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How can computational methods create new diagnostics and treatment?

Can we use these methods help us to improve health across the lifespan?

Neuroscience at the University of Warwick focusses on a number of key areas.

These include the brain’s response to acute injury, the influence of experience on neuronal structure, function and cognition, and the homeostatic regulation of cardiovascular activity, respiration and appetitive behaviour.

These areas span both human health and disease, and encompass both early development and later life. Using electrophysiological and optical techniques, as well as amperometric biosensors and computational methods developed at Warwick, Warwick Neuroscience addresses the cellular and molecular underpinnings of complex neurobiological processes with a view to both appreciate the fundamentals of nervous system function, and to deliver novel diagnostics and therapeutics.

'Functional applications of stable Tau Oligomers in cell biology and electrophysiology studies.'

Emily Hill, Kevin G. Moffat, Mark J. Wall, Henrik Zetterberg, Kaj Blennow, and Thomas K. Karikari, (2023)
In: Protein Aggregation. Methods in Molecular Biology, 2551 . New York, NY: Humana, pp. 147-161.

'Analyzing the brainstem circuit for respiratory chemosensitivity in freely moving mice'
Amol M. Bhandare, Joseph van de Wiel, Reno Roberts, Inke Braren, Robert T. R. Huckstepp, Robert T. R. and Nicholas Dale, (2022)
eLife, 11 . e70671

'Selective activation of Goob by an adenosine A 1 receptor agonist elicits analgesia without cardiorespiratory depression'
Mark J. Wall, Emily Hill, Robert T. R. Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabinra Carvalho, Anna Suchankova, et al (2022)
Nature Communications, 13 (1). 4150

'An Improved Model of Moderate Sleep Apnoea for Investigating Its Effect as a Comorbidity on Neurodegenerative Disease'
Reno Roberts, Mark J. Wall, Ingke Braren, Karendeep Dhillon, Amy Evans, Jack Dunne, Simbarashe  Nyakupinda, and Robert T. R. Huckstepp. (2022)
Frontiers in Aging Neuroscience

'Mitogen and stress-activated protein kinase 1 negatively regulates hippocampal neurogenesis'
Oladiran Morè Olateju, Arthur J Lorenzo, C Simon and Bruno G Frenguelli, (2021)

'Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations'
Ján Lopatář, Nicholas Dale,and Bruno G.
Frenguelli, (2015)

'Purines : from diagnostic biomarkers to therapeutic agents in brain injury'
Bruno G. Frenguelli and Nicholas Dale, (2020)
Neuroscience bulletin

'Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network'
Matei Bolborea, Eric Pollatzek, Heather Benford, Tamara Sotelo-Hitschfeld and Nicholas Dale, (2020)
Proceedings of the National Academy of Sciences of the United States of America, 117 (25), pp. 14473-14481