson, Christopher G., Iglesias, C., McCaughan, D., Mitchell, J. L., Nelson, E. A. and Torgerson, D. J. (2009) VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers. Health Technology Assessment, Vol.13 (No.55). p. 1. ISSN 1366-5278 doi:10.3310/hta13550
Baldwin, Adam, Loughlin, Michael, Dr., Caubilla-Barron, Juncal, Kucerova, Eva, Manning, Georgina, Dowson, Christopher G. and Forsythe, S. J. (Steve J.) (2009) Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes. BMC Microbiology, Vol.9 (Article 223). doi:10.1186/1471-2180-9-223 ISSN 1471-2180.
Bearup, Daniel James, Evans, Neil D., Dowson, Christopher G. and Chappell, M. J. (Michael J.) (2009) Use of structural identifiability analysis to inform experimental design for enzyme kinetics. In: The 9th International Conference on Systems Biology (ICSB2008), Gothenburg, Sweden, Aug 22-28, 2008. Published in: 9th International Conference on Systems Biology 2008 (ICSB 2008): Abstract Book
Spilker, Theodore, Baldwin, Adam, Bumford, Amy, Dowson, Christopher G., Mahenthiralingam, Eshwar and LiPuma, John J. (2009) Expanded multilocus sequence typing for Burkholderia species. Journal of Clinical Microbiology, Vol.47 (No.8). pp. 2607-2610. doi:10.1128/JCM.00770-09 ISSN 0095-1137.
Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, Francois, Maaroufi, Halim, Clarke, Thomas B., Blewett, Ann, Dowson, Christopher G., Roper, David I., Bugg, Tim and Levesque, Roger C. (2009) Pseudomonas aeruginosa MurE amide ligase : enzyme kinetics and peptide inhibitor. Biochemical Journal, Vol.421 (No. 2). pp. 263-272. doi:10.1042/BJ20081395 ISSN 0264-6021.
Bernard, K., Schindle, S., Burdz, T., Wiebe, D., Reimer, A., Dowson, Christopher G., Bolt, F. and Baldwin, Adam (2009) The use of a multi locus sequence typing scheme to characterize Canadian isolates of Corynebacterium diphtheriae. In: 26th International Congress of Chemotherapy and Infection, Toronto, Canada, June 18-21, 2009. Published in: International Journal of Antimicrobial Agents, Vol.34 (Suppl. 2). S11-S11. doi:10.1016/S0924-8579(09)70177-3 ISSN 0924-8579.
Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Mok, B. James, Caddick, Stephen, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2009) Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors. Bioorganic & Medicinal Chemistry, Vol.17 (No.9). pp. 3443-3455. doi:10.1016/j.bmc.2009.03.028 ISSN 0968-0896.
Clarke, Thomas B., Kawai, Fumihiro, Park, Sam-Yong, Tame, Jeremy R. H., Dowson, Christopher G. and Roper, David I. (2009) Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4. Biochemistry, Vol.48 (No.12). pp. 2675-2683. doi:10.1021/bi801993x ISSN 0006-2960.
VenUS II Team (Including: Dumville, Jo C., Worthy, Gill, Bland, J. Martin, Cullum, Nicky, Dowson, Christopher G., Iglesias, Cynthia, Mitchell, Joanne L., Nelson, E. Andrea, Soares, Marta O. and Torgerson, David J.). (2009) Larval therapy for leg ulcers (VenUS II): randomised controlled trial. British Medical Journal, Vol.338 . Article no. b773. doi:10.1136/bmj.b773 ISSN 0959-8146.
Rose, Helen, Baldwin, Adam, Dowson, Christopher G. and Mahenthiralingam, Eshwar (2009) Biocide susceptibility of the Burkholderia cepacia complex. Journal of Antimicrobial Chemotherapy, Vol.63 (No.3). pp. 502-510. doi:10.1093/jac/dkn540 ISSN 0305-7453.
Ward, Philip N., Holden, Matthew T. G., Leigh, James A., Lennard, Nicola, Bignell, Alexandra, Barron, Andy, Clark, Louise, Quail, Michael A., Woodward, John, Barrell, Bart G., Egan, Sharon A., Field, Terence R., Maskell, Duncan, Kehoe, Michael, Dowson, Christopher G. and Chanter, Neil (2009) Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis. BMC Genomics, Vol.10 . Article No. 54. doi:10.1186/1471-2164-10-54 ISSN 1471-2164.
