Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90.
Dutton, B. L., Kitson, R.R.A., Parry-Morris, S., Roe, S.M., Prodromou, C., Moody, C.J., Org. Biomol.Chem., 2014, 12, 1328-1340.
19-Substituted benzoquinone ansamycin heat shock protein-90 inhibitors: Biological activity and decreased off-target toxicity. Chang, C.-H., Dreschel, D.A., Kitson, R.R.A., Siegel, D., You, Q., Backos, D.S., Ju, C., Moody, C.J., Ross, D., Mol. Pharm., 2014, 85, 849-857.
Heat shock protein 90 controls HIV-1 reactivation from latency. Anderson, I., Low, J.S., Weston, S., Weinberger, M., Zhyvouloup, A., Labokha, A.A., Corazza, G., Kitson, R.R.A., Moody, C.J., Marcello, A., Fassati, A., PNAS., 2014, 111, E1528-E1537.
Toward the Total Synthesis of Hygrocin B and Divergolide C: Construction of the Naphthoquinone–Azepinone Core. Nawrat, C.C., Kitson, R.R.A., Moody, C.J., Org. Lett., 2014, 16, 1896-1899.
An Improved Route to 19-Substituted Geldanamycins. Kitson, R.R.A., Moody, C.J., Chem. Commun., 2013, 49, 8441-8443.
Learning from Nature: Advances in Geldanamycin and Radicicol-Based Inhibitors of Hsp90.Kitson, R.R.A., Moody, C.J., J. Org. Chem., 2013, 78, 5117-5141.
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.Kitson, R.R.A., Chang, C.-H., Xiong, R., Dehn, D. L., Williams, H.E.L, Davis, A.L., Lewis, W., Siegel, D., Roe, S.M., Prodromou, C., Ross, D., Moody, C.J., Nature Chem. 2013, 9426-9451.
The Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches.Kitson, R.R.A., Millemaggi, A., Taylor, R.J.K., Angew. Chem. Int. Ed., 2009, 9426-9451.
A One-Pot, Base-Free Annelation Approach to α-Alkylidene-γ-butyrolactones.Kitson, R.R.A., Taylor, R.J.K., Wood, J.L., Org. Lett., 2009, 5338-5341.
The Telescoped Intramolecular Michael/Olefination (TIMO) Approach to α-Alkylidene-γ-butyrolactones: Synthesis of (+)-Paeonilactone B. Edwards, M.G., Kenworthy M.N., Kitson, R.R.A., Scott, M.S., Taylor, R.J.K. Angew. Chem. Int. Ed., 2008, 1935-1937.
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