Vanlaere, Elke, Baldwin, Adam, Gevers, Dirk, Henry, Deborah, De Brandt, Evie, LiPuma, John J., Mahenthiralingam, Eshwar, Speert, David P., Dowson, Christopher G. and Vandamme, Peter (2009) Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp nov and Burkholderia lata sp nov. International Journal of Systematic and Evolutionary Microbiology, Vol.59 (Part 1). pp. 102-111. doi:10.1099/ijs.0.001123-0 ISSN 1466-5026.
De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G. and Bugg, Tim (2008) Kinetic characterization of lipid II-Ala:Alanyl-tRNA ligase (MurN) from streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates. Journal of Biological Chemistry, Vol.283 (No.50). pp. 34571-34579. doi:10.1074/jbc.M805807200 ISSN 0021-9258.
Marttinen, Pekka, Baldwin, Adam, Hanage, William P., Dowson, Christopher G. and Mahenthiralingam, Eshwar (2008) Bayesian modeling of recombination events in bacterial populations. BMC Bioinformatics, Vol.9 (No.421). doi:10.1186/1471-2105-9-421 ISSN 1471-2105.
Waine, David J., Honeybourne, David, Smith, E. Grace, Whitehouse, Joanna L. and Dowson, Christopher G. (2008) Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa. Journal of Clinical Microbiology, Vol.46 (No.10). pp. 3491-3493. doi:10.1128/JCM.00357-08 ISSN 0095-1137.
Vanlaere, Elke, LiPuma, John J., Baldwin, Adam, Henry, Deborah, De Brandt, Evie, Mahenthiralingam, Eshwar, Speert, David, Dowson, Christopher G. and Vandamme, Peter (2008) Burkholderia latens sp nov., Burkholderia diffusa sp nov., Burkholderia arboris sp nov., Burkholderia seminalis sp nov and Burkholderia metallica sp nov., novel species within the Burkholderia cepacia complex. International Journal of Systematic and Evolutionary Microbiology, Vol.58 (Part 7). pp. 1580-1590. doi:10.1099/ijs.0.65634-0 ISSN 1466-5026.
Mahenthiralingam, Eshwar, Baldwin, A. (Adam) and Dowson, Christopher G. (2008) Burkholderia cepacia complex bacteria : opportunistic pathogens with important natural biology. Journal of Applied Microbiology, Vol.104 (No.6). pp. 1539-1551. ISSN 1364-5072 doi:10.1111/j.1365-2672.2007.03706.x
Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I. and Dowson, Christopher G. (2008) Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan. Journal of Biological Chemistry, Vol.283 (No.10). pp. 6402-6417. doi:10.1074/jbc.M708105200 ISSN 0021-9258.
Drevinek, Pavel, Baldwin, Adam, Dowson, Christopher G. and Mahenthiralingam, Eshwar (2008) Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia. BMC Microbiology, Vol.8 (No.44). doi:10.1186/1471-2180-8-44 ISSN 1471-2180.
Baldwin, Adam, Mahenthiralingam, Eshwar, Drevinek, Pavel, Pope, Chris, Waine, David J., Henry, Deborah A., Speert, David P., Carter, Phil, Vandamme, Peter, LiPuma, John J. and Dowson, Christopher G. (2008) Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing. Journal of Clinical Microbiology, Vol.46 (No.1). pp. 290-295. doi:10.1128/JCM.01818-07 ISSN 0095-1137.
Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G. and Weiser, Jeffrey N. (2007) Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PL o S Pathogens , Vol.3 (No.8). pp. 1073-1081. doi:10.1371/journal.ppat.0030118 ISSN 1553-7366.
Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G. and Bugg, Tim (2007) Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae. Bioorganic & Medicinal Chemistry Letters, Vol.17 (No.16). pp. 4654-4656. doi:10.1016/j.bmcl.2007.05.071 ISSN 0960-894X.
Lysenko, Elena S., Clarke, Thomas B., Shchepetov, Mikhail, Ratner, Adam J., Roper, David I., Dowson, Christopher G. and Weiser, Jeffrey N. (2007) Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing. PLoS Pathogens, Vol.3 (No.8). pp. 1073-1081. doi:10.1371/journal.ppat.0030118 ISSN 1553-7374.
Dalmastri, Claudia, Baldwin, Adam, Tabacchioni, Silvia, Bevivino, Annamaria, Mahenthiralingam, Eshwar, Chiarini, Luigi and Dowson, Christopher G. (2007) Investigating Burkholderia cepacia complex populations recovered from Italian maize rhizosphere by multilocus sequence typing. Environmental Microbiology, Vol.9 (No.7). pp. 1632-1639. doi:10.1111/j.1462-2920.2007.01273.x ISSN 1462-2912.
Waine, David J., Henry, Deborah A., Baldwin, Adam, Speert, David P., Honeybourne, David, Mahenthiralingam, Eshwar and Dowson, Christopher G. (2007) Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis. Journal of Cystic Fibrosis, Vol.6 (No.3). pp. 215-219. doi:10.1016/j.jcf.2006.10.003 ISSN 1569-1993.
Baldwin, Adam, Mahenthiralingam, Eshwar, Drevinek, Pavel, Vandamme, Peter, Govan, John R., Waine, David J., LiPuma, John J., Chiarini, Luigi, Dalmastri, Claudia, Henry, Deborah A., Speert, David P., Honeybourne, David, Maiden, Martin C. J. and Dowson, Christopher G. (2007) Environmental Burkholderia cepacia complex isolates in human infections. Emerging Infectious Diseases , Vol.13 (No.3). pp. 458-461. doi:10.3201/eid1303.060403 ISSN 1080-6059.
Moore, Lisa J., Gilbey, Andrea M., Dowson, Christopher G., Pridmore, Alison C., Dower, Steven K. and Read, Robert C. (2007) Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics. Journal of Antimicrobial Chemotherapy, Volume 59 (Number 1). pp. 35-42. doi:10.1093/jac/dkl442 ISSN 0305-7453.
Gardner, J. W., Apostolidou, A., Cole, Marina, Dowson, Christopher G., Edmunds, S. and Sehra, G. (2007) Towards a low-cost optical iriosensor system for biomedical immunoassay applications. In: 5th IASTED International Conference on Biomedical Engineering, Innsbruck, Austria, 14-16 Feb 2007. Published in: Proceedings of the Fifth IASTED International Conference on Biomedical Engineering pp. 277-282. ISBN 9780889866485.
Mahenthiralingam, Eshwar, Baldwin, Adam, Drevinek, Pavel, Vanlaere, Elke, Vandamme, Peter, LiPuma, John J. and Dowson, Christopher G. (2006) Multilocus sequence typing breathes life into a microbial metagenome. PLoS One, Vol.1 (No.1). doi:10.1371/journal.pone.0000017 ISSN 1932-6203.
Schouten, James A., Bagga, Sangeev, Lloyd, Adrian J., De Pascale, Gianfranco, Dowson, Christopher G., Roper, David I. and Bugg, Timothy D. H. (2006) Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing d-cysteine at position 4 or 5. Molecular BioSystems, 2 (10). pp. 484-491. doi:10.1039/b607908c ISSN 1742-206X.
Tötemeyer, Sabine, Sheppard, Mark, Lloyd, Adrian, Roper, David I., Dowson, Christopher G., Underhill, David, Murray, Peter, Maskell, Duncan and Bryant, Clare (2006) IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. Journal of Immunology, Vol.176 (No.8). pp. 4804-4810. ISSN 0022-1767.
Nelson, E. A., O'Meara, S., Craig, D, Iglesias, C., Golder, S, Dalton, J, Claxton, K, Bell-Syer, S.E.M., Jude, E, Dowson, Christopher G., Gadsby, Roger, O'Hare, J. Paul and Powell, John (2006) A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers. Health Technology Assessment, Volume 10 (Number 12). 1-+. ISSN 1366-5278
Smith, Edward M., Green, Laura E., Medley, Graham, Bird, H. E. and Dowson, Christopher G. (2005) Multilocus sequence typing of Staphylococcus aureus isolated from high-somatic-cell-count cows and the environment of an organic dairy farm in the United Kingdom. Journal of Clinical Microbiology, Vol.43 (No.9). pp. 4731-4736. doi:10.1128/JCM.43.9.4731-4736.2005 ISSN 0095-1137.
Smith, Edward M., Green, Laura E., Medley, Graham, Bird, H. E., Fox, L. K., Schukken, Y. H., Kruze, J. V. , Bradley, Andrew J., Zadoks, Ruth N. and Dowson, Christopher G. (2005) Multilocus sequence typing of intercontinental bovine Staphylococcus aureus isolates. Journal of Clinical Microbiology, Vol.43 (No.9). pp. 4737-4743. doi:10.1128/JCM.43.9.4737-4743.2005 ISSN 0095-1137.
Gardner, J. W., Hines, E.L. and Dowson, Christopher G. (2004) Smelling illness. London, UK: Ingenia.
Yates, J. W. T., Gardner, J. W., Chappell, M. J. (Michael J.), Bolt, F., Beeby, L. and Dowson, Christopher G. (2003) Chemical sensor screening of blood samples : robust analysis via data set reduction. In: 5th IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, 21-23 Aug 2003. Published in: Modellling and Control in Biomedical Systems 2003 (including Biology Systems) pp. 289-294. ISBN 0080441599. ISSN 0962-9505.
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Antimicrobial Resistance: Breakthrough Compound Discovery through Mechanistic Studies combined with Bicycle Technology and Target Validation - BBSRC Prosperity Partnership Full Stage - March 2023 | BBSRC | 15 Nov 2023 | 14 Nov 2026 |
| MEDICAL RESEARCH FOUNDATION NATIONAL PHD TRAINING PROGRAMME IN ANTIMICROBIAL RESISTANCE RESEARCH - A-code | Medical Research Foundation | 01 Oct 2017 | 30 Sept 2025 |
| Healthcare Associated Infections and Antimicrobial Resistance at Imperial College | National Institute for Health Research (NIHR DoH) | 01 Apr 2020 | 31 Mar 2025 |
| Enabling public and private partnership platforms to accelerate antibiotic discovery linked to 72691 | Rosalind Franklin Institute | 21 Jul 2022 | 20 Nov 2024 |
| Sulbactam cefepime | ANTRUK Enterprises Limited | 02 Jan 2020 | 31 Mar 2024 |
| Developing mechanistic understanding to improve the activity of bicyclic peptides as novel antimicrobials | MRC | 13 Sept 2021 | 12 Sept 2023 |
| Developing mechanistic understanding to improve the activity of bicyclic peptides as novel antimicrobials linked to 69055 | BicycleTX Ltd | 13 Sept 2021 | 12 Sept 2023 |
| BBSRC Mid-range Equipment ALERT 2021 Application - November 2021 | BBSRC | 01 Aug 2022 | 31 Jul 2023 |
| MRC UK China Hubs | MRC | 01 Jan 2019 | 31 Mar 2022 |
| CoA: CHNUK: Integrated platforms from science to policy in response to antibacterial resistance; linked to Ideate 58956 | UK Research and Innovation | 01 Jul 2020 | 30 Sept 2021 |
| CoA: [Mechanistic understanding of cell wall biosynthesis to combat antimicrobial resistance: Cell Wall AMR]; linked to Ideate 46475 | UK Research and Innovation | 01 Mar 2021 | 28 Aug 2021 |
| Mechanistic understanding of cell wall biosynthesis to combat antimicrobial resistance: Cell Wall AMR | MRC | 01 Jul 2015 | 28 Aug 2021 |
| 19 Alert mid-range Equipment Initiative: equipment to upgrade the 600 NMR console at the NMR facility. | BBSRC | 01 Nov 2020 | 31 Mar 2021 |
| Science City TM1 Clinical Trials (Warwick-led) - Inter Institutional Agreement | Advantage West Midlands | 01 Aug 2009 | 31 Jul 2019 |
| Accelerate CHNUK AMR discovery: Establishing and exploiting a joint China/UK platform to enable high throughput fragment based inhibitor discovery | MRC | 01 Jul 2016 | 30 Jun 2019 |
| Research Project on Penicillin (WCPRS) | Micropathology Limited | 05 Oct 2015 | 04 Apr 2019 |
| Developing the next generation of beta-lactamase inhibitors and monobactum antibiotics - GCRF network grant | Academy of Medical Sciences | 28 Jan 2018 | 27 Jan 2019 |
| Cell wall biosynthesis ? a structural and biochemical characterization of penicillin-binding-proteins Lister summer studentship for Anna Schorfield | Lister Institute of Preventive Medicine | 02 Jul 2018 | 07 Sept 2018 |
| Multi-Targetting of tRNA synthetases: A paradigm shift in combating AMR | MRC | 01 Mar 2015 | 30 Nov 2017 |
| Development of orally active analogs of Teixobactin | Gates Foundation | 08 Feb 2017 | 31 Oct 2017 |
| Cell wall biosynthesis in Yersinia pestis ? a structural and biochemical characterization of penicillin-binding-proteins (Lister Summer Studentship for Rachel Evans) | Lister Institute of Preventive Medicine | 10 Jul 2017 | 01 Sept 2017 |
| Enabling novel penicillin-binding-protein high throughput screens | Wellcome Trust | 01 Jul 2016 | 30 Jun 2017 |
| International exploitation of new reagents and assays for antibiotic discovery | BBSRC | 03 May 2015 | 02 May 2016 |
| FLIP: Enabling exploitation of novel reagents and assays (EnRgy) | BBSRC | 24 Feb 2014 | 23 Feb 2016 |
| Development of assays and reagents in the final steps of peptidoglycan. | AstraZeneca Pharmaceuticals LP | 01 Oct 2013 | 31 Dec 2015 |
| Team CanUK: Novel antibacterial targets, assays, probes and opportunities in bacterial cell wall biogenesis | MRC | 01 Jan 2012 | 31 Dec 2015 |
| BBSRC Link with Astra Zeneca:Reagents and assays to exploit the final steps of peptidoglycan construction | BBSRC | 01 Aug 2013 | 31 Jul 2015 |
| Optimisation of anaerobic digestion (process monitoring) | Guy and Wright Limited | 01 Feb 2010 | 30 Jun 2015 |
| Support for Chris Dowson Research - Medical & Life Sciences Research Fund | Medical and Life Sciences Research Fund | 01 Dec 2013 | 31 Jul 2014 |
| The biochemical characterisation of pivotal enzymes involved in mycobacterial peptidoglycan biosynthesis Birmingham-Warwick PG grant | MRC | 01 May 2011 | 30 Apr 2014 |
| Concordance in Diabetic Foot Ulceration - CODIFI (lead: University of Leeds) | National Institute for Health Research (DoH) | 01 Apr 2011 | 30 Sept 2013 |
| Unesco- loreal Visiting Fellowship for Vita Majce | UNESCO | 01 May 2012 | 30 Apr 2013 |
| Inter-Institutional Agreement Science City TM2 Experimental Medicine (Birmingham-led) | Advantage West Midlands | 20 Jul 2009 | 31 Mar 2012 |
| Match funding for Chris Dowson Micropathology donation | Higher Education Funding Council for England | 01 Feb 2010 | 31 Jan 2011 |
| Funding for Medical Research Fund Arden Fellow - Adam Baldwin | Micropathology Limited | 01 Aug 2008 | 31 Oct 2010 |
| Medical Research Fund Arden Fellowship - Support for Elli Pinnock | Micropathology Limited | 01 Oct 2009 | 17 Sept 2010 |
| UKCan - BACWAN | MRC | 01 Aug 2009 | 30 Apr 2010 |
| UK BACWAN 2 | University of Sheffield | 01 May 2008 | 30 Apr 2010 |
| CASE STUDENTSHIP - Eleanor Pinnock | Micropathology Limited | 01 Oct 2006 | 30 Sept 2009 |
| TIME EXTENSION ONLY - Indistinguishability Analysis for Model Discrimination in Systems Biology: A Feasibility Study Applied to Bacterial Peptidoglycan Biosynthesis | EPSRC | 01 May 2009 | 31 Jul 2009 |
| Indistinguishability Analysis for Model Discrimination in Systems Biology: A Feasibility Study Applied to Bacterial Peptidoglycan Biosynthesis | EPSRC | 01 Apr 2007 | 31 Mar 2009 |
| Indistinguishability Analysis for Model Discrimination in Systems Biology: A Feasibility Study Applied to Bacterial Peptidoglycan Biosynthesis | EPSRC | 01 Apr 2007 | 31 Mar 2009 |
| Funding for Medical Research Fund Arden Fellow - Adam Baldwin | Micropathology Limited | 01 Nov 2008 | 31 Jan 2009 |
| Purchase of Kinetic Spectrophotometer | Eveson Charitable Trust | 01 Feb 2008 | 31 Jan 2009 |
| Comparative Virulence of Clinical, Industrial and Environmental Isolates of the Opportunistic pathogen Pseudomonas Auruginosa - SGM summer studentship | Society for General Microbiology | 21 Jul 2008 | 12 Sept 2008 |
| Funding for Medical Research Fund Arden Fellow - Adam Baldwin | Micropathology Limited | 01 May 2008 | 31 Jul 2008 |
| UK - BaCWAN: UK-Bacterial Cell Wall Assembly Network | MRC | 01 Apr 2006 | 31 Mar 2008 |
| Exploration and Exploitation of the Enzymology of PBP Driven Peptidoglycan Biosynthesis to Discover Novel Non-beta Lactam Antibiotics | MRC | 01 Mar 2005 | 29 Feb 2008 |
| Expanding global databases for CF pathogens burkholderia cepacia complex and pseudomonas aeruginosa in order to investigate emerging infections. | Cystic Fibrosis Trust | 01 Feb 2007 | 31 Jan 2008 |
| MLST Characterisation of Burkholeria cepacia complex orgnaisms | Unilever | 26 Oct 2007 | 31 Dec 2007 |
| Screening for 21st Century cell wall inhibitors active against hospital acquired bacterial infections | Medical Research Fund of Warwick | 01 Jun 2007 | 30 Nov 2007 |
| Molecular Physiology and structural analysis of the innate immune system triggered by bacterial cell wall components | British Pharmacological Society | 01 Oct 2004 | 30 Sept 2007 |
| CASE Studentship: Frances Bolt | Micropathology Limited | 01 Oct 2004 | 30 Sept 2007 |
| Admin Support - Developing rapid diagnostic tools for the control of infectious disease | WPH Charitable Trust | 01 Oct 2004 | 30 Sept 2007 |
| Students into work application - vacation studentship for Duncan Hope | Society for Applied Microbiology | 09 Jul 2007 | 14 Sept 2007 |
| Burkholderia Cepacia Complex Isolates from Industrial Origins | Unilever UK Central Resources Limited | 01 Oct 2006 | 31 Jan 2007 |
| Multi locus sequence typing, rapid identification, evoluction and gene flux within Burkholderia cepacia complex isolates. | Wellcome Trust | 03 Jan 2004 | 31 Dec 2006 |
| Student Research Training Project | South Warwickshire General Hospitals NHS Trust | 07 Nov 2005 | 06 Nov 2006 |
| Screening for 21st century cell wall inhibitors active against hospital acquired bacterial infections | Medical Research Fund of Warwick | 01 Jan 2006 | 30 Sept 2006 |
| Purchase of Electronic Noses via MRF | Eveson Charitable Trust | 21 Oct 2005 | 20 Sept 2006 |
| Undergraduate Vacation Bursary: Psuedomonas in Mushrooms; Pathogenicity Assessments. | British Society for Plant Pathology | 11 Jul 2006 | 04 Sept 2006 |
| Bridging Award for Dr Sehra | Royal Commission for the Exhibition of 1851 | 01 Jun 2005 | 31 May 2006 |
| Genetic Diversity and Gene Expression in Pseudomonas Aeruginosa - Barry Curran | Micropathology Limited | 01 Oct 2002 | 30 Sept 2005 |
| Developing a multilocus sequence typing scheme to characterise the causative agent of acne, Propionibacterium acnes | Society for General Microbiology | 27 Jun 2005 | 19 Aug 2005 |
| Contribution to BBSRC case award (Barry Curran)Genetic and Phenotypic Diversity of Pseudomonas Aeruginosa | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2003 | 31 Mar 2005 |
| The Characterisation and Activities of Compylobacter Jejuni and Listeria Monocylogenes Bacteriophage - CASE Award - James Taylor | Biotek Limited | 02 Oct 2000 | 30 Sept 2003 |